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GENE：NDUFS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NDUFS2
FullNmae NADH:ubiquinone oxidoreductase core subunit S2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7708
EnsembleID ENSG00000158864
Uniprot O75306

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NDUFS2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NDUFS2 GO:0003954,GO:0005515,GO:0005654,GO:0005739,GO:0005739,GO:0005743,GO:0005747,GO:0005747,GO:0005747,GO:0005747,GO:0005747,GO:0005759,GO:0006120,GO:0006120,GO:0006120,GO:0006979,GO:0008137,GO:0008137,GO:0009055,GO:0009060,GO:0019826,GO:0022008,GO:0031625,GO:0032981,GO:0042063,GO:0042775,GO:0042776,GO:0046872,GO:0048038,GO:0051287,GO:0051539,GO:0061351,GO:0071453

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NDUFS2 hsa:4720 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
NDUFS2 hsa:4720 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NDUFS2 hsa:4720 path:hsa04714 Thermogenesis - Homo sapiens (human)
NDUFS2 hsa:4720 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
NDUFS2 hsa:4720 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
NDUFS2 hsa:4720 path:hsa05010 Alzheimer disease - Homo sapiens (human)
NDUFS2 hsa:4720 path:hsa05012 Parkinson disease - Homo sapiens (human)
NDUFS2 hsa:4720 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
NDUFS2 hsa:4720 path:hsa05016 Huntington disease - Homo sapiens (human)
NDUFS2 hsa:4720 path:hsa05020 Prion disease - Homo sapiens (human)
NDUFS2 hsa:4720 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
NDUFS2 hsa:4720 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
NDUFS2 hsa:4720 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MT-ND1 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND2 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND3 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4L NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND5 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND6 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA1 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA7 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB9 NDUFS2 12847084 15186778 15526035 15807660 16186509 16200211 16218961 17344420 18199748 18360008 18485875 19131594 19509052 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS1 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFA10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFA11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFA12 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFA13 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFA2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFA3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFA4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFA5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFA6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFA8 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFA9 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFAB1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFB1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFB11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFB2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFB3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFB7 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFB8 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFC1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFS3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFS4 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFS5 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFS7 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFV1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFV2 12847084 15186778 15526035 15807660 16186509 16200211 16218961 17344420 18485875 19131594 19509052 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFV3 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS8 NDUFS2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
GZMA NDUFS2 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
NDUFAF2 NDUFS2 15526035 16200211 16218961 17344420 20025615 20816094 26192618 interaction type N/A ACSN
ACAD9 NDUFS2 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
ECSIT NDUFS2 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
NDUFAF1 NDUFS2 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
AIFM1 NDUFS2 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389 26192618 interaction type N/A ACSN
SEL1L NDUFS2 12847084 15186778 15526035 15807660 16186509 16200211 16218961 17344420 18199748 18360008 18485875 19131594 19509052 20025615 20816094 26192618 interaction type N/A ACSN
SYVN1 NDUFS2 12847084 15186778 15526035 15807660 16186509 16200211 16218961 17344420 18199748 18360008 18485875 19131594 19509052 20025615 20816094 26192618 interaction type N/A ACSN
ADRB2 NDUFS2 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 NDUFS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 NDUFS2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 NDUFS2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NDUFS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NDUFS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NDUFS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 NDUFS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NDUFS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR NDUFS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000041FA2C NDUFS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000076B539 NDUFS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004F4657 NDUFS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD NDUFS2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 NDUFS2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NDUFA9 NDUFS2 25361965 interaction type N/A PTMCode2
NDUFS2 NDUFA9 25361965 interaction type N/A PTMCode2
NDUFA2 NDUFS2 25361965 interaction type N/A PTMCode2
NDUFS2 NDUFA2 25361965 interaction type N/A PTMCode2
NDUFS7 NDUFS2 25361965 interaction type N/A PTMCode2
NDUFS2 NDUFS7 25361965 interaction type N/A PTMCode2
MT-ND1 NDUFS2 25361965 interaction type N/A PTMCode2
NDUFS2 MT-ND1 25361965 interaction type N/A PTMCode2
NDUFAB1 NDUFS2 25361965 interaction type N/A PTMCode2
NDUFS2 NDUFAB1 25361965 interaction type N/A PTMCode2
NDUFS8 NDUFS2 25361965 interaction type N/A PTMCode2
NDUFS2 NDUFS8 25361965 interaction type N/A PTMCode2
NDUFV2 NDUFS2 25361965 interaction type N/A PTMCode2
NDUFS2 NDUFV2 25361965 interaction type N/A PTMCode2
MT-ND4 NDUFS2 25361965 interaction type N/A PTMCode2
NDUFS2 MT-ND4 25361965 interaction type N/A PTMCode2
MT-ND5 NDUFS2 25361965 interaction type N/A PTMCode2
NDUFS2 MT-ND5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NDUFAF3 NDUFS2 19688755 24234451 24344204 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,blue native page ComPPI,IntAct
KEAP1 NDUFS2 25348397 N/A physical interaction ComPPI
CPSF7 NDUFS2 25348397 N/A physical interaction ComPPI
TIMMDC1 NDUFS2 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFAF4 NDUFS2 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VAPA NDUFS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL3 NDUFS2 25348397 N/A physical interaction ComPPI
DLD NDUFS2 25348397 N/A physical interaction ComPPI
NTRK1 NDUFS2 25348397 N/A physical interaction ComPPI
NIT1 NDUFS2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PHB NDUFS2 15250827 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MYC NDUFS2 17314511 21150319 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SQSTM1 NDUFS2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ADRB2 NDUFS2 25348397 N/A physical interaction ComPPI
MMS19 NDUFS2 25348397 N/A physical interaction ComPPI
DLAT NDUFS2 25348397 N/A physical interaction ComPPI
PRKN NDUFS2 25348397 N/A physical interaction ComPPI
PDK1 NDUFS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ECSIT NDUFS2 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CENPU NDUFS2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFRSF14 NDUFS2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NDUFS7 NDUFS2 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AURKAIP1 NDUFS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FAF2 NDUFS2 25348397 N/A physical interaction ComPPI
AGO2 NDUFS2 25348397 N/A physical interaction ComPPI
SHMT2 NDUFS2 25348397 N/A physical interaction ComPPI
NDUFA13 NDUFS2 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPD1 NDUFS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HMOX2 NDUFS2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
OGDH NDUFS2 25348397 N/A physical interaction ComPPI
KCND3 NDUFS2 25348397 N/A physical interaction ComPPI
NDUFV2 NDUFS2 15250827 24234451 24344204 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EGR2 NDUFS2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NDUFV1 NDUFS2 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POU5F1 NDUFS2 25348397 N/A physical interaction ComPPI
AIFM1 NDUFS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 NDUFS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFS6 NDUFS2 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MGST3 NDUFS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MTRES1 NDUFS2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFA6 NDUFS2 12611891 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
COQ9 NDUFS2 25348397 N/A physical interaction ComPPI
DMWD NDUFS2 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FBXO6 NDUFS2 25348397 N/A physical interaction ComPPI
MTCH2 NDUFS2 25348397 N/A physical interaction ComPPI
NDUFS1 NDUFS2 25348397 N/A physical interaction ComPPI
APP NDUFS2 25348397 N/A physical interaction ComPPI
NXF1 NDUFS2 25348397 N/A physical interaction ComPPI
MKLN1 NDUFS2 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
NDUFA9 NDUFS2 15250827 24234451 24344204 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,blue native page ComPPI,IntAct
MOV10 NDUFS2 25348397 N/A physical interaction ComPPI
ATP5PB NDUFS2 25348397 N/A physical interaction ComPPI
SFXN1 NDUFS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX6B1 NDUFS2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFA10 NDUFS2 25348397 N/A physical interaction ComPPI
NDUFS2 MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS2 NDUFS3 15250827 19688755 24234451 24344204 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,blue native page ComPPI,IntAct
NDUFS2 NDUFS8 25348397 N/A physical interaction ComPPI
NDUFS2 SDHA 25348397 N/A physical interaction ComPPI
NDUFS2 MRPS21 25348397 N/A physical interaction ComPPI
NDUFS2 HSPA1L 25348397 N/A physical interaction ComPPI
NDUFS2 NDUFA8 25348397 N/A physical interaction ComPPI
NDUFS2 LMAN2 25348397 N/A physical interaction ComPPI
NDUFS2 SDHC 25348397 N/A physical interaction ComPPI
NDUFS2 TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NDUFS2 ACAD9 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS2 NDUFA12 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS2 NDUFS4 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS2 NDUFS5 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS2 NDUFA11 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS2 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS2 NDUFA4 25348397 N/A physical interaction ComPPI
NDUFS2 DHRS4 25348397 N/A physical interaction ComPPI
NDUFS2 NMES1 25348397 N/A physical interaction ComPPI
NDUFS2 CISD3 25348397 N/A physical interaction ComPPI
NDUFS2 MAIP1 25348397 N/A physical interaction ComPPI
NDUFS2 OCIAD1 25348397 N/A physical interaction ComPPI
NDUFS2 NDUFB11 25348397 N/A physical interaction ComPPI
NDUFS2 NDUFA2 19688755 24234451 25348397 physical association blue native page ComPPI,IntAct
NDUFS2 SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFS2 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFS2 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFS2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFS2 NDUFAF5 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFS2 ECI2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFS2 COQ10A 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFS2 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFS2 OPA3 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
TRMT61B NDUFS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HSCB NDUFS2 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct

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