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GENE：NDUFB6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NDUFB6
FullNmae NADH:ubiquinone oxidoreductase subunit B6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7701
EnsembleID ENSG00000165264
Uniprot O95139

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NDUFB6 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NDUFB6 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
NDUFB6 cuproptosis 36118866 FeS Cluster cuproptosis gene
NDUFB6 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NDUFB6 GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005743,GO:0005747,GO:0005747,GO:0005747,GO:0005747,GO:0005747,GO:0006120,GO:0008137,GO:0009060,GO:0031966,GO:0032981,GO:0042775,GO:0042775,GO:0042776

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NDUFB6 hsa:4712 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
NDUFB6 hsa:4712 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NDUFB6 hsa:4712 path:hsa04714 Thermogenesis - Homo sapiens (human)
NDUFB6 hsa:4712 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
NDUFB6 hsa:4712 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
NDUFB6 hsa:4712 path:hsa05010 Alzheimer disease - Homo sapiens (human)
NDUFB6 hsa:4712 path:hsa05012 Parkinson disease - Homo sapiens (human)
NDUFB6 hsa:4712 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
NDUFB6 hsa:4712 path:hsa05016 Huntington disease - Homo sapiens (human)
NDUFB6 hsa:4712 path:hsa05020 Prion disease - Homo sapiens (human)
NDUFB6 hsa:4712 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
NDUFB6 hsa:4712 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
NDUFB6 hsa:4712 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MT-ND1 NDUFB6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND2 NDUFB6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND3 NDUFB6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4 NDUFB6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4L NDUFB6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND5 NDUFB6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND6 NDUFB6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA1 NDUFB6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFB6 12601012 12667446 15186778 15526035 15807660 16200211 16218961 16246152 17344420 18485875 19131594 20025615 20816094 23850759 26192618 interaction type N/A ACSN
NDUFB5 NDUFB6 12601012 12667446 15186778 15526035 15807660 16200211 16218961 16246152 17344420 18485875 19131594 20025615 20816094 23850759 26192618 interaction type N/A ACSN
NDUFB6 NDUFA10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFA11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFA12 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFA13 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFA2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFA3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFA4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFA5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFA7 12601012 12667446 15186778 15526035 15807660 16200211 16218961 16246152 17344420 18485875 19131594 20025615 20816094 23850759 26192618 interaction type N/A ACSN
NDUFB6 NDUFA8 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFA9 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFAB1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFB1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFB11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFB2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFB3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFB7 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFB8 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFC1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFS3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 23180781 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
NDUFB6 NDUFS4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFS5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFS7 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFV1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFV2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFV3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB9 NDUFB6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS1 NDUFB6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS8 NDUFB6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 EIF2B1 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
NDUFB6 EIF2S1 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
NDUFB6 EIF2S2 12601012 12667446 16246152 23850759 26192618 interaction type N/A ACSN
GZMA NDUFB6 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
NDUFAF2 NDUFB6 15526035 16200211 16218961 17344420 20025615 20816094 26192618 interaction type N/A ACSN
ACAD9 NDUFB6 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
ECSIT NDUFB6 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
NDUFAF1 NDUFB6 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
AIFM1 NDUFB6 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389 26192618 interaction type N/A ACSN
EIF2S3 NDUFB6 26192618 association N/A ACSN
EIF2B3 NDUFB6 26192618 association N/A ACSN
EIF2B4 NDUFB6 26192618 association N/A ACSN
EIF2B5 NDUFB6 26192618 association N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 NDUFB6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP53 NDUFB6 18922183 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 NDUFB6 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NDUFB6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NDUFB6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NDUFB6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NDUFB6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NDUFB6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NDUFB6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NDUFB6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NDUFB6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 NDUFB6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001F0C23 NDUFB6 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000016D2D4 NDUFB6 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000021D7C8 NDUFB6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 NDUFB6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E1509 NDUFB6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 NDUFB6 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED NDUFB6 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NDUFAB1 NDUFB6 25361965 interaction type N/A PTMCode2
NDUFB6 NDUFAB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
YIPF3 NDUFB6 25348397 N/A physical interaction ComPPI
TIMMDC1 NDUFB6 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PON1 NDUFB6 25348397 N/A physical interaction ComPPI
ABCB7 NDUFB6 25348397 N/A physical interaction ComPPI
CREB3 NDUFB6 25348397 N/A physical interaction ComPPI
SNCA NDUFB6 25348397 N/A physical interaction ComPPI
NDUFS7 NDUFB6 25348397 N/A physical interaction ComPPI
GALNT6 NDUFB6 25348397 N/A physical interaction ComPPI
NDUFA13 NDUFB6 25348397 N/A physical interaction ComPPI
NDUFV1 NDUFB6 25348397 N/A physical interaction ComPPI
NDUFAF1 NDUFB6 17557076 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFS6 NDUFB6 25348397 N/A physical interaction ComPPI
NDUFA6 NDUFB6 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SDHB NDUFB6 25348397 N/A physical interaction ComPPI
YME1L1 NDUFB6 25348397 N/A physical interaction ComPPI
APP NDUFB6 25348397 N/A physical interaction ComPPI
TMBIM4 NDUFB6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ERGIC3 NDUFB6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NDUFB6 NDUFS3 18485875 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB6 MRPS28 25348397 N/A physical interaction ComPPI
NDUFB6 IKBIP 25348397 N/A physical interaction ComPPI
NDUFB6 MPV17 25348397 N/A physical interaction ComPPI
NDUFB6 NDUFA8 25348397 N/A physical interaction ComPPI
NDUFB6 NDUFA12 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB6 NDUFS5 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB6 NDUFA11 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB6 NDUFB11 25348397 N/A physical interaction ComPPI
NDUFB6 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFB6 FUT1 25348397 N/A physical interaction ComPPI
HSCB NDUFB6 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
GAPDH NDUFB6 24234451 30021884 physical association cross-linking study IntAct

Visualization










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