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GENE：NSF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NSF
FullNmae N-ethylmaleimide sensitive factor, vesicle fusing ATPase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8016
EnsembleID ENSG00000073969
Uniprot P46459

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NSF cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
NSF GO:0000149,GO:0001921,GO:0005515,GO:0005524,GO:0005765,GO:0005794,GO:0005795,GO:0005795,GO:0005829,GO:0005829,GO:0005886,GO:0006813,GO:0006886,GO:0006887,GO:0006891,GO:0014069,GO:0016192,GO:0016887,GO:0016887,GO:0017075,GO:0017157,GO:0019901,GO:0030165,GO:0035255,GO:0035494,GO:0043001,GO:0043198,GO:0044877,GO:0044877,GO:0045026,GO:0045732,GO:0046872,GO:0140545

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NSF hsa:4905 path:hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
NSF hsa:4905 path:hsa04727 GABAergic synapse - Homo sapiens (human)
NSF hsa:4905 path:hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP NSF 16049941 23180781 physical association anti tag coimmunoprecipitation InnateDB
ADRB2 NSF 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
FOXP3 NSF 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F1 NSF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NSF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NSF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NSF 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 NSF 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 NSF 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 NSF 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D NSF 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 NSF 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B NSF 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002FC5B0 NSF 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 NSF 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000016914 NSF 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
LRRK2 NSF 22135298 phosphorylation N/A PhosphoSite
FES NSF 22135298 phosphorylation N/A PhosphoSite
FER NSF 22135298 phosphorylation N/A PhosphoSite
STX1A NSF 25361965 interaction type N/A PTMCode2
NSF STX1A 25361965 interaction type N/A PTMCode2
NAPG NSF 25361965 interaction type N/A PTMCode2
NSF NAPG 25361965 interaction type N/A PTMCode2
STX5 NSF 25361965 interaction type N/A PTMCode2
NSF STX5 25361965 interaction type N/A PTMCode2
NAPA NSF 25361965 interaction type N/A PTMCode2
NSF NAPA 25361965 interaction type N/A PTMCode2
GRIA1 NSF 25361965 interaction type N/A PTMCode2
NSF GRIA1 25361965 interaction type N/A PTMCode2
STX4 NSF 25361965 interaction type N/A PTMCode2
NSF STX4 25361965 interaction type N/A PTMCode2
VAMP1 NSF 25361965 interaction type N/A PTMCode2
NSF VAMP1 25361965 interaction type N/A PTMCode2
YKT6 NSF 25361965 interaction type N/A PTMCode2
NSF YKT6 25361965 interaction type N/A PTMCode2
VAPA NSF 25361965 interaction type N/A PTMCode2
NSF VAPA 25361965 interaction type N/A PTMCode2
SNAP23 NSF 25361965 interaction type N/A PTMCode2
NSF SNAP23 25361965 interaction type N/A PTMCode2
STX8 NSF 25361965 interaction type N/A PTMCode2
NSF STX8 25361965 interaction type N/A PTMCode2
STX6 NSF 25361965 interaction type N/A PTMCode2
NSF STX6 25361965 interaction type N/A PTMCode2
GABARAPL2 NSF 25361965 interaction type N/A PTMCode2
NSF GABARAPL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EXOC5 NSF 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
SNW1 NSF 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L NSF 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SAP18 NSF 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
VPS4B NSF 25348397 N/A physical interaction ComPPI
SNAP29 NSF 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STX12 NSF 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAMP3 NSF 25348397 N/A physical interaction ComPPI
TOMM22 NSF 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
STAT1 NSF 25348397 N/A physical interaction ComPPI
VCP NSF 25348397 N/A physical interaction ComPPI
GABARAPL2 NSF 10747018 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
KEAP1 NSF 25348397 N/A physical interaction ComPPI
DPPA4 NSF 25348397 N/A physical interaction ComPPI
EIF3E NSF 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PTPN9 NSF 14525934 15322554 24234451 25348397 dephosphorylation reaction,physical association experimental interaction detection,pull down,phosphatase assay,in vitro ComPPI,HPRD,IntAct
PTPRO NSF 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
GRIA3 NSF 14525934 25348397 9697855 N/A two hybrid,two hybrid ComPPI,HPRD
VAPA NSF 11511104 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CUL3 NSF 25348397 N/A physical interaction ComPPI
KPNB1 NSF 25348397 N/A physical interaction ComPPI
SLC2A4 NSF 25348397 N/A physical interaction ComPPI
CD28 NSF 11680900 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
FES NSF 15322554 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
NTRK1 NSF 25348397 N/A physical interaction ComPPI
USO1 NSF 25348397 N/A in vivo ComPPI
CANX NSF 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PTPRB NSF 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPRG NSF 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
FER NSF 15322554 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
CD247 NSF 24234451 24502978 25348397 association pull down ComPPI,IntAct
PTPN12 NSF 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
SNAP25 NSF 25348397 N/A physical interaction ComPPI
SNAP23 NSF 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GRIA2 NSF 14525934 16724110 24234451 25348397 9697855 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
STX4 NSF 14525934 25348397 27898060 8973549 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
EEA1 NSF 25348397 N/A physical interaction ComPPI
RAP2A NSF 25348397 N/A physical interaction ComPPI
ARRB1 NSF 10196135 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
RPLP1 NSF 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NSF NAPA 14525934 15322554 20562859 24234451 25348397 27898060 7622514 9362506 physical association anti tag coimmunoprecipitation,experimental interaction detection,chromatography technology,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
NSF GOSR1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
NSF GABARAP 11461150 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
NSF STX1A 14525934 25348397 7622514 N/A experimental interaction detection,in vitro ComPPI,HPRD
NSF ERG28 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NSF CEP126 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NSF LUC7L2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NSF DRD2 14525934 15858065 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NSF GABBR2 14525934 16724110 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,imaging technique,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
NSF GABBR1 14525934 16724110 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,imaging technique,in vivo ComPPI,HPRD,IntAct
NSF RGS20 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NSF BABAM1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NSF NAPG 12554740 14525934 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
NSF STX7 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NSF VTI1B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NSF SCFD1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NSF STX6 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NSF STX5 25348397 N/A physical interaction ComPPI
NSF CSNK1G3 25348397 N/A physical interaction ComPPI
NSF PRKAB1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NSF RAB24 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NSF AKT1 25348397 N/A physical interaction ComPPI
NSF PMS2 25348397 N/A physical interaction ComPPI
NSF PMS2CL 25348397 N/A physical interaction ComPPI
NSF IRF2BPL 25348397 N/A physical interaction ComPPI
NSF ADRB2 25348397 N/A physical interaction ComPPI
NSF STAU1 25348397 N/A physical interaction ComPPI
NSF CCDC8 25348397 N/A physical interaction ComPPI
NSF RNF2 25348397 N/A physical interaction ComPPI
NSF EGFR 25348397 N/A physical interaction ComPPI
NSF ESR1 25348397 N/A physical interaction ComPPI
NSF RBKS 25348397 N/A physical interaction ComPPI
NSF HTR6 25348397 N/A physical interaction ComPPI
NSF ASPSCR1 25348397 N/A physical interaction ComPPI
NSF ATP6V0D1 25348397 N/A physical interaction ComPPI
NSF SEC31A 25348397 N/A physical interaction ComPPI
NSF SCLT1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NSF MYH6 25348397 N/A physical interaction ComPPI
NSF RAB4B 25348397 N/A physical interaction ComPPI
NSF MIA 25348397 N/A physical interaction ComPPI
NSF CCDC88A 25348397 N/A physical interaction ComPPI
NSF FOXA3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
NSF FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
NSF FOXQ1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
NSF PCGF1 25348397 N/A physical interaction ComPPI
NSF BCOR 25348397 N/A physical interaction ComPPI
NSF NANOGP8 25348397 N/A physical interaction ComPPI
NSF NANOG 25348397 N/A physical interaction ComPPI
NSF POU5F1 25348397 N/A physical interaction ComPPI
NSF BRCA1 25348397 N/A physical interaction ComPPI
NSF APP 16049941 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NSF NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NSF PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
NSF PTPRK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
NSF PTPRJ 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
NSF BECN1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NSF USE1 19369418 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NSF PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
NSF OCRL 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NSF BET1 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
NSF COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NSF LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NSF RAB9A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NSF TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NSF TOMM20 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
STX8 NSF 10683148 14525934 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PLGRKT NSF 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FUNDC2 NSF 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MRPL9 NSF 25348397 N/A physical interaction ComPPI
NSF NSF 14525934 20562859 24234451 8051214 physical association anti tag coimmunoprecipitation,experimental interaction detection HPRD,IntAct
SRC NSF 15322554 27898060 N/A N/A OmniPath
PTPN1 NSF 19208619 27898060 inhibition N/A OmniPath
PTPN9 NSF 15322554 27898060 inhibition N/A OmniPath
FES NSF 15322554 27898060 N/A N/A OmniPath

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