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GENE：NDUFB10

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NDUFB10
FullNmae NADH:ubiquinone oxidoreductase subunit B10
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7696
EnsembleID ENSG00000140990
Uniprot O96000

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NDUFB10 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
NDUFB10 cuproptosis 36118866 FeS Cluster cuproptosis gene
NDUFB10 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NDUFB10 GO:0005515,GO:0005743,GO:0005743,GO:0005743,GO:0005747,GO:0005747,GO:0005747,GO:0005747,GO:0006120,GO:0008137,GO:0009060,GO:0032981,GO:0042776

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NDUFB10 hsa:4716 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
NDUFB10 hsa:4716 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NDUFB10 hsa:4716 path:hsa04714 Thermogenesis - Homo sapiens (human)
NDUFB10 hsa:4716 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
NDUFB10 hsa:4716 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
NDUFB10 hsa:4716 path:hsa05010 Alzheimer disease - Homo sapiens (human)
NDUFB10 hsa:4716 path:hsa05012 Parkinson disease - Homo sapiens (human)
NDUFB10 hsa:4716 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
NDUFB10 hsa:4716 path:hsa05016 Huntington disease - Homo sapiens (human)
NDUFB10 hsa:4716 path:hsa05020 Prion disease - Homo sapiens (human)
NDUFB10 hsa:4716 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
NDUFB10 hsa:4716 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
NDUFB10 hsa:4716 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MT-ND1 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND2 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND3 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4L NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND5 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND6 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA1 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA11 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA12 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA13 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA2 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA3 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA4 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA5 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA7 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA8 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA9 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFAB1 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB1 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB10 NDUFA10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB10 NDUFB11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB10 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB2 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB3 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB7 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB8 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB9 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFC1 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS1 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS3 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS4 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS5 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS6 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS7 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS8 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFV1 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFV2 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFV3 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
GZMA NDUFB10 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
NDUFAF2 NDUFB10 15526035 16200211 16218961 17344420 20025615 20816094 26192618 interaction type N/A ACSN
ACAD9 NDUFB10 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
ECSIT NDUFB10 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
NDUFAF1 NDUFB10 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
AIFM1 NDUFB10 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389 26192618 interaction type N/A ACSN
NDUFB10 TSC1 17355907 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 NDUFB10 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF NDUFB10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NDUFB10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NDUFB10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 NDUFB10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NDUFB10 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000028BB8 NDUFB10 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EC1BE NDUFB10 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
NDUFA2 NDUFB10 25361965 interaction type N/A PTMCode2
NDUFB10 NDUFA2 25361965 interaction type N/A PTMCode2
NDUFAB1 NDUFB10 25361965 interaction type N/A PTMCode2
NDUFB10 NDUFAB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NDUFB9 NDUFB10 25348397 N/A physical interaction ComPPI
ATP5PO NDUFB10 25348397 N/A physical interaction ComPPI
NDUFAF3 NDUFB10 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TIMMDC1 NDUFB10 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFAF4 NDUFB10 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPM2 NDUFB10 25348397 N/A physical interaction ComPPI
LIG4 NDUFB10 25348397 N/A physical interaction ComPPI
PTPN22 NDUFB10 25348397 N/A physical interaction ComPPI
NIT1 NDUFB10 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
MAPK6 NDUFB10 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
TPM3 NDUFB10 25348397 N/A physical interaction ComPPI
HTR2A NDUFB10 14525934 16537434 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
BCAP31 NDUFB10 25348397 N/A physical interaction ComPPI
HTT NDUFB10 17500595 24234451 25348397 association pull down ComPPI,IntAct
YBX3 NDUFB10 25348397 N/A physical interaction ComPPI
TSC1 NDUFB10 17355907 24234451 25348397 physical association two hybrid ComPPI,IntAct
UPF1 NDUFB10 25348397 N/A physical interaction ComPPI
XRN1 NDUFB10 25348397 N/A physical interaction ComPPI
FKBP8 NDUFB10 25348397 N/A physical interaction ComPPI
NDUFS7 NDUFB10 25348397 N/A physical interaction ComPPI
TPM4 NDUFB10 25348397 N/A physical interaction ComPPI
NDUFV2 NDUFB10 25348397 N/A physical interaction ComPPI
NDUFV1 NDUFB10 25348397 N/A physical interaction ComPPI
NDUFA5 NDUFB10 25348397 N/A physical interaction ComPPI
AIFM1 NDUFB10 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SLC25A3 NDUFB10 25348397 N/A physical interaction ComPPI
CYC1 NDUFB10 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFB10 25348397 N/A physical interaction ComPPI
NDUFA6 NDUFB10 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFB10 NDUFB11 25348397 N/A physical interaction ComPPI
NDUFB10 NDUFS1 25348397 N/A physical interaction ComPPI
NDUFB10 NDUFB7 25348397 N/A physical interaction ComPPI
NDUFB10 MTARC1 25348397 N/A physical interaction ComPPI
NDUFB10 UQCC3 25348397 N/A physical interaction ComPPI
NDUFB10 MRPL13 25348397 N/A physical interaction ComPPI
NDUFB10 FAM9B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NDUFB10 NDUFS3 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB10 MRPS7 25348397 N/A physical interaction ComPPI
NDUFB10 NDUFA9 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB10 TPM1 25348397 N/A physical interaction ComPPI
NDUFB10 NDUFA12 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB10 NDUFS4 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB10 NDUFS5 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB10 NDUFA4 25348397 N/A physical interaction ComPPI
NDUFB10 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFB10 UBE2DNL 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
NDUFB10 NDUFA2 19688755 24234451 25348397 physical association blue native page ComPPI,IntAct
NDUFB10 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFB10 DUX4L9 24234451 25348397 26816005 physical association two hybrid ComPPI,IntAct
NDUFB10 POLR1C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NDUFB10 NDUFAF5 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
HSCB NDUFB10 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFB10 TSC1 17355907 27898060 N/A N/A OmniPath
TSC1 NDUFB10 17355907 27898060 N/A N/A OmniPath

Visualization










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