GENE：MRPL17
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MRPL17 |
| FullNmae | mitochondrial ribosomal protein L17 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:14053 |
| EnsembleID | ENSG00000158042 |
| Uniprot | Q9NRX2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MRPL17 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MRPL17 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MRPL17 | GO:0003735,GO:0005515,GO:0005739,GO:0005743,GO:0005743,GO:0005762,GO:0005762,GO:0005762,GO:0019904,GO:0032543 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MRPL17 | hsa:63875 | path:hsa03010 | Ribosome - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | MRPL17 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | MRPL17 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | MRPL17 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | MRPL17 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MRPL17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MRPL17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MRPL17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | MRPL17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MRPL17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00002FC5B0 | MRPL17 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00004CD810 | MRPL17 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E1509 | MRPL17 | 22100165 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000008A99 | MRPL17 | 20371350 21572407 23446348 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000101787 | MRPL17 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000259AE4 | MRPL17 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000022AAA | MRPL17 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006FDD4 | MRPL17 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | MRPL17 | 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FF522 | MRPL17 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000137EDE | MRPL17 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000019907A | MRPL17 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000195F5B | MRPL17 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000939AF | MRPL17 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000042619A | MRPL17 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000EF0B | MRPL17 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003380CC | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CC20C | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C4B1 | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000753AD | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000038446A | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000013ABA3 | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E2232 | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031B6ED | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018D2BE | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EE7F0 | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000030F801 | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000011DF | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000001A7A | MRPL17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RPL8 | MRPL17 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL17 | RPL8 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL17 | MRPL11 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL11 | MRPL17 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL17 | RPL11 | 25361965 | interaction type | N/A | PTMCode2 |
| RPL11 | MRPL17 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL17 | RPL23 | 25361965 | interaction type | N/A | PTMCode2 |
| RPL23 | MRPL17 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL17 | GFM1 | 25361965 | interaction type | N/A | PTMCode2 |
| GFM1 | MRPL17 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL4 | MRPL17 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL17 | MRPL4 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPS7 | MRPL17 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL17 | MRPS7 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL15 | MRPL17 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL17 | MRPL15 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL27 | MRPL17 | 25361965 | interaction type | N/A | PTMCode2 |
| MRPL17 | MRPL27 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAD2L2 | MRPL17 | 24234451 25348397 29656893 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| MRPL28 | MRPL17 | 25348397 | N/A | physical interaction | ComPPI |
| TUFM | MRPL17 | 25348397 | N/A | physical interaction | ComPPI |
| BAG6 | MRPL17 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MAPK6 | MRPL17 | 24234451 25348397 29426014 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| NFATC2 | MRPL17 | 25348397 | N/A | physical interaction | ComPPI |
| PHB2 | MRPL17 | 25348397 | N/A | physical interaction | ComPPI |
| LYST | MRPL17 | 11984006 14525934 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| HNRNPF | MRPL17 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ILF2 | MRPL17 | 25348397 | N/A | physical interaction | ComPPI |
| RPL13 | MRPL17 | 25348397 | N/A | physical interaction | ComPPI |
| AURKAIP1 | MRPL17 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| POLR3A | MRPL17 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MRPL58 | 20186120 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MRPL17 | MRPL13 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MRPL3 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MPV17 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | DDX28 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | SLC25A3 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | ILF3 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | ZC3H3 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | RPS8 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MRPL39 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MRPS30 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MRPL47 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MRPL18 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MRPL2 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MRPL22 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MRPL37 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | POLR3B | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | RPS23 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | HCCS | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MRPL17 | MRPL50 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MRPL17 | UBA5 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MRPL17 | POU5F1 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MRPL10 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | RSPRY1 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MRPL42 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | SLC25A10 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | ZNF324B | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | MRPL41 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | RPL18 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | CYLD | 25348397 | N/A | physical interaction | ComPPI |
| MRPL4 | MRPL17 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL12 | MRPL17 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL9 | MRPL17 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| UBTD2 | MRPL17 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MRPL1 | MRPL17 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MKI67 | MRPL17 | 24234451 26949251 | association | anti tag coimmunoprecipitation | IntAct |