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GENE：MAP2K3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP2K3
FullNmae mitogen-activated protein kinase kinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6843
EnsembleID ENSG00000034152
Uniprot P46734

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP2K3 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP2K3 GO:0000165,GO:0001817,GO:0002931,GO:0004674,GO:0004708,GO:0004708,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006954,GO:0007165,GO:0007507,GO:0016020,GO:0016310,GO:0019901,GO:0031098,GO:0035331,GO:0035924,GO:0038066,GO:0038066,GO:0043410,GO:0043536,GO:0045860,GO:0045893,GO:0051770,GO:0060048,GO:0071222,GO:0072709,GO:0090398,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP2K3 hsa:5606 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa04218 Cellular senescence - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa04714 Thermogenesis - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa05132 Salmonella infection - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa05135 Yersinia infection - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa05161 Hepatitis B - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
MAP2K3 hsa:5606 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP3K4 MAP2K3 11175814 11274345 12738796 16799472 18855897 21614932 23850759 24104473 26192618 interaction type N/A ACSN
MAP3K7 MAP2K3 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23331499 23681101 24403530 24699077 24958845 26192618 8663074 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
PAK1 MAP2K3 10661401 11062502 11385609 11907067 12885870 14764585 15536084 23331499 26192618 7592586 interaction type,stimulation N/A ACSN,SignaLink
TAB2 MAP2K3 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845 26192618 interaction type N/A ACSN
TAB3 MAP2K3 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845 26192618 interaction type N/A ACSN
MAP3K5 MAP2K3 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23331499 23850759 24378531 26192618 8974401 interaction type,stimulation N/A ACSN,SignaLink
RIPK1 MAP2K3 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type N/A ACSN
TNFRSF1A MAP2K3 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type N/A ACSN
TRADD MAP2K3 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type N/A ACSN
TRAF2 MAP2K3 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 interaction type N/A ACSN
TNFRSF1B MAP2K3 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 interaction type N/A ACSN
MAP2K3 MAPK14 11242034 12384504 12589052 17255949 21071413 23180781 23331499 7839144 9841871 phosphorylation reaction,stimulation,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB,SignaLink,SignaLink
TAOK2 MAP2K3 10497253 11279118 23180781 23331499 phosphorylation reaction,stimulation,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB,SignaLink,SignaLink
MAP2K3 DCTN1 15375157 23180781 physical association two hybrid InnateDB
MAP2K3 MAP2K3 23180781 26467481 7535770 7839144 8622669 9162092 phosphorylation reaction,up-regulates activity in-gel kinase assay InnateDB,Signor
PLCB2 MAP2K3 12054652 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
MAPK3 MAP2K3 23180781 8226933 physical association gst pull down InnateDB
MAP2K3 MAP3K4 23180781 9841871 phosphorylation reaction in-gel kinase assay InnateDB
MAP2K3 ARRB1 16709866 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K3 MAP3K5 16709866 19880523 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K3 DYRK1B 12384504 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K3 MAP3K3 12761204 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MAP2K3 ZFP42 20463961 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K3 MAPK11 11242034 23331499 stimulation N/A SignaLink,SignaLink
MAPK1 MAP2K3 16709866 23331499 stimulation N/A SignaLink,SignaLink
MAP3K11 MAP2K3 23331499 9003778 stimulation N/A SignaLink
TAOK1 MAP2K3 23331499 9786855 stimulation N/A SignaLink
MAP2K3 MAPK13 11242034 23331499 stimulation N/A SignaLink
MAP2K3 MAPK12 11242034 23331499 stimulation N/A SignaLink
MAP3K20 MAP2K3 11836244 23331499 stimulation N/A SignaLink
PAK2 MAP2K3 23331499 7499279 stimulation N/A SignaLink
MAP3K3 MAP2K3 23331499 9162092 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
MAPK8IP2 MAP2K3 20005715 interaction type N/A PSP,SignaLink
NPHS1 MAP2K3 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MAP2K3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MAP2K3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MAP2K3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
AR MAP2K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 MAP2K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP2K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP2K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP2K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAP2K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP2K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MAP2K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MAP2K3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000160683 MAP2K3 19859982 \N rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000160683 MAP2K3 19859982 25416803 26701625 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,clip TarBase
URS0000042E1F MAP2K3 22696064 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000065D58 MAP2K3 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000009262D MAP2K3 24112539 25416803 mrna cleavage,inhibition western blot,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 MAP2K3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00006DE17B MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000024A59E MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000002103A MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000171CD1 MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041CB9C MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000040EE1D MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001799A3 MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000364FEF MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002004E0 MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000F0F49 MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000247AC6 MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005485E8 MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007D64A MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000076E54 MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000023F8DA MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075A608 MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002B0B46 MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000019D79B MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E728C MAP2K3 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAP3K5 MAP2K3 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP2K3 MAP2K3 22135298 phosphorylation N/A PhosphoSite
MAP2K3 MAPK14 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP3K11 MAP2K3 22135298 phosphorylation N/A PhosphoSite
MAP3K8 MAP2K3 22135298 phosphorylation N/A PhosphoSite
MAP2K3 MAP3K5 25361965 interaction type N/A PTMCode2
MAP2K3 MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 MAP2K3 25361965 interaction type N/A PTMCode2
TAOK2 MAP2K3 25361965 interaction type N/A PTMCode2
MAP2K3 TAOK2 25361965 interaction type N/A PTMCode2
PKN1 MAP2K3 25361965 interaction type N/A PTMCode2
MAP2K3 PKN1 25361965 interaction type N/A PTMCode2
SMAD7 MAP2K3 25361965 interaction type N/A PTMCode2
MAP2K3 SMAD7 25361965 interaction type N/A PTMCode2
ELK1 MAP2K3 25361965 interaction type N/A PTMCode2
MAP2K3 ELK1 25361965 interaction type N/A PTMCode2
MAPK14 MAP2K3 25361965 interaction type N/A PTMCode2
MAPK8IP2 MAP2K3 25361965 interaction type N/A PTMCode2
MAP2K3 MAPK8IP2 25361965 interaction type N/A PTMCode2
TAOK1 MAP2K3 25361965 interaction type N/A PTMCode2
MAP2K3 TAOK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 MAP2K3 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAD2L2 MAP2K3 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
SMAD7 MAP2K3 25348397 N/A physical interaction,in vitro,in vivo ComPPI
MAPK3 MAP2K3 25348397 N/A physical interaction,in vitro ComPPI
MAPK14 MAP2K3 17255949 23602568 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,in vitro,tandem affinity purification ComPPI,IntAct
PKN1 MAP2K3 12761180 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K5 MAP2K3 19805025 21771788 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K4 MAP2K3 24234451 25241761 25348397 physical association physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,IntAct
MAPK8IP3 MAP2K3 25348397 N/A physical interaction ComPPI
HNRNPL MAP2K3 25348397 N/A physical interaction ComPPI
ELK1 MAP2K3 25348397 N/A in vitro ComPPI
DCTN1 MAP2K3 25348397 N/A two hybrid,in vitro ComPPI
DYRK1B MAP2K3 11980910 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,protein kinase assay,in vivo ComPPI,IntAct
MAPK8IP1 MAP2K3 25348397 N/A physical interaction ComPPI
MAPK8IP2 MAP2K3 25348397 N/A physical interaction,in vivo ComPPI
ARRB1 MAP2K3 25348397 N/A physical interaction ComPPI
EGFR MAP2K3 25348397 N/A physical interaction ComPPI
CD70 MAP2K3 25348397 N/A physical interaction ComPPI
MAP2K6 MAP2K3 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
MAPK12 MAP2K3 25348397 N/A in vitro ComPPI
SPAG9 MAP2K3 25348397 N/A physical interaction ComPPI
TAOK2 MAP2K3 24234451 25241761 25348397 physical association physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,IntAct
ALDOC MAP2K3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAP2K3 PLCB2 25348397 N/A two hybrid,physical interaction,in vivo ComPPI
MAP2K3 TAOK1 25348397 N/A in vitro ComPPI
MAP2K3 RPL13 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP2K3 TINF2 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
MAP2K3 PTPA 25348397 N/A physical interaction ComPPI
MAP2K3 MAP3K2 25348397 N/A physical interaction ComPPI
MAP2K3 MAP3K3 25348397 N/A physical interaction ComPPI
MAP2K3 LRRK2 20067578 20173330 24234451 25348397 physical association anti tag coimmunoprecipitation,coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K3 APP 25348397 N/A physical interaction ComPPI
MAP2K3 MYH6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K3 FOXA3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MAP2K3 FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MAP2K3 FOXS1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MAP2K3 DUSP2 25348397 N/A physical interaction ComPPI
MAP2K3 TRIM25 25348397 N/A physical interaction ComPPI
MAP2K3 TES 25348397 N/A physical interaction ComPPI
HSCB MAP2K3 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
MAP2K3 PLCB2 12054652 16189514 27898060 N/A N/A OmniPath
PLCB2 MAP2K3 12054652 16189514 27898060 N/A N/A OmniPath
ARRB1 MAP2K3 16709866 27898060 N/A N/A OmniPath
MAP3K7 MAP2K3 12791976 17299140 21902831 27898060 stimulant N/A OmniPath
MAP3K8 MAP2K3 17637696 27898060 stimulant N/A OmniPath
MAP2K3 MAPK13 11242034 18083107 27898060 9374491 stimulant N/A OmniPath
MAP2K3 MAP3K5 11274345 12738796 16709866 18855897 19880523 19920149 21614932 21771788 27898060 N/A N/A OmniPath
MAP3K5 MAP2K3 11029458 11274345 12738796 16709866 18855897 19880523 19920149 21614932 21771788 27898060 stimulant N/A OmniPath
MAP2K3 MAPK3 27898060 8226933 N/A N/A OmniPath
MAP2K3 MAPK14 11279118 11426938 12384504 12589052 15592455 16083285 16189514 17081983 17192257 17255949 17322306 17389395 18083107 18088087 18669648 18691976 18767875 19369195 19534553 19651622 19690332 20068231 20213747 23602568 26186194 27898060 7535770 7750576 7839144 8622669 9162092 9841871 stimulant N/A OmniPath
MAPK1 MAP2K3 16709866 27898060 stimulant N/A OmniPath
PAK1 MAP2K3 27898060 7592586 stimulant N/A OmniPath
MAP2K3 MAP3K4 11274345 12738796 15866172 18855897 21614932 25241761 27898060 9305639 9841871 N/A N/A OmniPath
MAP3K4 MAP2K3 11274345 12738796 15866172 18855897 21614932 25241761 27898060 9305639 9841871 stimulant N/A OmniPath
PAK2 MAP2K3 27898060 7499279 stimulant N/A OmniPath
MAP2K3 MAPK11 11242034 18083107 19369195 27898060 stimulant N/A OmniPath
MAP3K3 MAP2K3 12761204 27898060 9162092 stimulant N/A OmniPath
MAP2K3 TAOK2 10497253 11279118 25241761 27898060 9786855 N/A N/A OmniPath
TAOK2 MAP2K3 10497253 11279118 25241761 27898060 9786855 stimulant N/A OmniPath
MAP2K3 MAPK12 11062067 11242034 18083107 19413330 27898060 stimulant N/A OmniPath
TAOK1 MAP2K3 10497253 27898060 9786855 stimulant N/A OmniPath
MAP3K20 MAP2K3 11836244 27898060 stimulant N/A OmniPath
MAP2K3 DYRK1B 11980910 12384504 27898060 stimulant N/A OmniPath
MAP3K11 MAP2K3 27898060 9003778 stimulant N/A OmniPath
MAP2K3 DCTN1 15375157 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BD1C2 MAP2K3 27087310 direct interaction,inhibition N/A NPInter

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