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GENE：MRPL2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MRPL2
FullNmae mitochondrial ribosomal protein L2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14056
EnsembleID ENSG00000112651
Uniprot Q5T653

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MRPL2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MRPL2 GO:0003723,GO:0003723,GO:0003735,GO:0005654,GO:0005739,GO:0005743,GO:0005743,GO:0005762,GO:0005762,GO:0005762,GO:0032543,GO:0032543

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MRPL2 hsa:51069 path:hsa03010 Ribosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 MRPL2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HNF4A MRPL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MRPL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000008F0CF MRPL2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
RPL11 MRPL2 25361965 interaction type N/A PTMCode2
MRPL2 RPL11 25361965 interaction type N/A PTMCode2
MRPL4 MRPL2 25361965 interaction type N/A PTMCode2
MRPL2 MRPL4 25361965 interaction type N/A PTMCode2
MRPS7 MRPL2 25361965 interaction type N/A PTMCode2
MRPL2 MRPS7 25361965 interaction type N/A PTMCode2
TUFM MRPL2 25361965 interaction type N/A PTMCode2
MRPL2 TUFM 25361965 interaction type N/A PTMCode2
MRPL2 RPL23 25361965 interaction type N/A PTMCode2
RPL23 MRPL2 25361965 interaction type N/A PTMCode2
MRPL2 GFM1 25361965 interaction type N/A PTMCode2
GFM1 MRPL2 25361965 interaction type N/A PTMCode2
MRPL15 MRPL2 25361965 interaction type N/A PTMCode2
MRPL2 MRPL15 25361965 interaction type N/A PTMCode2
MRPL11 MRPL2 25361965 interaction type N/A PTMCode2
MRPL2 MRPL11 25361965 interaction type N/A PTMCode2
MRPL27 MRPL2 25361965 interaction type N/A PTMCode2
MRPL2 MRPL27 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RPS15 MRPL2 25348397 N/A physical interaction ComPPI
MRPL28 MRPL2 25348397 N/A physical interaction ComPPI
MRPL40 MRPL2 25348397 N/A physical interaction ComPPI
TUFM MRPL2 25348397 N/A physical interaction ComPPI
MRPL23 MRPL2 25348397 N/A physical interaction ComPPI
SMURF2 MRPL2 18157088 24234451 25348397 physical association two hybrid ComPPI,IntAct
EZH2 MRPL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN MRPL2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
CUL3 MRPL2 25348397 N/A physical interaction ComPPI
YBX1 MRPL2 22118625 24234451 25348397 association tandem affinity purification ComPPI,IntAct
EIF3C MRPL2 25348397 N/A physical interaction ComPPI
PDHA1 MRPL2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPS18 MRPL2 25348397 N/A physical interaction ComPPI
PHB2 MRPL2 25348397 N/A physical interaction ComPPI
TRIM63 MRPL2 18157088 24234451 25348397 physical association two hybrid ComPPI,IntAct
FUBP1 MRPL2 25348397 N/A physical interaction ComPPI
POLR3A MRPL2 25348397 N/A physical interaction ComPPI
MRPL17 MRPL2 25348397 N/A physical interaction ComPPI
DLST MRPL2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CYLD MRPL2 25348397 N/A physical interaction ComPPI
MRPL42 MRPL2 25348397 N/A physical interaction ComPPI
MRPL4 MRPL2 25348397 N/A physical interaction ComPPI
GTPBP4 MRPL2 25348397 N/A physical interaction ComPPI
SLC25A3 MRPL2 25348397 N/A physical interaction ComPPI
TUBA1C MRPL2 25348397 N/A physical interaction ComPPI
MGST3 MRPL2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL9 MRPL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MTRES1 MRPL2 25348397 N/A physical interaction ComPPI
TSR1 MRPL2 25348397 N/A physical interaction ComPPI
MRPS7 MRPL2 25348397 N/A physical interaction ComPPI
MRPL10 MRPL2 25348397 N/A physical interaction ComPPI
MRPL39 MRPL2 25348397 N/A physical interaction ComPPI
MRPL37 MRPL2 25348397 N/A physical interaction ComPPI
TRMT61B MRPL2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL13 MRPL2 25348397 N/A physical interaction ComPPI
RPS8 MRPL2 25348397 N/A physical interaction ComPPI
MRPL58 MRPL2 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DDX28 MRPL2 25348397 N/A physical interaction ComPPI
GRSF1 MRPL2 25348397 N/A physical interaction ComPPI
MRPL1 MRPL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MRPL11 MRPL2 25348397 N/A physical interaction ComPPI
MRPL14 MRPL2 25348397 N/A physical interaction ComPPI
MRPL16 MRPL2 25348397 N/A physical interaction ComPPI
MRPL18 MRPL2 25348397 N/A physical interaction ComPPI
MRPL2 MRPL24 25348397 N/A physical interaction ComPPI
MRPL2 CMTM4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MRPL2 MRPS30 25348397 N/A physical interaction ComPPI
MRPL2 MRPL47 25348397 N/A physical interaction ComPPI
MRPL2 GFM2 25348397 N/A physical interaction ComPPI
MRPL2 MRPL22 25348397 N/A physical interaction ComPPI
MRPL2 MRPL32 25348397 N/A physical interaction ComPPI
MRPL2 MRPL50 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MRPL2 MASTL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MRPL2 MRPL35 25348397 N/A physical interaction ComPPI

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