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GENE：MDH2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MDH2
FullNmae malate dehydrogenase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6971
EnsembleID ENSG00000146701
Uniprot P40926

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MDH2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MDH2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MDH2 GO:0003723,GO:0005634,GO:0005737,GO:0005739,GO:0005739,GO:0005739,GO:0005759,GO:0006094,GO:0006099,GO:0006099,GO:0006107,GO:0006108,GO:0006108,GO:0006734,GO:0009060,GO:0016020,GO:0030060,GO:0030060,GO:0030060,GO:0030060,GO:0043621,GO:0046554,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MDH2 hsa:4191 path:hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
MDH2 hsa:4191 path:hsa00270 Cysteine and methionine metabolism - Homo sapiens (human)
MDH2 hsa:4191 path:hsa00620 Pyruvate metabolism - Homo sapiens (human)
MDH2 hsa:4191 path:hsa00630 Glyoxylate and dicarboxylate metabolism - Homo sapiens (human)
MDH2 hsa:4191 path:hsa01100 Metabolic pathways - Homo sapiens (human)
MDH2 hsa:4191 path:hsa01200 Carbon metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDK2 MDH2 21319273 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 MDH2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C MDH2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA MDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000183BED MDH2 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000FC8EB MDH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 MDH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 MDH2 23622248 25416803 27292025 mrna cleavage,inhibition clip,clash TarBase
URS00005651EE MDH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000048BA36 MDH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD MDH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000330617 MDH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 MDH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000367985 MDH2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000016914 MDH2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000306C70 MDH2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075BEA7 MDH2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 MDH2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004B4B85 MDH2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 MDH2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000049FAE8 MDH2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CYC1 MDH2 25361965 interaction type N/A PTMCode2
MDH2 CYC1 25361965 interaction type N/A PTMCode2
NDUFAB1 MDH2 25361965 interaction type N/A PTMCode2
MDH2 NDUFAB1 25361965 interaction type N/A PTMCode2
MDH2 HSPD1 25361965 interaction type N/A PTMCode2
HSPD1 MDH2 25361965 interaction type N/A PTMCode2
MDH2 CS 25361965 interaction type N/A PTMCode2
CS MDH2 25361965 interaction type N/A PTMCode2
MDH2 FH 25361965 interaction type N/A PTMCode2
FH MDH2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CRYAB MDH2 25348397 N/A physical interaction ComPPI
ATP5F1B MDH2 25348397 N/A physical interaction ComPPI
PCNA MDH2 20849852 24234451 25348397 physical association far western blotting,physical interaction ComPPI,IntAct
CFL1 MDH2 25348397 N/A physical interaction ComPPI
CLNS1A MDH2 25348397 N/A physical interaction ComPPI
GABARAPL2 MDH2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
COTL1 MDH2 25348397 N/A physical interaction ComPPI
KEAP1 MDH2 25348397 N/A physical interaction ComPPI
RAB10 MDH2 25348397 N/A physical interaction ComPPI
NFATC1 MDH2 25348397 N/A physical interaction ComPPI
JUN MDH2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 MDH2 25348397 N/A physical interaction ComPPI
UBE2L3 MDH2 25348397 N/A physical interaction ComPPI
PSMA3 MDH2 25348397 N/A physical interaction ComPPI
U2AF2 MDH2 25348397 N/A physical interaction ComPPI
SERPINH1 MDH2 25348397 N/A physical interaction ComPPI
NTRK1 MDH2 25348397 N/A physical interaction ComPPI
PPP1CA MDH2 24234451 25348397 25593058 association anti bait coimmunoprecipitation ComPPI,IntAct
MAPK13 MDH2 19135240 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CFTR MDH2 25348397 N/A physical interaction ComPPI
PDHA1 MDH2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HUWE1 MDH2 25348397 N/A physical interaction ComPPI
CDK2 MDH2 25348397 N/A physical interaction ComPPI
GABARAP MDH2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MAP1LC3A MDH2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
VCAM1 MDH2 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 MDH2 25348397 N/A physical interaction ComPPI
DNM1L MDH2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
IDH3A MDH2 25348397 N/A physical interaction ComPPI
PRKN MDH2 25348397 N/A physical interaction ComPPI
CUL7 MDH2 25348397 N/A physical interaction ComPPI
HDAC5 MDH2 25348397 N/A physical interaction ComPPI
PSMD4 MDH2 25348397 N/A physical interaction ComPPI
TRIM25 MDH2 25348397 N/A physical interaction ComPPI
DERL1 MDH2 25348397 N/A physical interaction ComPPI
GLRX2 MDH2 25348397 N/A physical interaction ComPPI
BRCA1 MDH2 25348397 N/A physical interaction ComPPI
NUDC MDH2 25348397 N/A physical interaction ComPPI
PARK7 MDH2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SOD1 MDH2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATF2 MDH2 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAZAP1 MDH2 25348397 N/A physical interaction ComPPI
YKT6 MDH2 25348397 N/A physical interaction ComPPI
HSPD1 MDH2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DLST MDH2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
WARS1 MDH2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FUS MDH2 25348397 N/A physical interaction ComPPI
PC MDH2 14525934 25348397 8349677 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GOT2 MDH2 14525934 25348397 27898060 2899080 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
HSD17B10 MDH2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATP5F1A MDH2 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
MDH2 CS 14525934 25348397 27898060 7285903 9792662 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
MDH2 FH 14525934 25348397 2759092 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
MDH2 NDUFS1 14525934 25348397 27898060 6439716 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
MDH2 LDHAL6A 25348397 N/A physical interaction ComPPI
MDH2 IDH1 25348397 N/A physical interaction ComPPI
MDH2 MRPS28 25348397 N/A physical interaction ComPPI
MDH2 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
MDH2 EEF1AKMT3 25348397 N/A physical interaction ComPPI
MDH2 GRSF1 25348397 N/A physical interaction ComPPI
MDH2 OBSL1 25348397 N/A physical interaction ComPPI
MDH2 CCDC8 25348397 N/A physical interaction ComPPI
MDH2 CORO1C 25348397 N/A physical interaction ComPPI
MDH2 GRPEL1 25348397 N/A physical interaction ComPPI
MDH2 SDHA 25348397 N/A physical interaction ComPPI
MDH2 QSOX2 25348397 N/A physical interaction ComPPI
MDH2 SDHB 25348397 N/A physical interaction ComPPI
MDH2 UFM1 25348397 N/A physical interaction ComPPI
MDH2 PPME1 25348397 N/A physical interaction ComPPI
MDH2 CYLD 25348397 N/A physical interaction ComPPI
MDH2 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MDH2 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MDH2 PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
MDH2 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
MDH2 COQ2 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
MDH2 MDH2 14525934 9792106 N/A experimental interaction detection HPRD
TANK MDH2 24234451 30561431 association virotrap IntAct
H2BC9 MDH2 24234451 30021884 physical association cross-linking study IntAct
MDH2 G2E3 24234451 30021884 physical association cross-linking study IntAct

Visualization










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