Gene Information gene info

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GENE：PKN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PKN1
FullNmae protein kinase N1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9405
EnsembleID ENSG00000123143
Uniprot Q16512

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PKN1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PKN1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PKN1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PKN1 GO:0001782,GO:0001783,GO:0001933,GO:0002634,GO:0002637,GO:0003014,GO:0003682,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004697,GO:0004697,GO:0004698,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0006338,GO:0006357,GO:0006357,GO:0006468,GO:0006972,GO:0007165,GO:0010631,GO:0018105,GO:0030374,GO:0030374,GO:0030496,GO:0030889,GO:0031267,GO:0032154,GO:0032991,GO:0035402,GO:0035556,GO:0042393,GO:0042826,GO:0043687,GO:0045893,GO:0048536,GO:0050681,GO:0060765,GO:0106310,GO:2000145

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PKN1 hsa:5585 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PKN1 hsa:5585 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
PKN1 hsa:5585 path:hsa05132 Salmonella infection - Homo sapiens (human)
PKN1 hsa:5585 path:hsa05135 Yersinia infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PKN1 TRAF2 14741690 23180781 physical association anti tag coimmunoprecipitation,two hybrid,gst pull down InnateDB
PKN1 PKN1 14741690 23180781 phosphorylation reaction in-gel kinase assay InnateDB
PDPK1 PKN1 10764742 23180781 physical association two hybrid,pull down InnateDB
PKN1 TNFRSF1B 18429822 23180781 physical association anti tag coimmunoprecipitation InnateDB
PKN1 CCDC85B 16189514 23180781 physical association pull down InnateDB
PKN1 FZD7 24114839 phosphorylation reaction,stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AKAP9 PKN1 20005715 interaction type N/A PSP
TRAF2 PKN1 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ETS1 PKN1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PKN1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PKN1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PKN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PKN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PKN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PKN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PKN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PKN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HLX PKN1 22897850 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 PKN1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000048BA36 PKN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000812128 PKN1 24297251 direct interaction,inhibition high throughput sequencing StarBase

Source Target Pmid Interactiontype Methods Database
PKN1 EGFR 22135298 phosphorylation N/A PhosphoSite
PKN1 HDAC9 22135298 phosphorylation N/A PhosphoSite
PKN1 HDAC5 22135298 phosphorylation N/A PhosphoSite
PKN1 H3C1 22135298 phosphorylation N/A PhosphoSite
PKN1 MEFV 22135298 phosphorylation N/A PhosphoSite
PKN1 CLIP1 22135298 phosphorylation N/A PhosphoSite
PKN1 PKN1 22135298 phosphorylation N/A PhosphoSite
PDPK1 PKN1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RAC2 PKN1 25361965 interaction type N/A PTMCode2
PKN1 RAC2 25361965 interaction type N/A PTMCode2
PKN1 PDPK1 25361965 interaction type N/A PTMCode2
PKN1 MAP2K3 25361965 interaction type N/A PTMCode2
MAP2K3 PKN1 25361965 interaction type N/A PTMCode2
PKN1 MARCKS 25361965 interaction type N/A PTMCode2
MARCKS PKN1 25361965 interaction type N/A PTMCode2
PKN1 MAP3K20 25361965 interaction type N/A PTMCode2
MAP3K20 PKN1 25361965 interaction type N/A PTMCode2
VIM PKN1 25361965 interaction type N/A PTMCode2
PKN1 VIM 25361965 interaction type N/A PTMCode2
CASP3 PKN1 25361965 interaction type N/A PTMCode2
PKN1 CASP3 25361965 interaction type N/A PTMCode2
ARHGAP10 PKN1 25361965 interaction type N/A PTMCode2
PKN1 ARHGAP10 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 PKN1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MAPK9 PKN1 25348397 N/A physical interaction ComPPI
KRT19 PKN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX11 PKN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT38 PKN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VIM PKN1 14525934 24234451 25348397 25416956 9175763 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
TUBB PKN1 25348397 N/A physical interaction ComPPI
CDR2 PKN1 14525934 24234451 25348397 25416956 9637778 physical association experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
MKRN3 PKN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRT31 PKN1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CCDC85B PKN1 14525934 16189514 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid pooling approach,two hybrid ComPPI,HPRD,IntAct
HSP90AB1 PKN1 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
PNMA1 PKN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPAG5 PKN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SERTAD3 PKN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD44 PKN1 14525934 15123640 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PICK1 PKN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CD81 PKN1 25348397 N/A physical interaction ComPPI
CASP3 PKN1 14525934 25348397 9751706 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK14 PKN1 12761180 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
RHOA PKN1 10619026 14525934 24234451 25348397 8571127 9446575 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PKN1 MAP2K6 12761180 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PKN1 MAPK12 12761180 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PKN1 ACTN1 11802708 14525934 25348397 9030526 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PKN1 NEUROD2 10640683 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PKN1 PDPK1 10753910 10764742 10792047 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PKN1 ARHGAP26 11432776 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PKN1 MARCKS 11930178 14525934 25348397 8557118 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PKN1 ARHGAP10 11432776 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PKN1 ZFAND6 11054541 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PKN1 CDC25C 14525934 15791647 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PKN1 TRAF2 14525934 14741690 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
PKN1 CCNT2 14525934 16331689 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PKN1 MAPT 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PKN1 NEFH 14525934 25348397 8621664 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PKN1 PLD1 11259428 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PKN1 PDK1 25348397 N/A physical interaction ComPPI
PKN1 AKAP9 25348397 N/A physical interaction ComPPI
PKN1 HDAC5 25348397 N/A physical interaction ComPPI
PKN1 HDAC6 19036992 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PKN1 H3C15 25348397 N/A physical interaction ComPPI
PKN1 ZNF282 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PKN1 SPRR2D 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PKN1 TUBA1A 25348397 N/A physical interaction ComPPI
PKN1 TOM1L1 25348397 N/A physical interaction ComPPI
PKN1 TRAF1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 TNFRSF1B 25348397 N/A physical interaction ComPPI
PKN1 MAPK11 25348397 N/A physical interaction ComPPI
PKN1 MAP2K3 12761180 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PKN1 HSP90AA1 25348397 N/A physical interaction ComPPI
PKN1 HSP90AA2P 25348397 N/A physical interaction ComPPI
PKN1 MBP 25348397 N/A physical interaction ComPPI
PKN1 BUD23 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PKN1 TBXA2R 25348397 N/A physical interaction ComPPI
PKN1 H1-1 25348397 N/A physical interaction ComPPI
PKN1 PA2G4 25348397 N/A physical interaction ComPPI
PKN1 KRT15 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PKN1 MID1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PKN1 HOMER3 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PKN1 SSX2IP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PKN1 CEP57L1 25348397 N/A physical interaction ComPPI
PKN1 KMT2A 25348397 N/A physical interaction ComPPI
PKN1 RBBP5 25348397 N/A physical interaction ComPPI
PKN1 ASH2L 25348397 N/A physical interaction ComPPI
PKN1 MAGEA10 25348397 N/A physical interaction ComPPI
PKN1 PLAUR 25348397 N/A physical interaction ComPPI
PKN1 RHEX 25348397 N/A physical interaction ComPPI
PKN1 PPM1A 25348397 N/A physical interaction ComPPI
PKN1 PPM1G 25348397 N/A physical interaction ComPPI
PKN1 NTRK1 25348397 N/A physical interaction ComPPI
PKN1 KBTBD8 25348397 N/A physical interaction ComPPI
PKN1 COG6 25348397 N/A physical interaction ComPPI
PKN1 AEN 25348397 N/A physical interaction ComPPI
PKN1 FUOM 25348397 N/A physical interaction ComPPI
PKN1 HNRNPL 25348397 N/A physical interaction ComPPI
PKN1 PRKCB 25348397 N/A pull down,pull down,physical interaction ComPPI
PKN1 KDM1A 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
PKN1 AKT1 23223530 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PKN1 MAP3K20 25348397 N/A anti tag coimmunoprecipitation ComPPI
PKN1 INTS11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 HAUS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 ARSA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 LRRC61 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 USHBP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 MIPOL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 BLZF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 SMYD3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 CCDC103 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 KRT34 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 CYSRT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 CEP70 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 TSGA10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 DYDC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 TRIM27 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 KIAA1328 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 KRT16 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 KRT37 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 KRT35 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 ZRANB1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 POU6F2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 HAP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 HSF2BP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 EIF3F 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 GOLGA6L9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 PKN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
WDR5 PKN1 25348397 N/A physical interaction ComPPI
NEFL PKN1 14525934 25348397 8621664 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SYCE3 PKN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKN1 PKN1 10467162 10792047 14525934 N/A experimental interaction detection HPRD
KRT10 PKN1 15860008 25194029 27898060 N/A N/A OmniPath
PKN1 NLRP2 11739778 15711538 17898076 18939955 27898060 9885245 N/A N/A OmniPath
PKN1 SLA2 20159853 27898060 N/A N/A OmniPath
PKN1 MARCKS 11930178 17287340 17322306 18212344 18578522 18669648 18707149 18767875 19413330 19651622 19664995 20058876 20068231 20166139 27898060 8557118 stimulant N/A OmniPath
PKN1 EGFR 10816576 11185568 12359306 1556153 16793002 17942932 18037521 18042729 1860884 20692258 21749319 23205726 27898060 2984676 2987962 3379075 6090944 7805884 inhibition N/A OmniPath
PKN1 TRAF2 14741690 27898060 N/A N/A OmniPath
PKN1 FOXO1 12560069 27898060 inhibition N/A OmniPath
PDPK1 PKN1 10467162 10753910 10764742 10792047 18669648 27898060 stimulant N/A OmniPath
PKN1 PDPK1 10753910 10764742 10792047 27898060 N/A N/A OmniPath
PKN1 CDC25C 10557092 11333986 11551930 15791647 20068231 27898060 9278512 9543386 N/A N/A OmniPath
PKN1 MAPK14 12761180 17251915 27898060 stimulant N/A OmniPath
PKN1 RAF1 11733498 15849194 27898060 stimulant N/A OmniPath
PKN1 AR 17251915 27898060 stimulant N/A OmniPath
PKN1 MAPT 11104762 11181841 12226093 12387894 12435421 19413330 19562805 27898060 9199504 9546672 9565682 9771888 9832145 inhibition N/A OmniPath
PKN1 PPP1R14A 10924361 27898060 stimulant N/A OmniPath
PKN1 SNAI1 15833848 27898060 stimulant N/A OmniPath
PKN1 MAP3K20 17251915 27898060 stimulant N/A OmniPath
PKN1 ARHGEF2 14970201 27898060 inhibition N/A OmniPath
PKN1 PGM1 15378030 27898060 stimulant N/A OmniPath
PKN1 HDAC9 20188095 27898060 N/A N/A OmniPath
PKN1 PGAM1 12189148 27898060 inhibition N/A OmniPath

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