Gene Information gene info

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GENE：MARS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MARS2
FullNmae methionyl-tRNA synthetase 2, mitochondrial
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25133
EnsembleID ENSG00000247626
Uniprot Q96GW9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MARS2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MARS2 GO:0004825,GO:0004825,GO:0004825,GO:0005524,GO:0005759,GO:0005759,GO:0006418,GO:0006431,GO:0006431

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MARS2 hsa:92935 path:hsa00450 Selenocompound metabolism - Homo sapiens (human)
MARS2 hsa:92935 path:hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)
MARS2 hsa:92935 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 MARS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 MARS2 N/A rna interference,inhibition experimental interaction detection miRSponge
URS0000324096 MARS2 18668040 25416803 26701625 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS00001C770D MARS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000017CCCB MARS2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 MARS2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A07C1 MARS2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000000B1C9 MARS2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000029979D MARS2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000237CBD MARS2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000052E1A6 MARS2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000032EF64 MARS2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001067D1 MARS2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000122ED0 MARS2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MARS2 AIMP1 25361965 interaction type N/A PTMCode2
AIMP1 MARS2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SMURF2 MARS2 25348397 N/A physical interaction ComPPI
FCGR2B MARS2 25348397 N/A physical interaction ComPPI
SLC9A3R2 MARS2 25348397 N/A physical interaction ComPPI
ALDOC MARS2 25348397 N/A physical interaction ComPPI
NDUFS7 MARS2 25348397 N/A physical interaction ComPPI
HSPD1 MARS2 25348397 N/A physical interaction ComPPI
MRPL4 MARS2 25348397 N/A physical interaction ComPPI
FAM219A MARS2 25348397 N/A physical interaction ComPPI
APP MARS2 25348397 N/A physical interaction ComPPI
GCDH MARS2 25348397 N/A physical interaction ComPPI
YBEY MARS2 25348397 N/A physical interaction ComPPI
MARS2 HROB 25348397 N/A physical interaction ComPPI
HSCB MARS2 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct

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