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GENE：NDUFB4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NDUFB4
FullNmae NADH:ubiquinone oxidoreductase subunit B4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7699
EnsembleID ENSG00000065518
Uniprot O95168

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NDUFB4 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NDUFB4 GO:0005654,GO:0005739,GO:0005739,GO:0005743,GO:0005743,GO:0005747,GO:0005747,GO:0005747,GO:0005747,GO:0006120,GO:0006979,GO:0008137,GO:0009060,GO:0032981,GO:0042776

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NDUFB4 hsa:4710 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
NDUFB4 hsa:4710 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NDUFB4 hsa:4710 path:hsa04714 Thermogenesis - Homo sapiens (human)
NDUFB4 hsa:4710 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
NDUFB4 hsa:4710 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
NDUFB4 hsa:4710 path:hsa05010 Alzheimer disease - Homo sapiens (human)
NDUFB4 hsa:4710 path:hsa05012 Parkinson disease - Homo sapiens (human)
NDUFB4 hsa:4710 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
NDUFB4 hsa:4710 path:hsa05016 Huntington disease - Homo sapiens (human)
NDUFB4 hsa:4710 path:hsa05020 Prion disease - Homo sapiens (human)
NDUFB4 hsa:4710 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
NDUFB4 hsa:4710 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
NDUFB4 hsa:4710 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MT-ND1 NDUFB4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND2 NDUFB4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND3 NDUFB4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4 NDUFB4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4L NDUFB4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND5 NDUFB4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND6 NDUFB4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA1 NDUFB4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFA10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFA11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFA12 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFA13 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFA2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFA3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFA4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFA5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFA7 12601012 12667446 15186778 15526035 15807660 16200211 16218961 16246152 17344420 18485875 19131594 20025615 20816094 23850759 26192618 interaction type N/A ACSN
NDUFB4 NDUFA8 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFA9 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFAB1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFB1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFB11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFB2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFB3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFB6 12601012 12667446 15186778 15526035 15807660 16200211 16218961 16246152 17344420 18485875 19131594 20025615 20816094 23850759 26192618 interaction type N/A ACSN
NDUFB4 NDUFB7 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFB8 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFC1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFS3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFS4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFS5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFS7 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFV1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFV2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFV3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFB4 12601012 12667446 15186778 15526035 15807660 16200211 16218961 16246152 17344420 18485875 19131594 20025615 20816094 23850759 26192618 interaction type N/A ACSN
NDUFB9 NDUFB4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS1 NDUFB4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS8 NDUFB4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 EIF2B1 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
NDUFB4 EIF2S1 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
NDUFB4 EIF2S2 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
GZMA NDUFB4 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
NDUFAF2 NDUFB4 15526035 16200211 16218961 17344420 20025615 20816094 26192618 interaction type N/A ACSN
ACAD9 NDUFB4 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
ECSIT NDUFB4 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
NDUFAF1 NDUFB4 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
AIFM1 NDUFB4 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389 26192618 interaction type N/A ACSN
EIF2S3 NDUFB4 26192618 association N/A ACSN
EIF2B3 NDUFB4 26192618 association N/A ACSN
EIF2B4 NDUFB4 26192618 association N/A ACSN
EIF2B5 NDUFB4 26192618 association N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 NDUFB4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 NDUFB4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 NDUFB4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NDUFB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NDUFB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NDUFB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NDUFB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NDUFB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 NDUFB4 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
NDUFAB1 NDUFB4 25361965 interaction type N/A PTMCode2
NDUFB4 NDUFAB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BAG3 NDUFB4 25348397 N/A physical interaction ComPPI
TIMMDC1 NDUFB4 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFAF4 NDUFB4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
VAPA NDUFB4 25348397 N/A physical interaction ComPPI
ABCD1 NDUFB4 25348397 N/A physical interaction ComPPI
RAB7A NDUFB4 25348397 N/A physical interaction ComPPI
NIT1 NDUFB4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PHB NDUFB4 25348397 N/A physical interaction ComPPI
LAMTOR3 NDUFB4 25348397 N/A physical interaction ComPPI
VDAC1 NDUFB4 25348397 N/A physical interaction ComPPI
MME NDUFB4 17342744 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TOMM20 NDUFB4 25348397 N/A physical interaction ComPPI
PPP4R1 NDUFB4 25348397 N/A physical interaction ComPPI
TCF3 NDUFB4 25348397 N/A physical interaction ComPPI
MYL12B NDUFB4 25348397 N/A physical interaction ComPPI
M6PR NDUFB4 25348397 N/A physical interaction ComPPI
NDUFV2 NDUFB4 25348397 N/A physical interaction ComPPI
NDUFV1 NDUFB4 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRFS1 NDUFB4 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFB4 25348397 N/A physical interaction ComPPI
NDUFA6 NDUFB4 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
KSR1 NDUFB4 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
MYL12A NDUFB4 25348397 N/A physical interaction ComPPI
NDUFA9 NDUFB4 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RIPK4 NDUFB4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
LRRK2 NDUFB4 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
NDUFS3 NDUFB4 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MTARC1 NDUFB4 25348397 N/A physical interaction ComPPI
NDUFA8 NDUFB4 25348397 N/A physical interaction ComPPI
NDUFB4 MPV17 25348397 N/A physical interaction ComPPI
NDUFB4 ENPP6 25348397 N/A physical interaction ComPPI
NDUFB4 RPGRIP1L 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NDUFB4 NDUFA12 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB4 NDUFS4 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB4 NDUFS5 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB4 NDUFA11 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB4 GOLT1B 25348397 N/A physical interaction ComPPI
NDUFB4 NDUFA4 25348397 N/A physical interaction ComPPI
NDUFB4 NMES1 25348397 N/A physical interaction ComPPI
NDUFB4 NDUFB11 25348397 N/A physical interaction ComPPI
NDUFB4 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
HSCB NDUFB4 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct

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