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GENE：MRPL21

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MRPL21
FullNmae mitochondrial ribosomal protein L21
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14479
EnsembleID ENSG00000197345
Uniprot Q7Z2W9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MRPL21 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MRPL21 GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005743,GO:0005762,GO:0005762,GO:0005762,GO:0032543

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MRPL21 hsa:219927 path:hsa03010 Ribosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 MRPL21 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MRPL21 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MRPL21 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C MRPL21 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MRPL21 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MRPL21 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MRPL21 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MRPL21 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003D5391 MRPL21 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
CUL3 MRPL21 25348397 N/A physical interaction ComPPI
BTRC MRPL21 25348397 N/A physical interaction ComPPI
C1QBP MRPL21 25348397 N/A physical interaction ComPPI
RPS6 MRPL21 24234451 25348397 29568061 association pull down ComPPI,IntAct
CASQ2 MRPL21 25348397 N/A physical interaction ComPPI
PDK1 MRPL21 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ILF2 MRPL21 25348397 N/A physical interaction ComPPI
TOP3A MRPL21 25348397 N/A physical interaction ComPPI
ELAC2 MRPL21 25348397 N/A physical interaction ComPPI
FOXL2 MRPL21 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
AURKAIP1 MRPL21 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FAF2 MRPL21 25348397 N/A physical interaction ComPPI
HSPD1 MRPL21 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HNRNPA1 MRPL21 25348397 N/A physical interaction ComPPI
CYLD MRPL21 25348397 N/A physical interaction ComPPI
MRPL20 MRPL21 25348397 N/A physical interaction ComPPI
MRPL4 MRPL21 25348397 N/A physical interaction ComPPI
MRPL19 MRPL21 25348397 N/A physical interaction ComPPI
MRPL10 MRPL21 25348397 N/A physical interaction ComPPI
TRMT61B MRPL21 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RPS8 MRPL21 25348397 N/A physical interaction ComPPI
MRPL1 MRPL21 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MRPL24 MRPL21 25348397 N/A physical interaction ComPPI
MRPS30 MRPL21 25348397 N/A physical interaction ComPPI
IARS2 MRPL21 25348397 N/A physical interaction ComPPI
MRPL21 ZC3H3 25348397 N/A physical interaction ComPPI

Source Target Pmid Interactiontype Methods Database
URS00009C442D MRPL21 27087310 direct interaction,inhibition N/A NPInter

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