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GENE：MBTPS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MBTPS1
FullNmae membrane bound transcription factor peptidase, site 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:15456
EnsembleID ENSG00000140943
Uniprot Q14703

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MBTPS1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MBTPS1 GO:0000139,GO:0000139,GO:0000139,GO:0004252,GO:0004252,GO:0004252,GO:0004252,GO:0005515,GO:0005788,GO:0005789,GO:0005794,GO:0005795,GO:0006508,GO:0007040,GO:0007095,GO:0008203,GO:0016485,GO:0030968,GO:0031293,GO:0034976,GO:0036500,GO:0045540,GO:0051604,GO:0051604,GO:0060627

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MBTPS1 hsa:8720 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 MBTPS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MBTPS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MBTPS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C MBTPS1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MBTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MBTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MBTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MBTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MBTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MBTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MBTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MBTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 MBTPS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A MBTPS1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004E008F MBTPS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 MBTPS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 MBTPS1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PEX19 MBTPS1 25348397 N/A physical interaction ComPPI
CANX MBTPS1 11756446 14525934 24234451 25348397 27898060 29568061 association experimental interaction detection,pull down,in vivo ComPPI,HPRD,IntAct,OmniPath
PLAUR MBTPS1 25348397 N/A physical interaction ComPPI
HNRNPL MBTPS1 25348397 N/A physical interaction ComPPI
TNFSF11 MBTPS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HDAC2 MBTPS1 25348397 N/A physical interaction ComPPI
TAZ MBTPS1 25348397 N/A physical interaction ComPPI
BIRC3 MBTPS1 25348397 N/A physical interaction ComPPI
MBTPS1 BDNF 14525934 25348397 9990022 N/A experimental interaction detection,in vitro ComPPI,HPRD
MBTPS1 HDAC1 25348397 N/A physical interaction ComPPI
MBTPS1 TNFRSF14 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MBTPS1 SPHK1 25348397 N/A physical interaction ComPPI
MBTPS1 MOV10 25348397 N/A physical interaction ComPPI
MBTPS1 NXF1 25348397 N/A physical interaction ComPPI
TANK MBTPS1 24234451 30561431 association virotrap IntAct
MBTPS1 BDNF 11152678 27898060 9990022 N/A N/A OmniPath
MBTPS1 CREB3L1 16417584 27898060 stimulant N/A OmniPath
MBTPS1 CREB3L2 17178827 27898060 stimulant N/A OmniPath

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