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GENE：NDUFS6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NDUFS6
FullNmae NADH:ubiquinone oxidoreductase subunit S6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7713
EnsembleID ENSG00000145494
Uniprot O75380

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NDUFS6 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NDUFS6 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NDUFS6 GO:0005743,GO:0005743,GO:0005747,GO:0005747,GO:0005747,GO:0005747,GO:0006120,GO:0006120,GO:0008137,GO:0009055,GO:0009060,GO:0042776

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NDUFS6 hsa:4726 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
NDUFS6 hsa:4726 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NDUFS6 hsa:4726 path:hsa04714 Thermogenesis - Homo sapiens (human)
NDUFS6 hsa:4726 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
NDUFS6 hsa:4726 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
NDUFS6 hsa:4726 path:hsa05010 Alzheimer disease - Homo sapiens (human)
NDUFS6 hsa:4726 path:hsa05012 Parkinson disease - Homo sapiens (human)
NDUFS6 hsa:4726 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
NDUFS6 hsa:4726 path:hsa05016 Huntington disease - Homo sapiens (human)
NDUFS6 hsa:4726 path:hsa05020 Prion disease - Homo sapiens (human)
NDUFS6 hsa:4726 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
NDUFS6 hsa:4726 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
NDUFS6 hsa:4726 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MT-ND1 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND2 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND3 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND4L NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND5 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
MT-ND6 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA1 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA12 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA2 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA3 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA4 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA5 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA6 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA7 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFA8 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB1 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB2 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB3 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB4 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB5 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB6 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB8 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFB9 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFC1 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS1 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS2 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS3 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS4 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS5 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS6 NDUFA10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS6 NDUFA11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS6 NDUFA13 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS6 NDUFA9 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS6 NDUFAB1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS6 NDUFB10 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS6 NDUFB11 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS6 NDUFB7 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS6 NDUFC2 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS6 NDUFV1 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS7 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFS8 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFV2 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
NDUFV3 NDUFS6 15186778 15526035 15807660 16200211 16218961 17344420 18485875 19131594 20025615 20816094 26192618 interaction type N/A ACSN
GZMA NDUFS6 11413196 14499263 15607806 16106370 18485875 26192618 8432729 interaction type N/A ACSN
NDUFAF2 NDUFS6 15526035 16200211 16218961 17344420 20025615 20816094 26192618 interaction type N/A ACSN
ACAD9 NDUFS6 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
ECSIT NDUFS6 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
NDUFAF1 NDUFS6 10465784 15526035 16200211 16218961 17344420 20025615 20816094 25371197 26192618 26989860 interaction type N/A ACSN
AIFM1 NDUFS6 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR NDUFS6 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 NDUFS6 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 NDUFS6 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 NDUFS6 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CTCF NDUFS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NDUFS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NDUFS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NDUFS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NDUFS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NDUFS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NDUFS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 NDUFS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC NDUFS6 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 NDUFS6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000330617 NDUFS6 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
NDUFA2 NDUFS6 25361965 interaction type N/A PTMCode2
NDUFS6 NDUFA2 25361965 interaction type N/A PTMCode2
NDUFAB1 NDUFS6 25361965 interaction type N/A PTMCode2
NDUFS6 NDUFAB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NDUFB9 NDUFS6 25348397 N/A physical interaction ComPPI
FBXO17 NDUFS6 25348397 N/A physical interaction ComPPI
MRM3 NDUFS6 25348397 N/A physical interaction ComPPI
ZMYND19 NDUFS6 25348397 N/A physical interaction ComPPI
NDUFAF4 NDUFS6 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
VAPA NDUFS6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB7A NDUFS6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NIT1 NDUFS6 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
RALA NDUFS6 25348397 N/A physical interaction ComPPI
MAPK6 NDUFS6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDHA1 NDUFS6 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MAPK8IP2 NDUFS6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RMND5A NDUFS6 25348397 N/A physical interaction ComPPI
MT-ND1 NDUFS6 25348397 N/A physical interaction ComPPI
NEDD8 NDUFS6 25348397 N/A physical interaction ComPPI
VAPB NDUFS6 25348397 N/A physical interaction ComPPI
FGFR3 NDUFS6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
LIG3 NDUFS6 25348397 N/A physical interaction ComPPI
MAP3K7 NDUFS6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RANBP10 NDUFS6 25348397 N/A physical interaction ComPPI
PDK1 NDUFS6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SARS2 NDUFS6 25348397 N/A physical interaction ComPPI
GDNF NDUFS6 24234451 25348397 25416956 physical association anti tag coimmunoprecipitation ComPPI,IntAct
KCNH2 NDUFS6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NDUFS7 NDUFS6 25348397 N/A physical interaction ComPPI
ILKAP NDUFS6 25348397 N/A physical interaction ComPPI
DTX3 NDUFS6 25348397 N/A physical interaction ComPPI
AURKAIP1 NDUFS6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GALNT6 NDUFS6 25348397 N/A physical interaction ComPPI
FLOT1 NDUFS6 25348397 N/A physical interaction ComPPI
MT-ND4 NDUFS6 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFA13 NDUFS6 25348397 N/A physical interaction ComPPI
DNAJC30 NDUFS6 25348397 N/A physical interaction ComPPI
HSPD1 NDUFS6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ILF3 NDUFS6 25348397 N/A physical interaction ComPPI
NDUFV2 NDUFS6 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFV1 NDUFS6 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFB1 NDUFS6 25348397 N/A physical interaction ComPPI
AIFM1 NDUFS6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 NDUFS6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SEPTIN11 NDUFS6 25348397 N/A physical interaction ComPPI
NDUFB3 NDUFS6 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFA2 19688755 24234451 25348397 physical association physical interaction,blue native page ComPPI,IntAct
NDUFS6 NDUFS4 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFB4 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFS2 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 NDUFS8 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 TJP1 25348397 N/A physical interaction ComPPI
NDUFS6 NNT 25348397 N/A physical interaction ComPPI
NDUFS6 TMEM65 25348397 N/A physical interaction ComPPI
NDUFS6 SDHA 25348397 N/A physical interaction ComPPI
NDUFS6 RPS12 25348397 N/A physical interaction ComPPI
NDUFS6 COX15 25348397 N/A physical interaction ComPPI
NDUFS6 MPV17 25348397 N/A physical interaction ComPPI
NDUFS6 MOV10 25348397 N/A physical interaction ComPPI
NDUFS6 NXF1 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFS3 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 ECHDC2 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFA8 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFA12 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 NDUFS5 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 NDUFA9 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 NDUFA11 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 NDUFV3 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 NDUFS1 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 NDUFA7 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 MMGT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 BOLA3 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFA4 25348397 N/A physical interaction ComPPI
NDUFS6 NMES1 25348397 N/A physical interaction ComPPI
NDUFS6 COX6B1 25348397 N/A physical interaction ComPPI
NDUFS6 FAM136A 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFB7 25348397 N/A physical interaction ComPPI
NDUFS6 MT-ND5 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFB6 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFC2 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFB8 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFB5 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFB11 25348397 N/A physical interaction ComPPI
NDUFS6 FAHD1 25348397 N/A physical interaction ComPPI
NDUFS6 MT-ND2 25348397 N/A physical interaction ComPPI
NDUFS6 TACR1 25348397 N/A physical interaction ComPPI
NDUFS6 ALAS1 25348397 N/A physical interaction ComPPI
NDUFS6 ARMC8 25348397 N/A physical interaction ComPPI
NDUFS6 GID4 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFA6 12611891 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFS6 GDPD5 25348397 N/A physical interaction ComPPI
NDUFS6 GID8 25348397 N/A physical interaction ComPPI
NDUFS6 METTL2A 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFA1 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFA3 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFB10 25348397 N/A physical interaction ComPPI
NDUFS6 NDUFAB1 25348397 N/A physical interaction ComPPI
NDUFS6 TRMT1 25348397 N/A physical interaction ComPPI
NDUFS6 PCK2 25348397 N/A physical interaction ComPPI
NDUFS6 RASL10B 25348397 N/A physical interaction ComPPI
NDUFS6 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFS6 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFS6 SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFS6 DHRS4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFS6 DGLUCY 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFS6 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
MGST3 NDUFS6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BCAT2 NDUFS6 25348397 N/A physical interaction ComPPI
TRMT61B NDUFS6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GCAT NDUFS6 25348397 N/A physical interaction ComPPI
FGL1 NDUFS6 25348397 N/A physical interaction ComPPI
HSCB NDUFS6 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct

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