GENE：MRPL14
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MRPL14 |
| FullNmae | mitochondrial ribosomal protein L14 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:14279 |
| EnsembleID | ENSG00000180992 |
| Uniprot | Q6P1L8 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MRPL14 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MRPL14 | GO:0003723,GO:0003735,GO:0005739,GO:0005739,GO:0005743,GO:0005743,GO:0005762,GO:0005762,GO:0032543 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MRPL14 | hsa:64928 | path:hsa03010 | Ribosome - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MRPL14 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | MRPL14 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | MRPL14 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | MRPL14 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | MRPL14 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| HIF1A | MRPL14 | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOXA1 | MRPL14 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MRPL14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MRPL14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MRPL14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MRPL14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MRPL14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MRPL14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | MRPL14 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RPS15 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL28 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| TUFM | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| ETS2 | MRPL14 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CUL3 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| DUT | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| MYC | MRPL14 | 21150319 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| EEF1A1 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| PDHA1 | MRPL14 | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| TNIK | MRPL14 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| VHL | MRPL14 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PDK1 | MRPL14 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| HNRNPR | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| RPS20 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| IKBKE | MRPL14 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PPIF | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| GADD45GIP1 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| SARNP | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| HSPD1 | MRPL14 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| MCC | MRPL14 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| RPS15A | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL4 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| NDUFA7 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| SRPRB | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL19 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPDL | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL10 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| TRMT61B | MRPL14 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| MRPL13 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| ZNF746 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL1 | MRPL14 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MRPL14 | MRPL2 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL14 | MRPL16 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL14 | CDV3 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL14 | ZC3H3 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL14 | MRPS30 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL14 | GOLT1B | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MRPL14 | WRAP53 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MRPL14 | NDUFA4 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL15 | MRPL14 | 25348397 | N/A | physical interaction | ComPPI |