Gene Information gene info

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GENE：MCUR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MCUR1
FullNmae mitochondrial calcium uniporter regulator 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21097
EnsembleID ENSG00000050393
Uniprot Q96AQ8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MCUR1 mpt 33041854 The mitochondrial calcium uniporter complex through which calcium enters the mitochondria is composed of several proteins, including the pore-forming subunit MCU and its regulators MCUR1, MICU1, and MICU2. Mitochondrial calcium overload leads to opening of MPTP (mitochondrial permeability transition pore) and results in apoptotic cell death. retulator signature
MCUR1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MCUR1 GO:0005515,GO:0005739,GO:0005743,GO:0006851,GO:0036444,GO:0036444,GO:0051561,GO:0051561,GO:0070509

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 MCUR1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MCUR1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MCUR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MCUR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MCUR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MCUR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MCUR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MCUR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MCUR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MCUR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MCUR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MCUR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MCUR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MCUR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 MCUR1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00005651EE MCUR1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002971AB MCUR1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 MCUR1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 MCUR1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C MCUR1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 MCUR1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 MCUR1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 MCUR1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE MCUR1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000032FC1A MCUR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D MCUR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 MCUR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C MCUR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 MCUR1 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 MCUR1 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 MCUR1 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 MCUR1 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 MCUR1 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 MCUR1 23706177 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FAF2 MCUR1 25348397 N/A physical interaction ComPPI

Visualization










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