Gene Information gene info

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GENE：MARCHF5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MARCHF5
FullNmae membrane associated ring-CH-type finger 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:26025
EnsembleID ENSG00000198060
Uniprot Q9NX47

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MARCHF5 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MARCHF5 GO:0000209,GO:0000209,GO:0005515,GO:0005739,GO:0005741,GO:0005741,GO:0005783,GO:0005789,GO:0008270,GO:0016020,GO:0051020,GO:0051865,GO:0061630,GO:0061630,GO:0061630,GO:0070585,GO:0090140,GO:0090140,GO:0090141

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MARCHF5 hsa:54708 path:hsa04137 Mitophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MARCHF5 MAVS 23180781 26246171 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR MARCHF5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MARCHF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MARCHF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MARCHF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MARCHF5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 MARCHF5 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000000B1C9 MARCHF5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EED18 MARCHF5 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS0000060B2B MARCHF5 22927820 23313552 23824327 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS000076B539 MARCHF5 22927820 23313552 23824327 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS0000085F64 MARCHF5 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
UBE2I MARCHF5 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRAF6 MARCHF5 25348397 N/A physical interaction ComPPI
UBE2D1 MARCHF5 25348397 N/A physical interaction ComPPI
BIK MARCHF5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FUNDC1 MARCHF5 25348397 N/A physical interaction ComPPI
FATE1 MARCHF5 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FIS1 MARCHF5 14525934 16874301 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TIMMDC1 MARCHF5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 MFN2 14525934 16936636 23727017 24234451 25348397 26186194 26210454 27898060 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
MARCHF5 UTRN 14525934 16936636 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MARCHF5 UBE2N 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MARCHF5 UBE2W 19549727 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MARCHF5 AKTIP 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MARCHF5 UBE2T 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MARCHF5 TANK 21625535 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MARCHF5 MAVS 25348397 N/A physical interaction ComPPI
MARCHF5 MFN1 20103533 23253261 24722297 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MARCHF5 SOD1 25348397 N/A physical interaction ComPPI
MARCHF5 MAP1B 25348397 N/A physical interaction ComPPI
MARCHF5 UBE2D2 25348397 N/A physical interaction ComPPI
MARCHF5 UBE2D3 25348397 N/A physical interaction ComPPI
MARCHF5 CCNB1 25348397 N/A physical interaction ComPPI
MARCHF5 DNM1L 25348397 N/A physical interaction ComPPI
MARCHF5 PRKN 25348397 N/A physical interaction ComPPI
MARCHF5 UBE2E1 25348397 N/A physical interaction ComPPI
MARCHF5 MIA3 25348397 N/A physical interaction ComPPI
MARCHF5 GRAMD2B 25348397 N/A physical interaction ComPPI
MARCHF5 UNK 25348397 N/A physical interaction ComPPI
MARCHF5 CREB3 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MARCHF5 SLC25A38 25348397 N/A physical interaction ComPPI
MARCHF5 SLC25A26 25348397 N/A physical interaction ComPPI
MARCHF5 LAMP3 25348397 N/A physical interaction ComPPI
MARCHF5 ATXN3 25348397 N/A physical interaction ComPPI
MARCHF5 UBC 16874301 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
MARCHF5 DENR 16874301 16936636 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
MARCHF5 SAR1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 MANBAL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 BNIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 TMEM139 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 PTPN5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 GPX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 ODF4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 AQP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 YIF1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 SCD 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MARCHF5 RTN4IP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2E3 MARCHF5 25348397 N/A physical interaction ComPPI
ECPAS MARCHF5 25348397 N/A physical interaction ComPPI
MARCHF5 MARCHF5 14525934 16874301 N/A experimental interaction detection HPRD
MARCHF5 DDX58 19484123 27898060 stimulant N/A OmniPath

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