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GENE：PARS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PARS2
FullNmae prolyl-tRNA synthetase 2, mitochondrial
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30563
EnsembleID ENSG00000162396
Uniprot Q7L3T8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PARS2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PARS2 GO:0004827,GO:0005524,GO:0005739,GO:0005759,GO:0006433,GO:0042802

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PARS2 hsa:25973 path:hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 PARS2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 PARS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PARS2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF PARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000004BACE PARS2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D PARS2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000036AFF1 PARS2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000009A9A2 PARS2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 PARS2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 PARS2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D PARS2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075A608 PARS2 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKAA2 PARS2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN PARS2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
DLD PARS2 25348397 N/A physical interaction ComPPI
SQSTM1 PARS2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
EPRS1 PARS2 25348397 N/A physical interaction ComPPI
HSPB9 PARS2 25348397 N/A physical interaction ComPPI
PARS2 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct

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