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GENE：MAP4K5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP4K5
FullNmae mitogen-activated protein kinase kinase kinase kinase 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6867
EnsembleID ENSG00000012983
Uniprot Q9Y4K4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP4K5 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP4K5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP4K5 GO:0000165,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0008349,GO:0016310,GO:0035556,GO:0035556,GO:0106310

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP4K5 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP4K5 MAP3K1 23331499 9405407 stimulation N/A SignaLink
KRAS MAP4K5 23331499 9949177 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CRK MAP4K5 20005715 interaction type N/A PSP
GRB2 MAP4K5 20005715 interaction type N/A PSP
NCK1 MAP4K5 20005715 interaction type N/A PSP,SignaLink
TRAF2 MAP4K5 10477597 20005715 21071413 interaction type N/A PSP,SignaLink
GRB2 MAP4K5 20005715 N/A N/A SignaLink
CRK MAP4K5 10648385 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MAP4K5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 MAP4K5 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 MAP4K5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MAP4K5 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 MAP4K5 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MAP4K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP4K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP4K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP4K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAP4K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MAP4K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAP4K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP4K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 MAP4K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MAP4K5 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC MAP4K5 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000052EA98 MAP4K5 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 MAP4K5 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C MAP4K5 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D MAP4K5 22012620 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAP4K5 GSK3B 22135298 phosphorylation N/A PhosphoSite
GRB2 MAP4K5 25361965 interaction type N/A PTMCode2
MAP4K5 GRB2 25361965 interaction type N/A PTMCode2
CRK MAP4K5 25361965 interaction type N/A PTMCode2
MAP4K5 CRK 25361965 interaction type N/A PTMCode2
CRKL MAP4K5 25361965 interaction type N/A PTMCode2
MAP4K5 CRKL 25361965 interaction type N/A PTMCode2
BCR MAP4K5 25361965 interaction type N/A PTMCode2
MAP4K5 BCR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZNF440 MAP4K5 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CRK MAP4K5 10648385 14525934 19380743 24234451 25348397 9788432 association,physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
CRKL MAP4K5 10648385 14525934 24234451 25348397 9788432 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SETDB1 MAP4K5 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NCK1 MAP4K5 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 MAP4K5 14525934 17474147 20936779 21706016 24234451 25348397 9788432 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,peptide array,pull down,physical interaction,two hybrid pooling approach,in vitro ComPPI,HPRD,IntAct
COPS5 MAP4K5 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PPM1A MAP4K5 25348397 N/A physical interaction ComPPI
NTRK1 MAP4K5 25348397 N/A physical interaction ComPPI
CANX MAP4K5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TRAF2 MAP4K5 10477597 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BCR MAP4K5 14525934 25348397 9949177 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP4K5 TANK 10490605 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP4K5 HCK 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP4K5 NEDD4 25348397 N/A physical interaction ComPPI
MAP4K5 ELAVL1 25348397 N/A physical interaction ComPPI
MAP4K5 CDRT15 25348397 N/A physical interaction ComPPI
MAP4K5 PPM1B 25348397 N/A physical interaction ComPPI
MAP4K5 SMURF1 25348397 N/A physical interaction ComPPI
MAP4K5 MAP4K3 25348397 N/A physical interaction ComPPI
MAP4K5 FYN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
MAP4K5 ABL1 14525934 9949177 N/A experimental interaction detection HPRD
H1-2 MAP4K5 24234451 30021884 physical association cross-linking study IntAct
HNRNPU MAP4K5 24234451 30021884 physical association cross-linking study IntAct
MAP4K5 GSK3B 16914735 27898060 inhibition N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009C0D89 MAP4K5 27087310 direct interaction,inhibition N/A NPInter

Visualization










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