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GENE：MEF2A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MEF2A
FullNmae myocyte enhancer factor 2A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6993
EnsembleID ENSG00000068305
Uniprot Q02078

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MEF2A necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MEF2A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MEF2A GO:0000002,GO:0000122,GO:0000165,GO:0000785,GO:0000785,GO:0000977,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001228,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0005829,GO:0006351,GO:0006915,GO:0007507,GO:0007507,GO:0007517,GO:0010613,GO:0010613,GO:0010628,GO:0019901,GO:0030154,GO:0035035,GO:0042826,GO:0042826,GO:0043565,GO:0045944,GO:0045944,GO:0046326,GO:0046332,GO:0046982,GO:0048311,GO:0048813,GO:0055005,GO:0061337,GO:0061629,GO:0070375,GO:0071277,GO:0140297

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MEF2A hsa:4205 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
MEF2A hsa:4205 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
MEF2A hsa:4205 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
MEF2A hsa:4205 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ERBIN MEF2A 15123239 23180781 physical association peptide array InnateDB
MAPK7 MEF2A 10849446 18988627 23331499 9753748 9858528 stimulation N/A SignaLink,SignaLink
SMAD4 MEF2A 11160896 23331499 stimulation N/A SignaLink
SMAD2 MEF2A 11160896 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MEF2A 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MEF2A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYCN MEF2A 16093321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MEF2A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 MEF2A 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MEF2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC4 MEF2A 10748098 17179159 trascriptional regulation,stimulation inferred by curator TFlink
HDAC5 MEF2A 10748098 15194749 trascriptional regulation,stimulation inferred by curator TFlink
HDAC7 MEF2A 11585834 trascriptional regulation,stimulation inferred by curator TFlink
HDAC9 MEF2A 11585834 12242305 15194749 trascriptional regulation,stimulation inferred by curator TFlink
MEF2A MEF2A 18222924 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 MEF2A 20584899 rna interference,inhibition experimental interaction detection miRSponge
URS0000237AF9 MEF2A 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 MEF2A 20584899 22473208 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS0000028BB8 MEF2A 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS000009262D MEF2A 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS0000065D58 MEF2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000006FDD4 MEF2A 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 MEF2A 22135298 phosphorylation N/A PhosphoSite
MAPK14 MEF2A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
CDK5 MEF2A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK7 MEF2A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MEF2A TEAD1 25361965 interaction type N/A PTMCode2
TEAD1 MEF2A 25361965 interaction type N/A PTMCode2
MEF2A SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 MEF2A 25361965 interaction type N/A PTMCode2
HDAC7 MEF2A 25361965 interaction type N/A PTMCode2
MEF2A HDAC7 25361965 interaction type N/A PTMCode2
MEF2A MAPK7 25361965 interaction type N/A PTMCode2
MYOD1 MEF2A 25361965 interaction type N/A PTMCode2
MEF2A MYOD1 25361965 interaction type N/A PTMCode2
HDAC5 MEF2A 25361965 interaction type N/A PTMCode2
MEF2A HDAC5 25361965 interaction type N/A PTMCode2
MEF2A MAPK14 25361965 interaction type N/A PTMCode2
ASCL1 MEF2A 25361965 interaction type N/A PTMCode2
MEF2A ASCL1 25361965 interaction type N/A PTMCode2
MEF2A CDK5 25361965 interaction type N/A PTMCode2
HDAC4 MEF2A 25361965 interaction type N/A PTMCode2
MEF2A HDAC4 25361965 interaction type N/A PTMCode2
CABIN1 MEF2A 25361965 interaction type N/A PTMCode2
MEF2A CABIN1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I MEF2A 25348397 N/A nuclear magnetic resonance,physical interaction,physical interaction ComPPI
NDUFB9 MEF2A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MYOG MEF2A 1329097 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
SMAD4 MEF2A 11160896 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
H2BC4 MEF2A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ERBIN MEF2A 25348397 N/A physical interaction ComPPI
PRKCQ MEF2A 20178747 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TBP MEF2A 25348397 N/A physical interaction ComPPI
MYOD1 MEF2A 14525934 25348397 8548800 9418854 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP3 MEF2A 11904443 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
JUN MEF2A 24234451 25348397 25609649 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
SMAD2 MEF2A 11160896 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SUMO1 MEF2A 14525934 16484498 17036045 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,comigration in sds page ComPPI,HPRD,IntAct
EP300 MEF2A 12371907 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ATF3 MEF2A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HDAC3 MEF2A 25348397 N/A physical interaction ComPPI
MAPK14 MEF2A 10330143 10849446 14525934 25348397 9858528 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
JUND MEF2A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HDAC4 MEF2A 10487761 11792813 14525934 24234451 25348397 colocalization anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,HPRD,IntAct
ITGB1 MEF2A 25348397 N/A physical interaction ComPPI
HIRA MEF2A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
THRA MEF2A 12371907 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACTN4 MEF2A 25348397 N/A physical interaction ComPPI
CASP7 MEF2A 11904443 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HNRNPL MEF2A 25348397 N/A physical interaction ComPPI
HAND1 MEF2A 16043483 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PKM MEF2A 25348397 N/A protein kinase assay ComPPI
XPO1 MEF2A 25348397 N/A physical interaction ComPPI
MAPK7 MEF2A 10849446 14525934 25348397 9753748 9858528 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SUMO2 MEF2A 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
H3-4 MEF2A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
PHB2 MEF2A 25348397 N/A physical interaction,in vivo ComPPI
MEF2C MEF2A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2D MEF2A 14525934 24234451 25348397 25609649 8798771 9858528 association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
MEF2A HDAC9 10825153 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MEF2A HDAC5 10737771 10748098 14525934 24234451 25348397 25609649 association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
MEF2A ASCL1 14525934 25348397 27898060 8662987 8900141 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
MEF2A CDK5 12691662 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MEF2A VGLL4 25348397 N/A physical interaction ComPPI
MEF2A HDAC7 25348397 N/A physical interaction ComPPI
MEF2A HDAC1 25348397 N/A physical interaction ComPPI
MEF2A HNRNPA1 25348397 N/A physical interaction ComPPI
MEF2A DDB1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MEF2A GNB2 25348397 N/A physical interaction ComPPI
MEF2A TAF8 25348397 N/A physical interaction ComPPI
MEF2A KLC4 25348397 N/A physical interaction ComPPI
MEF2A ATF7 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2A CABIN1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2A H2BC1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2A REV3L 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2A SH2B1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2A H2BC11 25348397 N/A physical interaction ComPPI
MEF2A CCDC15 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2A MAPKAPK3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2A SETX 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2A TTLL7 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2A ZCWPW1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2A MEF2B 25348397 N/A physical interaction ComPPI
MEF2A XYLT1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEF2A DNMT3L 25348397 N/A physical interaction ComPPI
MEF2A TSR3 25348397 N/A physical interaction ComPPI
MEF2A PITX2 25348397 N/A two hybrid ComPPI
GNG12 MEF2A 25348397 N/A physical interaction ComPPI
MEF2A MEF2A 14525934 24234451 25609649 8575763 association experimental interaction detection,tandem affinity purification HPRD,IntAct
CDK5 MEF2A 12586839 12691662 16371476 16484498 27898060 inhibition,stimulant N/A OmniPath
MEF2A SLC2A4 17317207 27898060 stimulant N/A OmniPath
MEF2A MYOD1 27898060 8548800 9418854 stimulant N/A OmniPath
CASP3 MEF2A 11904443 27898060 N/A N/A OmniPath
MAPK7 MEF2A 10330143 10849446 12586839 17785444 27898060 9753748 9858528 stimulant N/A OmniPath
MAPK14 MEF2A 10330143 10849446 12586839 15340086 16484498 17785444 18669648 27898060 9858528 inhibition,stimulant N/A OmniPath
SMAD2 MEF2A 11160896 27898060 stimulant N/A OmniPath
HDAC4 MEF2A 10487761 10737771 10748098 11792813 19389706 22466704 27898060 inhibition N/A OmniPath
CDK4 MEF2A 21902831 27898060 inhibition N/A OmniPath
EP300 MEF2A 11796223 12371907 20590529 27898060 stimulant N/A OmniPath
CSNK2A1 MEF2A 12586839 27898060 N/A N/A OmniPath
SMAD4 MEF2A 11160896 27898060 stimulant N/A OmniPath
NLK MEF2A 10330143 10849446 12586839 17785444 27898060 9858528 N/A N/A OmniPath
NFATC2 MEF2A 11796223 27898060 stimulant N/A OmniPath
HDAC5 MEF2A 10737771 10748098 11062529 12626519 21233771 22308472 25609649 27898060 inhibition N/A OmniPath
ERBIN MEF2A 15123239 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008BDCDE MEF2A 27087310 direct interaction,inhibition N/A NPInter

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