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GENE：MAP3K10

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP3K10
FullNmae mitogen-activated protein kinase kinase kinase 10
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6849
EnsembleID ENSG00000130758
Uniprot Q02779

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP3K10 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP3K10 GO:0003714,GO:0004672,GO:0004674,GO:0004706,GO:0004706,GO:0005515,GO:0005524,GO:0005737,GO:0006915,GO:0007165,GO:0007224,GO:0007254,GO:0018105,GO:0018107,GO:0042803,GO:0043065,GO:0043425,GO:0043433,GO:0043507,GO:0045892,GO:0045892,GO:0046330,GO:0046777,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP3K10 hsa:4294 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP3K10 hsa:4294 path:hsa05016 Huntington disease - Homo sapiens (human)
MAP3K10 hsa:4294 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP3K10 MAPK9 11278395 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MAP3K10 MAP3K10 11278395 23180781 phosphorylation reaction protein kinase assay InnateDB
MAPK1 MAP3K10 11278395 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MAP3K10 MAP2K7 23331499 9639556 stimulation N/A SignaLink,SignaLink
MAP3K10 MAP2K4 23331499 9182538 stimulation N/A SignaLink
MAPK8IP1 MAP3K10 10490659 23331499 9868371 stimulation N/A SignaLink
SH3RF1 MAP3K10 12514131 14504284 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CNKSR1 MAP3K10 20005715 interaction type N/A PSP,SignaLink
DLG4 MAP3K10 20005715 interaction type N/A PSP
HGS MAP3K10 20005715 interaction type N/A PSP,SignaLink
HTT MAP3K10 10801775 20005715 21071413 interaction type N/A PSP,SignaLink
KIFAP3 MAP3K10 20005715 interaction type N/A PSP
MAPK8IP1 MAP3K10 20005715 interaction type N/A PSP
MAPK8IP2 MAP3K10 20005715 interaction type N/A PSP
YWHAE MAP3K10 20005715 interaction type N/A PSP
KIFAP3 MAP3K10 18988627 20005715 21071413 9427749 N/A N/A SignaLink
MAPK8IP1 MAP3K10 20005715 20005715 N/A N/A SignaLink
MAPK8IP2 MAP3K10 10490659 10490659 10490659 18988627 20005715 20005715 21071413 N/A N/A SignaLink
YWHAE MAP3K10 18988627 20005715 20005715 21071413 9427749 9427749 N/A N/A SignaLink
DLG4 MAP3K10 11152698 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MAP3K10 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF MAP3K10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP3K10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAP3K10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP3K10 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 MAP3K10 20584899 23189122 23555551 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS0000338542 MAP3K10 20584899 22473208 23189122 25416803 mrna cleavage,inhibition experimental interaction detection,clip,miRNA interference luciferase reporter assay TarBase
URS00005651EE MAP3K10 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
MAP3K10 DYRK2 22135298 phosphorylation N/A PhosphoSite
MAP3K10 TCF3 22135298 phosphorylation N/A PhosphoSite
MAP3K10 MAP2K4 25361965 interaction type N/A PTMCode2
MAP2K4 MAP3K10 25361965 interaction type N/A PTMCode2
MAP3K10 CLTC 25361965 interaction type N/A PTMCode2
CLTC MAP3K10 25361965 interaction type N/A PTMCode2
MAP3K10 NEUROD1 25361965 interaction type N/A PTMCode2
NEUROD1 MAP3K10 25361965 interaction type N/A PTMCode2
MAP3K10 PHB 25361965 interaction type N/A PTMCode2
PHB MAP3K10 25361965 interaction type N/A PTMCode2
MAP3K10 CDC42 25361965 interaction type N/A PTMCode2
CDC42 MAP3K10 25361965 interaction type N/A PTMCode2
MAP3K10 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 MAP3K10 25361965 interaction type N/A PTMCode2
MAP3K10 HTT 25361965 interaction type N/A PTMCode2
HTT MAP3K10 25361965 interaction type N/A PTMCode2
MAP3K10 RAC1 25361965 interaction type N/A PTMCode2
RAC1 MAP3K10 25361965 interaction type N/A PTMCode2
MAP3K10 DNM1 25361965 interaction type N/A PTMCode2
DNM1 MAP3K10 25361965 interaction type N/A PTMCode2
MAPK8IP1 MAP3K10 25361965 interaction type N/A PTMCode2
MAP3K10 MAPK8IP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPK9 MAP3K10 25348397 N/A physical interaction ComPPI
CDC42 MAP3K10 14525934 25348397 9427749 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TUBB MAP3K10 25348397 N/A in vitro ComPPI
RAC1 MAP3K10 25348397 N/A physical interaction ComPPI
DLG4 MAP3K10 11152698 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAPK1 MAP3K10 25348397 N/A physical interaction ComPPI
RACGAP1 MAP3K10 14525934 25348397 9427749 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPK14 MAP3K10 25348397 N/A physical interaction ComPPI
HGS MAP3K10 25348397 N/A physical interaction ComPPI
KIFAP3 MAP3K10 14525934 25348397 9427749 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
MAP2K4 MAP3K10 14525934 25348397 9182538 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DNM1 MAP3K10 25348397 N/A physical interaction ComPPI
PHB MAP3K10 14525934 25348397 9629920 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP3K10 KIF3B 14525934 25348397 9427749 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
MAP3K10 DNM1L 14525934 25348397 9742220 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP3K10 YWHAE 14525934 25348397 9427749 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MAP3K10 SH3RF1 14504284 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP3K10 CEACAM1 11850617 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP3K10 CLTC 12105200 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP3K10 MAPK8IP1 10490659 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAP3K10 MAPK8IP2 10490659 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAP3K10 HTT 10801775 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K10 NEUROD1 25348397 N/A physical interaction ComPPI
MAP3K10 KIF17 25348397 N/A physical interaction ComPPI
MAP3K10 KIF3A 14525934 25348397 9427749 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
MAP3K10 HPCA 25348397 N/A physical interaction ComPPI
MAP3K10 ABL2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP3K10 MAP3K21 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP3K10 COPS2 15062575 23441852 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MAP3K10 GARS1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAP3K10 SMURF1 25348397 N/A physical interaction ComPPI
MAP3K10 TUBB2A 14525934 9629920 N/A experimental interaction detection HPRD
MAP3K10 TCF3 19801649 27898060 inhibition N/A OmniPath
MAPK9 MAP3K10 11278395 27898060 N/A N/A OmniPath
SH3RF1 MAP3K10 12514131 1450428 14504284 27898060 stimulant N/A OmniPath
MAP3K10 MAP2K4 27898060 8702571 9182538 stimulant N/A OmniPath
RAC1 MAP3K10 10799501 27898060 9427749 stimulant N/A OmniPath
MAPK1 MAP3K10 11278395 27898060 N/A N/A OmniPath
MAPK8IP1 MAP3K10 10490659 15767678 27898060 9733513 9868371 stimulant N/A OmniPath
CDC42 MAP3K10 10799501 27898060 9427749 stimulant N/A OmniPath
MAP3K10 MAP2K7 27898060 9639556 stimulant N/A OmniPath
MAP3K10 CEACAM1 11850617 27898060 N/A N/A OmniPath
MAP3K10 DLG4 11152698 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BE33C MAP3K10 27087310 direct interaction,inhibition N/A NPInter

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