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GENE：MECR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MECR
FullNmae mitochondrial trans-2-enoyl-CoA reductase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:19691
EnsembleID ENSG00000116353
Uniprot Q9BV79

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MECR immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MECR cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MECR GO:0005634,GO:0005739,GO:0005739,GO:0005759,GO:0006631,GO:0006631,GO:0006631,GO:0006633,GO:0019166,GO:0019166

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MECR hsa:51102 path:hsa00061 Fatty acid biosynthesis - Homo sapiens (human)
MECR hsa:51102 path:hsa00062 Fatty acid elongation - Homo sapiens (human)
MECR hsa:51102 path:hsa01100 Metabolic pathways - Homo sapiens (human)
MECR hsa:51102 path:hsa01212 Fatty acid metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR MECR 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MECR 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MECR 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MECR 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MECR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MECR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MECR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MECR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MECR 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 MECR 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00002F8148 MECR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC MECR 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
RARA MECR 25348397 N/A physical interaction ComPPI
THRB MECR 25348397 N/A two hybrid ComPPI
PPARA MECR 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
MECR HNF4A 25348397 N/A two hybrid ComPPI
MECR MOV10 25348397 N/A physical interaction ComPPI
MECR ATP6AP2 25348397 N/A physical interaction ComPPI
MECR RAB7A 25348397 N/A physical interaction ComPPI
MECR AURKA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct

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