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GENE：NOP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NOP2
FullNmae NOP2 nucleolar protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7867
EnsembleID ENSG00000111641
Uniprot P46087

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NOP2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NOP2 GO:0000027,GO:0000470,GO:0003723,GO:0005515,GO:0005654,GO:0005730,GO:0005730,GO:0005730,GO:0008284,GO:0009383,GO:0070475,GO:1901796

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EIF2AK2 NOP2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
EZH2 NOP2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 NOP2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
EED NOP2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 NOP2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR NOP2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 NOP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 NOP2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NOP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NOP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NOP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 NOP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NOP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 NOP2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000FC8EB NOP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002971AB NOP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000033EBB8 NOP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE NOP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C3AC1 NOP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 NOP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC NOP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000148B91 NOP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000CF1D2 NOP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 NOP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B NOP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000171CD1 NOP2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
BMS1 NOP2 25361965 interaction type N/A PTMCode2
NOP2 BMS1 25361965 interaction type N/A PTMCode2
GAR1 NOP2 25361965 interaction type N/A PTMCode2
NOP2 GAR1 25361965 interaction type N/A PTMCode2
EIF6 NOP2 25361965 interaction type N/A PTMCode2
NOP2 EIF6 25361965 interaction type N/A PTMCode2
PES1 NOP2 25361965 interaction type N/A PTMCode2
NOP2 PES1 25361965 interaction type N/A PTMCode2
GTPBP4 NOP2 25361965 interaction type N/A PTMCode2
NOP2 GTPBP4 25361965 interaction type N/A PTMCode2
NPM1 NOP2 25361965 interaction type N/A PTMCode2
NOP2 NPM1 25361965 interaction type N/A PTMCode2
FBL NOP2 25361965 interaction type N/A PTMCode2
NOP2 FBL 25361965 interaction type N/A PTMCode2
NOP58 NOP2 25361965 interaction type N/A PTMCode2
NOP2 NOP58 25361965 interaction type N/A PTMCode2
MRTO4 NOP2 25361965 interaction type N/A PTMCode2
NOP2 MRTO4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I NOP2 25348397 N/A physical interaction ComPPI
CDC5L NOP2 25348397 N/A physical interaction ComPPI
THAP7 NOP2 25348397 N/A physical interaction ComPPI
CBX8 NOP2 21282530 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DDX21 NOP2 25348397 N/A physical interaction ComPPI
RPS7 NOP2 25348397 N/A physical interaction ComPPI
NPM1 NOP2 14525934 25348397 27898060 8089149 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
RPL37A NOP2 25348397 N/A physical interaction ComPPI
LMNA NOP2 25348397 N/A physical interaction ComPPI
MCM5 NOP2 25348397 N/A physical interaction ComPPI
GABARAPL2 NOP2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RPL11 NOP2 25348397 N/A physical interaction ComPPI
NOL12 NOP2 25348397 N/A physical interaction ComPPI
KEAP1 NOP2 25348397 N/A physical interaction ComPPI
NIFK NOP2 25348397 N/A physical interaction ComPPI
RRS1 NOP2 25348397 N/A physical interaction ComPPI
RPL10A NOP2 25348397 N/A physical interaction ComPPI
EZH2 NOP2 25348397 N/A physical interaction ComPPI
RPL10 NOP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN NOP2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
MYBBP1A NOP2 25348397 N/A physical interaction ComPPI
COPS5 NOP2 25348397 N/A physical interaction ComPPI
RPL18A NOP2 25348397 N/A physical interaction ComPPI
CPNE4 NOP2 25348397 N/A physical interaction ComPPI
RBM4 NOP2 25348397 N/A physical interaction ComPPI
PAXIP1 NOP2 25348397 N/A physical interaction ComPPI
CUL3 NOP2 25348397 N/A physical interaction ComPPI
MAP4K4 NOP2 25348397 N/A physical interaction ComPPI
NTRK1 NOP2 25348397 N/A physical interaction ComPPI
EIF2AK2 NOP2 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BAG6 NOP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPU NOP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF6 NOP2 25348397 N/A physical interaction ComPPI
RPS6 NOP2 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RPL4 NOP2 25348397 N/A physical interaction ComPPI
SUMO2 NOP2 25348397 N/A physical interaction ComPPI
SRPK1 NOP2 25348397 N/A physical interaction ComPPI
CSNK2A2 NOP2 25348397 N/A physical interaction ComPPI
MPHOSPH8 NOP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 NOP2 25348397 N/A physical interaction ComPPI
CUL1 NOP2 25348397 N/A physical interaction ComPPI
H1-4 NOP2 25348397 N/A physical interaction ComPPI
SYNCRIP NOP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MCRS1 NOP2 14525934 25348397 9654073 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
RNF2 NOP2 25348397 N/A physical interaction ComPPI
CEBPZ NOP2 25348397 N/A physical interaction ComPPI
MTREX NOP2 25348397 N/A physical interaction ComPPI
NOLC1 NOP2 25348397 N/A physical interaction ComPPI
NCSTN NOP2 25348397 N/A physical interaction ComPPI
GABARAP NOP2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
GNL3 NOP2 25348397 N/A physical interaction ComPPI
EED NOP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UTP14A NOP2 25348397 N/A physical interaction ComPPI
RPL7 NOP2 25348397 N/A physical interaction ComPPI
MECP2 NOP2 25348397 N/A physical interaction ComPPI
CUL7 NOP2 25348397 N/A physical interaction ComPPI
H3C1 NOP2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HDAC5 NOP2 25348397 N/A physical interaction ComPPI
HDAC11 NOP2 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAND1 NOP2 25348397 N/A physical interaction ComPPI
SART3 NOP2 25348397 N/A physical interaction ComPPI
SRSF3 NOP2 25348397 N/A physical interaction ComPPI
HDAC9 NOP2 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPL5 NOP2 25348397 N/A physical interaction ComPPI
MINK1 NOP2 25348397 N/A physical interaction ComPPI
SSRP1 NOP2 25348397 N/A physical interaction ComPPI
NOP56 NOP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRPK2 NOP2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ILF2 NOP2 25348397 N/A physical interaction ComPPI
ESR1 NOP2 21182205 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
KPNA6 NOP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BRCA1 NOP2 25348397 N/A physical interaction ComPPI
RPL6 NOP2 25348397 N/A physical interaction ComPPI
RPL23A NOP2 25348397 N/A physical interaction ComPPI
RPL23 NOP2 25348397 N/A physical interaction ComPPI
SORT1 NOP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ALYREF NOP2 25348397 N/A physical interaction ComPPI
CEP250 NOP2 25348397 N/A physical interaction ComPPI
TOP1 NOP2 15848144 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TOP2A NOP2 25348397 N/A physical interaction ComPPI
TARDBP NOP2 25348397 N/A physical interaction ComPPI
RPL14 NOP2 25348397 N/A physical interaction ComPPI
BOP1 NOP2 25348397 N/A physical interaction ComPPI
PES1 NOP2 25348397 N/A physical interaction ComPPI
RRP1B NOP2 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SRPK3 NOP2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SUZ12 NOP2 25348397 N/A physical interaction ComPPI
DGCR8 NOP2 25348397 N/A physical interaction ComPPI
MPHOSPH10 NOP2 25348397 N/A physical interaction ComPPI
NIP7 NOP2 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
DDX56 NOP2 25348397 N/A physical interaction ComPPI
MED4 NOP2 25348397 N/A physical interaction ComPPI
MCM7 NOP2 23764002 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
HDGF NOP2 21907836 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MT1F NOP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RPS2 NOP2 25348397 N/A physical interaction ComPPI
CYLD NOP2 25348397 N/A physical interaction ComPPI
RPS15A NOP2 25348397 N/A physical interaction ComPPI
KRR1 NOP2 25348397 N/A physical interaction ComPPI
RPL8 NOP2 25348397 N/A physical interaction ComPPI
DKC1 NOP2 25348397 N/A physical interaction ComPPI
FTSJ3 NOP2 25348397 N/A physical interaction ComPPI
MTF1 NOP2 25348397 N/A physical interaction ComPPI
CEP70 NOP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DDX24 NOP2 25348397 N/A physical interaction ComPPI
NOC2L NOP2 25348397 N/A physical interaction ComPPI
FBL NOP2 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RPL30 NOP2 25348397 N/A physical interaction ComPPI
GTPBP4 NOP2 25348397 N/A physical interaction ComPPI
MNDA NOP2 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
NFIA NOP2 25348397 N/A physical interaction ComPPI
BRIX1 NOP2 25348397 N/A physical interaction ComPPI
RPS4X NOP2 25348397 N/A physical interaction ComPPI
SIRT7 NOP2 25348397 N/A physical interaction ComPPI
NOP53 NOP2 25348397 N/A physical interaction ComPPI
DDX18 NOP2 25348397 N/A physical interaction ComPPI
PUM3 NOP2 25348397 N/A physical interaction ComPPI
RPL15 NOP2 25348397 N/A physical interaction ComPPI
VPS52 NOP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PRPF8 NOP2 25348397 N/A physical interaction ComPPI
CNBP NOP2 25348397 N/A physical interaction ComPPI
MAP3K1 NOP2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NOP2 RPL19 25348397 N/A physical interaction ComPPI
NOP2 RPL18 25348397 N/A physical interaction ComPPI
NOP2 RPS8 25348397 N/A physical interaction ComPPI
NOP2 NOP58 25348397 N/A physical interaction ComPPI
NOP2 RSL1D1 25348397 N/A physical interaction ComPPI
NOP2 RPS5 25348397 N/A physical interaction ComPPI
NOP2 HP1BP3 25348397 N/A physical interaction ComPPI
NOP2 LGR4 25348397 N/A physical interaction ComPPI
NOP2 LIN28A 25348397 N/A physical interaction ComPPI
NOP2 CDCA7L 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NOP2 MOV10 25348397 N/A physical interaction ComPPI
NOP2 OBSL1 25348397 N/A physical interaction ComPPI
NOP2 CCDC8 25348397 N/A physical interaction ComPPI
NOP2 DHX8 25348397 N/A physical interaction ComPPI
NOP2 ZC3H3 25348397 N/A physical interaction ComPPI
NOP2 PRR11 25348397 N/A physical interaction ComPPI
NOP2 DDX47 25348397 N/A physical interaction ComPPI
NOP2 NOC3L 25348397 N/A physical interaction ComPPI
NOP2 NOL6 25348397 N/A physical interaction ComPPI
NOP2 MRTO4 25348397 N/A physical interaction ComPPI
NOP2 NAT10 25348397 N/A physical interaction ComPPI
NOP2 RBM28 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
NOP2 NSA2 25348397 N/A physical interaction ComPPI
NOP2 RPF2 25348397 N/A physical interaction ComPPI
NOP2 CC2D2A 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NOP2 ZNF746 25348397 N/A physical interaction ComPPI
NOP2 ZC3HAV1 25348397 N/A physical interaction ComPPI
NOP2 RBM34 25348397 N/A physical interaction ComPPI
NOP2 MACROH2A2 25348397 N/A physical interaction ComPPI
NOP2 WDR46 25348397 N/A physical interaction ComPPI
NOP2 MAK16 25348397 N/A physical interaction ComPPI
NOP2 KNOP1 25348397 N/A physical interaction ComPPI
NOP2 SRP68 25348397 N/A physical interaction ComPPI
NOP2 MAGEB10 25348397 N/A physical interaction ComPPI
NOP2 ZNF512 25348397 N/A physical interaction ComPPI
NOP2 ZC3H18 24234451 25348397 29298432 association anti tag coimmunoprecipitation ComPPI,IntAct
EBNA1BP2 NOP2 25348397 N/A physical interaction ComPPI
DUX4 NOP2 24234451 25348397 26816005 association pull down ComPPI,IntAct
PTPRJ NOP2 12370829 14525934 9115287 N/A experimental interaction detection HPRD
METTL14 NOP2 24234451 29507755 association anti tag coimmunoprecipitation IntAct
H1-5 NOP2 24234451 30021884 physical association cross-linking study IntAct
H1-2 NOP2 24234451 30021884 physical association cross-linking study IntAct
H3-4 NOP2 24234451 30021884 physical association cross-linking study IntAct
H2BC9 NOP2 24234451 30021884 physical association cross-linking study IntAct
H2BC21 NOP2 24234451 30021884 physical association cross-linking study IntAct
H3C15 NOP2 24234451 30021884 physical association cross-linking study IntAct
NOP2 NBEAL2 24234451 30021884 physical association cross-linking study IntAct
NOP2 CENPK 24234451 30021884 physical association cross-linking study IntAct
NOP2 ZNF84 24234451 30021884 physical association cross-linking study IntAct
NOP2 PCNX1 24234451 30021884 physical association cross-linking study IntAct

Visualization










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