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GENE：NDUFC2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NDUFC2
FullNmae NADH:ubiquinone oxidoreductase subunit C2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7706
EnsembleID ENSG00000151366
Uniprot O95298

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NDUFC2 cuproptosis 36118866 FeS Cluster cuproptosis gene
NDUFC2 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NDUFC2 GO:0005515,GO:0005737,GO:0005739,GO:0005743,GO:0005743,GO:0005747,GO:0005747,GO:0005747,GO:0005747,GO:0005886,GO:0006120,GO:0008137,GO:0009060,GO:0032981,GO:0035577,GO:0042776

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NDUFC2 hsa:4718 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
NDUFC2 hsa:4718 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NDUFC2 hsa:4718 path:hsa04714 Thermogenesis - Homo sapiens (human)
NDUFC2 hsa:4718 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
NDUFC2 hsa:4718 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
NDUFC2 hsa:4718 path:hsa05010 Alzheimer disease - Homo sapiens (human)
NDUFC2 hsa:4718 path:hsa05012 Parkinson disease - Homo sapiens (human)
NDUFC2 hsa:4718 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
NDUFC2 hsa:4718 path:hsa05016 Huntington disease - Homo sapiens (human)
NDUFC2 hsa:4718 path:hsa05020 Prion disease - Homo sapiens (human)
NDUFC2 hsa:4718 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
NDUFC2 hsa:4718 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
NDUFC2 hsa:4718 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MT-ND1 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND2 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND3 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4L NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND5 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND6 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA1 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA10 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA11 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA12 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA13 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA2 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA3 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA4 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA5 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA7 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA8 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA9 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFAB1 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB1 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB10 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB11 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB2 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB3 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB7 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB8 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB9 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFC1 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS1 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS3 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS4 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS5 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS6 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS7 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS8 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFV1 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFV2 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFV3 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
GZMA NDUFC2 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
NDUFAF2 NDUFC2 15526035 16200211 16218961 17344420 20025615 20816094 26192618 interaction type N/A ACSN
ACAD9 NDUFC2 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
ECSIT NDUFC2 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
NDUFAF1 NDUFC2 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
AIFM1 NDUFC2 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389 26192618 interaction type N/A ACSN
NDUFC2 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 NDUFC2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 NDUFC2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 NDUFC2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NDUFC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NDUFC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NDUFC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NDUFC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NDUFC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NDUFC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004E008F NDUFC2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B NDUFC2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000075D814 NDUFC2 23824327 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075CC78 NDUFC2 23824327 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000498DAA NDUFC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC NDUFC2 23824327 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000021202F NDUFC2 23824327 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NDUFA2 NDUFC2 25361965 interaction type N/A PTMCode2
NDUFC2 NDUFA2 25361965 interaction type N/A PTMCode2
NDUFAB1 NDUFC2 25361965 interaction type N/A PTMCode2
NDUFC2 NDUFAB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
YIPF3 NDUFC2 25348397 N/A physical interaction ComPPI
TIMMDC1 NDUFC2 25348397 N/A physical interaction ComPPI
NDUFAF4 NDUFC2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NIT1 NDUFC2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
ELAVL1 NDUFC2 25348397 N/A physical interaction ComPPI
ECSIT NDUFC2 25348397 N/A physical interaction ComPPI
NDUFS7 NDUFC2 25348397 N/A physical interaction ComPPI
WBP1 NDUFC2 25348397 N/A physical interaction ComPPI
NDUFA13 NDUFC2 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 NDUFC2 25348397 N/A physical interaction ComPPI
NDUFA6 NDUFC2 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TACR1 NDUFC2 25348397 N/A physical interaction ComPPI
COX6B1 NDUFC2 25348397 N/A physical interaction ComPPI
ACAD9 NDUFC2 25348397 N/A physical interaction ComPPI
NDUFA8 NDUFC2 25348397 N/A physical interaction ComPPI
DHRS4 NDUFC2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFA2 NDUFC2 19688755 24234451 25348397 physical association blue native page ComPPI,IntAct
NDUFB11 NDUFC2 25348397 N/A physical interaction ComPPI
NDUFC2 TMEM126B 25348397 N/A physical interaction ComPPI
NDUFC2 CISD3 25348397 N/A physical interaction ComPPI
NDUFC2 SPPL2B 25348397 N/A physical interaction ComPPI
NDUFC2 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFC2 IMPDH1 25348397 N/A physical interaction ComPPI
NDUFC2 LPAR6 25348397 N/A physical interaction ComPPI
NDUFC2 CSGALNACT2 25348397 N/A physical interaction ComPPI
NDUFC2 COA3 23260140 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFC2 OPA3 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFC2 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFC2 COQ10A 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
HSCB NDUFC2 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct

Visualization










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