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GENE：NRF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NRF1
FullNmae nuclear respiratory factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7996
EnsembleID ENSG00000106459
Uniprot Q16656

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NRF1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NRF1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NRF1 GO:0000978,GO:0000978,GO:0000978,GO:0000981,GO:0001228,GO:0001228,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005829,GO:0006357,GO:0042803,GO:0045944,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NRF1 hsa:4899 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
NRF1 hsa:4899 path:hsa05016 Huntington disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NRF1 CXCR4 20068066 23180781 9379028 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 NRF1 18048642 21486948 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ESR2 NRF1 18048642 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 NRF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 NRF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NRF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 NRF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 NRF1 20587593 trascriptional regulation,stimulation inferred by curator TFlink
MEF2A NRF1 18222924 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 NRF1 20587593 trascriptional regulation,stimulation inferred by curator TFlink
RELA NRF1 20587593 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003CF1AD NRF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000411752 NRF1 20371350 22012620 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000170D8B NRF1 20371350 22012620 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C5969 NRF1 20371350 22012620 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007F792 NRF1 20371350 22012620 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000427B68 NRF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D NRF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A NRF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB NRF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 NRF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 NRF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D NRF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB NRF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 NRF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005F1B8C NRF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB0E NRF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AB32B NRF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA NRF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000019D79B NRF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000364FEF NRF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001799A3 NRF1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000472A9B NRF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 NRF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F NRF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002CAE0C NRF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 NRF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA NRF1 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075C3F6 NRF1 22012620 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AF45F NRF1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000CBE63 NRF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000568FF8 NRF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000345DEB NRF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 NRF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000004203C NRF1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C NRF1 25416803 26201446 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
NRF1 PPRC1 25361965 interaction type N/A PTMCode2
PPRC1 NRF1 25361965 interaction type N/A PTMCode2
NRF1 MAFF 25361965 interaction type N/A PTMCode2
MAFF NRF1 25361965 interaction type N/A PTMCode2
NRF1 NFE2L2 25361965 interaction type N/A PTMCode2
NFE2L2 NRF1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DYNLL1 NRF1 11069771 14525934 24234451 25348397 27173435 27898060 association,physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification,inference by socio-affinity scoring,two hybrid ComPPI,HPRD,IntAct,OmniPath
DYNLL2 NRF1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
CCND1 NRF1 16864783 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
SP4 NRF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FHL2 NRF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CEBPB NRF1 25348397 N/A physical interaction ComPPI
MAFF NRF1 12490281 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PPARGC1A NRF1 10412986 11943463 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PARP1 NRF1 25348397 N/A physical interaction ComPPI
CSNK2A1 NRF1 23816881 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HNRNPL NRF1 25348397 N/A physical interaction ComPPI
TRAF2 NRF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
POGZ NRF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NRF1 PPRC1 11340167 11943463 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
NRF1 CSNK2B 25348397 N/A physical interaction ComPPI
NRF1 PLXDC1 25348397 N/A physical interaction ComPPI
NRF1 FOXJ2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
NRF1 FOXK2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
NRF1 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
NRF1 WDR59 25348397 N/A physical interaction ComPPI
NRF1 SIRT7 24234451 25348397 25792330 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKI67 NRF1 24234451 26949251 association anti tag coimmunoprecipitation IntAct
NRF1 EIF2S1 16230352 27898060 stimulant N/A OmniPath
JUND NRF1 27898060 9872330 N/A N/A OmniPath
AKT1 NRF1 16230352 27898060 stimulant N/A OmniPath
NRF1 TFAM 16230352 27898060 stimulant N/A OmniPath
JUNB NRF1 27898060 9872330 N/A N/A OmniPath
NRF1 EIF2S2 16230352 27898060 stimulant N/A OmniPath
JUN NRF1 27898060 9872330 N/A N/A OmniPath

Visualization










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