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GENE：NDUFA6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NDUFA6
FullNmae NADH:ubiquinone oxidoreductase subunit A6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7690
EnsembleID ENSG00000184983
Uniprot P56556

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NDUFA6 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NDUFA6 GO:0005743,GO:0005743,GO:0005747,GO:0005747,GO:0005747,GO:0005747,GO:0006120,GO:0006979,GO:0006979,GO:0008137,GO:0009060,GO:0031966,GO:0032981,GO:0042776

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NDUFA6 hsa:4700 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
NDUFA6 hsa:4700 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NDUFA6 hsa:4700 path:hsa04714 Thermogenesis - Homo sapiens (human)
NDUFA6 hsa:4700 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
NDUFA6 hsa:4700 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
NDUFA6 hsa:4700 path:hsa05010 Alzheimer disease - Homo sapiens (human)
NDUFA6 hsa:4700 path:hsa05012 Parkinson disease - Homo sapiens (human)
NDUFA6 hsa:4700 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
NDUFA6 hsa:4700 path:hsa05016 Huntington disease - Homo sapiens (human)
NDUFA6 hsa:4700 path:hsa05020 Prion disease - Homo sapiens (human)
NDUFA6 hsa:4700 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
NDUFA6 hsa:4700 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
NDUFA6 hsa:4700 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MT-ND1 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND2 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND3 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4L NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND5 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND6 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA1 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA4 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFA10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFA11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFA12 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFA13 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFA2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFA3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFA5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFA9 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFAB1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFB11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFB3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFB7 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFB8 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFS3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFS5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFS7 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFV1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA7 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA8 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB1 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB2 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB9 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFC1 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS1 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS4 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS8 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFV2 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFV3 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
GZMA NDUFA6 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
NDUFAF2 NDUFA6 15526035 16200211 16218961 17344420 20025615 20816094 26192618 interaction type N/A ACSN
ACAD9 NDUFA6 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
ECSIT NDUFA6 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
NDUFAF1 NDUFA6 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
AIFM1 NDUFA6 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
SMARCA4 NDUFA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NDUFA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NDUFA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NDUFA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NDUFA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000FC8EB NDUFA6 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 NDUFA6 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000243FF1 NDUFA6 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NDUFA2 NDUFA6 25361965 interaction type N/A PTMCode2
NDUFA6 NDUFA2 25361965 interaction type N/A PTMCode2
NDUFAB1 NDUFA6 25361965 interaction type N/A PTMCode2
NDUFA6 NDUFAB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NDUFB9 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFAF4 NDUFA6 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
JUN NDUFA6 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
VAPA NDUFA6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NIT1 NDUFA6 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
BAG6 NDUFA6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MT-ND1 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TOM1L2 NDUFA6 25348397 N/A physical interaction ComPPI
PDK1 NDUFA6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TBPL1 NDUFA6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NDUFS7 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
AURKAIP1 NDUFA6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MT-ND3 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MT-ND4 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA13 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
HSPD1 NDUFA6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFV2 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFV1 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFB1 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ATP5MF NDUFA6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NDUFAF1 NDUFA6 17557076 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA5 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFB3 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFS6 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MGST3 NDUFA6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFV3 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA1 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 MTCH2 25348397 N/A physical interaction ComPPI
NDUFA6 NDUFA12 12611891 24234451 24344204 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFA6 NDUFA9 12611891 24234451 24344204 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFA6 SDHB 25348397 N/A physical interaction ComPPI
NDUFA6 HSPB2 24234451 25348397 26465331 physical association two hybrid,physical interaction ComPPI,IntAct
NDUFA6 NDUFS5 12611891 24234451 24344204 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFA6 NDUFA11 12611891 24234451 24344204 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFA6 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFA6 NDUFS3 12611891 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFA6 NDUFA4 12611891 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFA6 NMES1 25348397 N/A physical interaction ComPPI
NDUFA6 COX6B1 25348397 N/A physical interaction ComPPI
NDUFA6 NDUFB11 12611891 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFA6 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFA2 12611891 19688755 24234451 25348397 association,physical association anti bait coimmunoprecipitation,blue native page ComPPI,IntAct
NDUFA6 NDUFB8 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFAB1 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFB7 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 MT-ND2 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFS4 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFC2 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFA3 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 MT-ND5 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFS8 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFB6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFA7 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFA10 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFB5 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFB2 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFA8 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFB4 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFS1 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFS2 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFB10 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFA6 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFA6 DHRS4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
TRMT61B NDUFA6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HSCB NDUFA6 24234451 25348397 28380382 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct

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