GENE：NFS1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NFS1 |
| FullNmae | NFS1 cysteine desulfurase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:15910 |
| EnsembleID | ENSG00000244005 |
| Uniprot | Q9Y697 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NFS1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NFS1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NFS1 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| NFS1 | cuproptosis | 36313717 | Proteins carrying iron-sulfur clusters are essential for the basic metabolism of all organisms. Eukaryotic iron-sulfur cluster assembly includes direct mitochondrial iron-sulfur cluster (ISC) co-assembly pathway and cytosolic iron-sulfur cluster assembly (CIA) pathway that uses active sulfur as substrate, these pathways containing protein complex (composed of cysteine desulfurase, a scaffold protein, auxiliary ISD11 protein, acyl carrier protein, frataxin, and ferredoxin), the related genes (including NFS1, ISD11, ACP1, ISCU2, FXN, FDX2, FDXR) and proteins of cytokine induced apoptosis inhibitor 1 (CIAPIN1), novel diflavin oxidoreductase 1 (NDOR1), nucleotide binding protein 2 (NUBP2), nucleotide binding protein 1 (NUBP1), iron-only hydrogenase-like protein 1 (IOP1), and Cytosolic iron-Sulfur assembly component 1 (CIAO1) | Proteins carrying iron-sulfur cluster |
| NFS1 | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. | Genes of iron-sulfur cluster related proteins |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NFS1 | GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005739,GO:0005739,GO:0005759,GO:0005759,GO:0005813,GO:0005829,GO:0005829,GO:0005829,GO:0006777,GO:0016226,GO:0016226,GO:0016226,GO:0018283,GO:0030170,GO:0031071,GO:0031071,GO:0031071,GO:0042803,GO:0044571,GO:0044572,GO:0046872,GO:0051536,GO:0099128,GO:1990229 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NFS1 | hsa:9054 | path:hsa00730 | Thiamine metabolism - Homo sapiens (human) |
| NFS1 | hsa:9054 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| NFS1 | hsa:9054 | path:hsa01240 | Biosynthesis of cofactors - Homo sapiens (human) |
| NFS1 | hsa:9054 | path:hsa04122 | Sulfur relay system - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | NFS1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| HIF1A | NFS1 | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOXP3 | NFS1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | NFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | NFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | NFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NFS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000153377 | NFS1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00004959F4 | NFS1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000025EABA | NFS1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B0E50 | NFS1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HSPA8 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| GPX7 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R1A | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| PCGF2 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| PAK5 | NFS1 | 24234451 25348397 27499296 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| TACC3 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| PICK1 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| GRB2 | NFS1 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| OXT | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| DYNC1LI1 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| DLD | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| CTR9 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| FYN | NFS1 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| HDAC5 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| BCOR | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| PDK1 | NFS1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| IKZF1 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| RB1CC1 | NFS1 | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| CLPP | NFS1 | 24234451 25348397 26058080 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| SOD1 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| ZWINT | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| HSPD1 | NFS1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| PSMC2 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| ABL1 | NFS1 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| COX6B1 | NFS1 | 24234451 25348397 27499296 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| ISCU | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| ACAD9 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| KLHL22 | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| TRMT61B | NFS1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| MRRF | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| NFS1 | NDUFAB1 | 25348397 | N/A | physical interaction | ComPPI |
| NFS1 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| NFS1 | NDUFA4 | 25348397 | N/A | physical interaction | ComPPI |