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GENE：NFYC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NFYC
FullNmae nuclear transcription factor Y subunit gamma
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7806
EnsembleID ENSG00000066136
Uniprot Q13952

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NFYC immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NFYC cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NFYC GO:0000785,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0006355,GO:0006357,GO:0006457,GO:0016602,GO:0016602,GO:0016602,GO:0032993,GO:0035065,GO:0045944,GO:0046982,GO:0090575

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NFYC hsa:4802 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
NFYC hsa:4802 path:hsa05152 Tuberculosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CFTR NFYC 10075672 23180781 physical association electrophoretic mobility supershift assay InnateDB
MZF1 NFYC 16982898 23180781 physical association anti tag coimmunoprecipitation InnateDB
MS4A2 NFYC 16982898 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFYC COL11A1 12805369 23180781 physical association electrophoretic mobility supershift assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR NFYC 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 NFYC 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 NFYC 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NFYC 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 NFYC 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NFYC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYB NFYC N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000CBE63 NFYC 23547260 rna interference,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay miRSponge
URS00000CBE63 NFYC 23547260 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS0000338542 NFYC 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000170CF4 NFYC 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
LMO4 NFYC 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NFYB NFYC 12401788 20936779 21988832 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,x-ray crystallography,physical interaction,two hybrid pooling approach,in vitro ComPPI,IntAct
TAF12 NFYC 25348397 N/A physical interaction ComPPI
PRR20E NFYC 25348397 N/A physical interaction ComPPI
PRR20C NFYC 25348397 N/A physical interaction ComPPI
PRR20D NFYC 25348397 N/A physical interaction ComPPI
DR1 NFYC 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SP1 NFYC 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TBP NFYC 25348397 N/A physical interaction ComPPI
NFYA NFYC 15243141 20936779 23332751 24234451 25348397 association,physical association coimmunoprecipitation,x-ray crystallography,physical interaction,two hybrid pooling approach,biochemical,in vitro ComPPI,IntAct
SMAD2 NFYC 25348397 N/A physical interaction,in vivo ComPPI
SMAD3 NFYC 25348397 N/A physical interaction,in vivo ComPPI
KAT2B NFYC 25348397 N/A physical interaction ComPPI
PON1 NFYC 25348397 N/A physical interaction ComPPI
GAPDH NFYC 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNX2 NFYC 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MYC NFYC 25348397 N/A physical interaction,in vitro,in vivo ComPPI
SREBF2 NFYC 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TP73 NFYC 25348397 N/A physical interaction ComPPI
NFATC2 NFYC 25348397 N/A physical interaction ComPPI
TAF11 NFYC 25348397 N/A physical interaction ComPPI
CDK2 NFYC 25348397 N/A physical interaction ComPPI
ZDHHC17 NFYC 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NFYC ATF6B 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
NFYC ATF6 20936779 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro ComPPI,IntAct
NFYC DST 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NFYC ADNP2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NFYC POGZ 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NFYC CIC 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NFYC BICRAL 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NFYC BICRA 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NFYC ARID2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NFYC USF3 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NFYC TRIM27 25348397 N/A physical interaction ComPPI
NFYC TBPL2 25348397 N/A physical interaction ComPPI
NFYC HDAC1 25348397 N/A physical interaction ComPPI
NFYC TAF6 25348397 N/A physical interaction ComPPI
NFYC ELAVL1 25348397 N/A physical interaction ComPPI
NFYC FCGR2A 25348397 N/A physical interaction ComPPI
NFYC CORO1B 25348397 N/A physical interaction ComPPI
NFYC CORO1C 25348397 N/A physical interaction ComPPI
NFYC FOXJ2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
NFYC FOXK2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
NFYC ENDOG 25348397 N/A physical interaction ComPPI
NFYC PON3 25348397 N/A physical interaction ComPPI
NFYC NFKB1 25348397 N/A physical interaction ComPPI
NFYC COMMD1 25348397 N/A physical interaction ComPPI
CSN2 NFYC 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
RNF4 NFYC 15496512 27898060 stimulant N/A OmniPath

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