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GENE：MT-CO2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MT-CO2
FullNmae mitochondrially encoded cytochrome c oxidase II
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7421
EnsembleID ENSG00000198712
Uniprot P00403

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MT-CO2 cuproptosis 38403151 Further analysis resulted in the identification of 6 CRGs, namely LOX, SPARC, MOXD1, ALB, MT-CO2, and AOC2. cuproptosis-related genes (CRGs)
MT-CO2 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration
MT-CO2 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
MT-CO2 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
COX5A MT-CO2 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO2 COX4I1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO2 COX5B 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO2 COX6C 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO2 COX7B 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO2 COX7C 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO2 MT-CO1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO2 MT-CO3 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO2 COX4I2 17418790 26192618 8194600 interaction type N/A ACSN
LONP1 MT-CO2 12198491 17418790 26192618 interaction type N/A ACSN
SURF1 MT-CO2 10556303 11389896 15119951 19625251 26192618 interaction type N/A ACSN
COX17 MT-CO2 15229189 18458339 19393246 26192618 interaction type N/A ACSN
SCO2 MT-CO2 15229189 18458339 19393246 26192618 interaction type N/A ACSN
SCO1 MT-CO2 15229189 18458339 19393246 26192618 interaction type N/A ACSN
ELANE MT-CO2 19506020 23180781 physical association two hybrid InnateDB
CDK2 MT-CO2 21319273 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CEBPB MT-CO2 18367585 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
FOS MT-CO2 9620167 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
HIF1A MT-CO2 16818642 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
JUNB MT-CO2 9620167 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
STAT6 MT-CO2 17237818 trascriptional regulation,stimulation chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink

Source Target Pmid Interactiontype Methods Database
URS0000008A99 MT-CO2 17875710 24616567 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002373FD MT-CO2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE MT-CO2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C3AC1 MT-CO2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000013DD8 MT-CO2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD MT-CO2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B MT-CO2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000157026 MT-CO2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA MT-CO2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 MT-CO2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 MT-CO2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003ACE11 MT-CO2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001E3523 MT-CO2 25064845 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001EFBE3 MT-CO2 25047043 25416803 25767384 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000003ABC4 MT-CO2 25416803 25483152 28255114 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009262D MT-CO2 25416803 26604791 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
COX5B MT-CO2 19688755 24234451 25348397 physical association physical interaction,blue native page ComPPI,IntAct
RPN1 MT-CO2 25348397 N/A physical interaction ComPPI
TRAF6 MT-CO2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RAD21 MT-CO2 25348397 N/A physical interaction ComPPI
COX5A MT-CO2 19688755 24234451 25348397 physical association blue native page ComPPI,IntAct
SLC38A1 MT-CO2 24234451 25348397 25561175 association anti tag coimmunoprecipitation ComPPI,IntAct
JUN MT-CO2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
LIG4 MT-CO2 25348397 N/A physical interaction ComPPI
CANX MT-CO2 25348397 N/A physical interaction ComPPI
PHB MT-CO2 25348397 N/A physical interaction ComPPI
HSP90B1 MT-CO2 25348397 N/A physical interaction ComPPI
PSMA1 MT-CO2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NELFCD MT-CO2 25348397 N/A physical interaction ComPPI
VDAC1 MT-CO2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ECT2 MT-CO2 25348397 N/A physical interaction ComPPI
RXRB MT-CO2 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
CLTC MT-CO2 25348397 N/A physical interaction ComPPI
VDAC2 MT-CO2 25348397 N/A physical interaction ComPPI
CDK2 MT-CO2 25348397 N/A physical interaction ComPPI
BCAP31 MT-CO2 25348397 N/A physical interaction ComPPI
EGFR MT-CO2 25348397 N/A physical interaction ComPPI
YWHAE MT-CO2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HTT MT-CO2 17500595 24234451 25348397 association pull down ComPPI,IntAct
PINX1 MT-CO2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
USF1 MT-CO2 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
UQCRC2 MT-CO2 25348397 N/A physical interaction ComPPI
SSR4 MT-CO2 25348397 N/A physical interaction ComPPI
RAB1B MT-CO2 25348397 N/A physical interaction ComPPI
NLGN3 MT-CO2 24234451 25348397 25464930 colocalization,association anti bait coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
CUL7 MT-CO2 25348397 N/A physical interaction ComPPI
TFEB MT-CO2 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
MT-CO1 MT-CO2 25348397 N/A physical interaction ComPPI
PTPRN MT-CO2 25348397 N/A physical interaction ComPPI
SSR1 MT-CO2 25348397 N/A physical interaction ComPPI
FAF2 MT-CO2 25348397 N/A physical interaction ComPPI
NDUFV2 MT-CO2 25348397 N/A physical interaction ComPPI
STOM MT-CO2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ATP5F1C MT-CO2 25348397 N/A physical interaction ComPPI
AIFM1 MT-CO2 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
SLC25A3 MT-CO2 25348397 N/A physical interaction ComPPI
COX4I1 MT-CO2 19688755 24234451 25348397 29568061 association,physical association physical interaction,blue native page,proximity-dependent biotin identification ComPPI,IntAct
COX6C MT-CO2 19688755 24234451 25348397 physical association blue native page ComPPI,IntAct
VDAC3 MT-CO2 25348397 N/A physical interaction ComPPI
SDHB MT-CO2 25348397 N/A physical interaction ComPPI
GPD2 MT-CO2 25348397 N/A physical interaction ComPPI
YME1L1 MT-CO2 25348397 N/A physical interaction ComPPI
NDUFS1 MT-CO2 25348397 N/A physical interaction ComPPI
FN1 MT-CO2 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
HLA-B MT-CO2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DDOST MT-CO2 25348397 N/A physical interaction ComPPI
MT-CO2 MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MT-CO2 COX20 25348397 N/A physical interaction ComPPI
MT-CO2 MAGT1 25348397 N/A physical interaction ComPPI
MT-CO2 ATP2B3 25348397 N/A physical interaction ComPPI
MT-CO2 ATP5PB 25348397 N/A physical interaction ComPPI
MT-CO2 RAB1C 25348397 N/A physical interaction ComPPI
MT-CO2 HSPB2 24234451 25348397 26465331 physical association two hybrid,physical interaction ComPPI,IntAct
MT-CO2 COA3 23260140 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MT-CO2 ZNF746 25348397 N/A physical interaction ComPPI
MT-CO2 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MT-CO2 COA6 25348397 N/A physical interaction ComPPI
MT-CO2 SCO2 25348397 N/A physical interaction ComPPI
MT-CO2 COX16 25348397 N/A physical interaction ComPPI
MT-CO2 COX7C 19688755 24234451 25348397 physical association blue native page ComPPI,IntAct
MT-CO2 COX6B1 19688755 24234451 25348397 physical association blue native page ComPPI,IntAct
MT-CO2 COX7A2 19688755 24234451 25348397 physical association blue native page ComPPI,IntAct
MT-CO2 SLC25A13 23260140 24234451 25348397 association blue native page ComPPI,IntAct
MT-CO2 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
MT-CO2 SLC11A2 24234451 24448823 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
MT-CO2 MMGT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
MT-CO2 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MT-CO2 SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RIDA MT-CO2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
METTL14 MT-CO2 24234451 29507755 association anti tag coimmunoprecipitation IntAct
MT-CO2 CCNG1 10194136 27898060 N/A N/A OmniPath

Visualization










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