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GENE：NDUFB5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NDUFB5
FullNmae NADH:ubiquinone oxidoreductase subunit B5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7700
EnsembleID ENSG00000136521
Uniprot O43674

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NDUFB5 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NDUFB5 GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005743,GO:0005747,GO:0005747,GO:0005747,GO:0005747,GO:0006120,GO:0008137,GO:0009060,GO:0032981,GO:0042776

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NDUFB5 hsa:4711 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
NDUFB5 hsa:4711 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NDUFB5 hsa:4711 path:hsa04714 Thermogenesis - Homo sapiens (human)
NDUFB5 hsa:4711 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
NDUFB5 hsa:4711 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
NDUFB5 hsa:4711 path:hsa05010 Alzheimer disease - Homo sapiens (human)
NDUFB5 hsa:4711 path:hsa05012 Parkinson disease - Homo sapiens (human)
NDUFB5 hsa:4711 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
NDUFB5 hsa:4711 path:hsa05016 Huntington disease - Homo sapiens (human)
NDUFB5 hsa:4711 path:hsa05020 Prion disease - Homo sapiens (human)
NDUFB5 hsa:4711 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
NDUFB5 hsa:4711 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
NDUFB5 hsa:4711 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MT-ND1 NDUFB5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND2 NDUFB5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND3 NDUFB5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4 NDUFB5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4L NDUFB5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND5 NDUFB5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND6 NDUFB5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA1 NDUFB5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFA10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFA11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFA12 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFA13 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFA2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFA3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFA4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFA5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFA7 12601012 12667446 15186778 15526035 15807660 16200211 16218961 16246152 17344420 18485875 19131594 20025615 20816094 23850759 26192618 interaction type N/A ACSN
NDUFB5 NDUFA8 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFA9 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFAB1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFB1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFB11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFB2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFB3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFB4 12601012 12667446 15186778 15526035 15807660 16200211 16218961 16246152 17344420 18485875 19131594 20025615 20816094 23850759 26192618 interaction type N/A ACSN
NDUFB5 NDUFB6 12601012 12667446 15186778 15526035 15807660 16200211 16218961 16246152 17344420 18485875 19131594 20025615 20816094 23850759 26192618 interaction type N/A ACSN
NDUFB5 NDUFB7 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFB8 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFC1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFS3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFS4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFS5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFS7 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFV1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFV2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFV3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB9 NDUFB5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS1 NDUFB5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS8 NDUFB5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 EIF2B1 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
NDUFB5 EIF2S1 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
NDUFB5 EIF2S2 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
GZMA NDUFB5 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
NDUFAF2 NDUFB5 15526035 16200211 16218961 17344420 20025615 20816094 26192618 interaction type N/A ACSN
ACAD9 NDUFB5 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
ECSIT NDUFB5 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
NDUFAF1 NDUFB5 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
AIFM1 NDUFB5 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389 26192618 interaction type N/A ACSN
EIF2S3 NDUFB5 26192618 association N/A ACSN
EIF2B3 NDUFB5 26192618 association N/A ACSN
EIF2B4 NDUFB5 26192618 association N/A ACSN
EIF2B5 NDUFB5 26192618 association N/A ACSN

Source Target Pmid Interactiontype Methods Database
GATA2 NDUFB5 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 NDUFB5 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NDUFB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NDUFB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NDUFB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC NDUFB5 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000272039 NDUFB5 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000170CF4 NDUFB5 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000003ABC4 NDUFB5 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000054DF42 NDUFB5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032FC1A NDUFB5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C NDUFB5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C4762 NDUFB5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000610EFA NDUFB5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000019F055 NDUFB5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000076995 NDUFB5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 NDUFB5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 NDUFB5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 NDUFB5 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C NDUFB5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000568FF8 NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000453664 NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003003B4 NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047944F NDUFB5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001EB9FC NDUFB5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00003677B2 NDUFB5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001CF056 NDUFB5 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NDUFA2 NDUFB5 25361965 interaction type N/A PTMCode2
NDUFB5 NDUFA2 25361965 interaction type N/A PTMCode2
NDUFAB1 NDUFB5 25361965 interaction type N/A PTMCode2
NDUFB5 NDUFAB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NDUFB9 NDUFB5 25348397 N/A physical interaction ComPPI
YIPF3 NDUFB5 25348397 N/A physical interaction ComPPI
NCALD NDUFB5 25348397 N/A physical interaction ComPPI
SCAND1 NDUFB5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TIMMDC1 NDUFB5 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFAF4 NDUFB5 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DLD NDUFB5 25348397 N/A physical interaction ComPPI
NIT1 NDUFB5 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
LAMTOR3 NDUFB5 25348397 N/A physical interaction ComPPI
HNRNPL NDUFB5 25348397 N/A physical interaction ComPPI
SYNCRIP NDUFB5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN NDUFB5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3I NDUFB5 25348397 N/A physical interaction ComPPI
UQCRC2 NDUFB5 25348397 N/A physical interaction ComPPI
HDAC10 NDUFB5 25348397 N/A physical interaction ComPPI
ECSIT NDUFB5 25348397 N/A physical interaction ComPPI
NDUFS7 NDUFB5 25348397 N/A physical interaction ComPPI
SORT1 NDUFB5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MARCKSL1 NDUFB5 25348397 N/A physical interaction ComPPI
GALNT6 NDUFB5 25348397 N/A physical interaction ComPPI
MT-ND4 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFA13 NDUFB5 25348397 N/A physical interaction ComPPI
MSLN NDUFB5 25348397 N/A physical interaction ComPPI
NDUFB1 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFAF1 NDUFB5 25348397 N/A physical interaction ComPPI
C3AR1 NDUFB5 25348397 N/A physical interaction ComPPI
SLC25A3 NDUFB5 25348397 N/A physical interaction ComPPI
MRPS26 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFB3 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFA6 NDUFB5 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFB8 NDUFB5 25348397 N/A physical interaction ComPPI
TACR1 NDUFB5 25348397 N/A physical interaction ComPPI
LPAR1 NDUFB5 25348397 N/A physical interaction ComPPI
MTCH2 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFB10 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFS1 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFA9 NDUFB5 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP5PB NDUFB5 25348397 N/A physical interaction ComPPI
ACAD9 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFB6 NDUFB5 25348397 N/A physical interaction ComPPI
MT-ND5 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFS3 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFA8 NDUFB5 25348397 N/A physical interaction ComPPI
MRPL58 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFA12 NDUFB5 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFA2 NDUFB5 19688755 24234451 25348397 physical association blue native page ComPPI,IntAct
NDUFB11 NDUFB5 25348397 N/A physical interaction ComPPI
FUT1 NDUFB5 25348397 N/A physical interaction ComPPI
SAMD1 NDUFB5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFC2 NDUFB5 25348397 N/A physical interaction ComPPI
PSMG3 NDUFB5 25348397 N/A physical interaction ComPPI
FAM174A NDUFB5 25348397 N/A physical interaction ComPPI
NDUFA4 NDUFB5 25348397 N/A physical interaction ComPPI
ATP5F1D NDUFB5 25348397 N/A physical interaction ComPPI
NDUFS4 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFB7 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFB5 MPV17 25348397 N/A physical interaction ComPPI
NDUFB5 ENPP6 25348397 N/A physical interaction ComPPI
NDUFB5 NDUFS5 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB5 NDUFA11 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB5 ITM2A 25348397 N/A physical interaction ComPPI
NDUFB5 NDUFAF5 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
HSCB NDUFB5 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct

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