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GENE：PCBP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PCBP2
FullNmae poly(rC) binding protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8648
EnsembleID ENSG00000197111
Uniprot Q15366

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PCBP2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PCBP2 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PCBP2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PCBP2 GO:0003697,GO:0003723,GO:0003723,GO:0003729,GO:0005515,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005925,GO:0010468,GO:0014069,GO:0016020,GO:0016071,GO:0019899,GO:0031625,GO:0039694,GO:0043161,GO:0045087,GO:0045824,GO:0045944,GO:0050687,GO:0051252,GO:0051607,GO:0070062,GO:0075522,GO:1990829,GO:1990904

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PCBP2 hsa:5094 path:hsa04216 Ferroptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PCBP2 MAPKAP1 18687895 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNAR2 PCBP2 18687895 23180781 physical association anti tag coimmunoprecipitation InnateDB
PCBP2 MAVS 19881509 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
PCBP2 IFIH1 19881509 23180781 physical association anti tag coimmunoprecipitation InnateDB
PCBP2 DDX58 19881509 23180781 physical association anti tag coimmunoprecipitation InnateDB
PCBP2 ITCH 19881509 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAVS PCBP2 19881509 23180781 physical association anti tag coimmunoprecipitation InnateDB
EED PCBP2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
ADRB2 PCBP2 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PCBP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PCBP2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PCBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PCBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PCBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PCBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PCBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PCBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PCBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PCBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR PCBP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003D5391 PCBP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD PCBP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 PCBP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B PCBP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 PCBP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 PCBP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EED18 PCBP2 24796666 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS00002075FA PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003CC709 PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000072E4C PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000393C7 PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA PCBP2 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 PCBP2 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB PCBP2 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002CBC6D PCBP2 20371350 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HNRNPD PCBP2 25361965 interaction type N/A PTMCode2
PCBP2 HNRNPD 25361965 interaction type N/A PTMCode2
PCBP1 PCBP2 25361965 interaction type N/A PTMCode2
PCBP2 PCBP1 25361965 interaction type N/A PTMCode2
POLR2L PCBP2 25361965 interaction type N/A PTMCode2
PCBP2 POLR2L 25361965 interaction type N/A PTMCode2
HNRNPL PCBP2 25361965 interaction type N/A PTMCode2
PCBP2 HNRNPL 25361965 interaction type N/A PTMCode2
PCBP2 HNRNPK 25361965 interaction type N/A PTMCode2
HNRNPK PCBP2 25361965 interaction type N/A PTMCode2
CNBP PCBP2 25361965 interaction type N/A PTMCode2
PCBP2 CNBP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 PCBP2 25348397 N/A physical interaction ComPPI
HNRNPK PCBP2 10772858 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SLU7 PCBP2 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LGALS3 PCBP2 25348397 N/A physical interaction ComPPI
SNW1 PCBP2 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CDC5L PCBP2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SNRPA PCBP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PPIB PCBP2 25348397 N/A physical interaction ComPPI
FTH1 PCBP2 25348397 N/A physical interaction ComPPI
PCBP1 PCBP2 14525934 16713569 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
UBL4A PCBP2 25348397 N/A physical interaction ComPPI
KEAP1 PCBP2 25348397 N/A physical interaction ComPPI
WDR83 PCBP2 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MCM2 PCBP2 25348397 N/A physical interaction ComPPI
RACK1 PCBP2 25348397 N/A physical interaction ComPPI
CD81 PCBP2 25348397 N/A physical interaction ComPPI
JUN PCBP2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
HMGA1 PCBP2 25348397 N/A physical interaction ComPPI
COPS5 PCBP2 25348397 N/A physical interaction ComPPI
PSMA3 PCBP2 25348397 N/A physical interaction ComPPI
FLNA PCBP2 14525934 25348397 8871564 N/A two hybrid,two hybrid ComPPI,HPRD
PAXIP1 PCBP2 25348397 N/A physical interaction ComPPI
CUL3 PCBP2 25348397 N/A physical interaction ComPPI
SCYL2 PCBP2 25348397 N/A physical interaction ComPPI
UBC PCBP2 25348397 N/A physical interaction ComPPI
NTRK1 PCBP2 25348397 N/A physical interaction ComPPI
CDH1 PCBP2 25348397 N/A physical interaction ComPPI
RUVBL1 PCBP2 25348397 N/A physical interaction ComPPI
PRPF40A PCBP2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
YBX1 PCBP2 14525934 25348397 8871564 N/A two hybrid,two hybrid ComPPI,HPRD
STIP1 PCBP2 25348397 N/A physical interaction ComPPI
GBA PCBP2 25348397 N/A physical interaction ComPPI
MYC PCBP2 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
MAGI3 PCBP2 25348397 N/A physical interaction ComPPI
TRIP6 PCBP2 25348397 N/A physical interaction ComPPI
EEF1A1 PCBP2 25348397 N/A physical interaction ComPPI
CD247 PCBP2 24234451 24502978 25348397 association pull down ComPPI,IntAct
HNRNPL PCBP2 10772858 14525934 21623344 24234451 25348397 8871564 association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
CFTR PCBP2 25348397 N/A physical interaction ComPPI
PABPC1 PCBP2 10373504 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
ANG PCBP2 24234451 25348397 28777577 association anti bait coimmunoprecipitation ComPPI,IntAct
CASK PCBP2 25348397 N/A physical interaction ComPPI
HUWE1 PCBP2 25348397 N/A physical interaction ComPPI
CUL2 PCBP2 25348397 N/A physical interaction ComPPI
WDR77 PCBP2 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PAPOLA PCBP2 21623344 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CDK2 PCBP2 25348397 N/A physical interaction ComPPI
CUL1 PCBP2 25348397 N/A physical interaction ComPPI
ADRB2 PCBP2 25348397 N/A physical interaction ComPPI
ANXA2 PCBP2 25348397 N/A physical interaction ComPPI
YBX3 PCBP2 14525934 25348397 8871564 N/A two hybrid,two hybrid ComPPI,HPRD
URI1 PCBP2 25348397 N/A physical interaction ComPPI
CHEK2 PCBP2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
FUBP1 PCBP2 25348397 N/A physical interaction ComPPI
KAT2A PCBP2 25348397 N/A physical interaction ComPPI
ITCH PCBP2 25348397 N/A physical interaction ComPPI
ACAT2 PCBP2 25348397 N/A physical interaction ComPPI
NOS2 PCBP2 25348397 N/A physical interaction ComPPI
VCAM1 PCBP2 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 PCBP2 25348397 N/A physical interaction ComPPI
EED PCBP2 25348397 N/A physical interaction ComPPI
CUL7 PCBP2 25348397 N/A physical interaction ComPPI
HDAC5 PCBP2 25348397 N/A physical interaction ComPPI
CDK9 PCBP2 25348397 N/A physical interaction ComPPI
QKI PCBP2 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
SRSF3 PCBP2 14525934 17183366 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
NFKB1 PCBP2 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
BARD1 PCBP2 25348397 N/A physical interaction ComPPI
TIAL1 PCBP2 25348397 N/A physical interaction ComPPI
SYMPK PCBP2 21623344 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PTBP1 PCBP2 10772858 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
ELAVL1 PCBP2 25348397 N/A physical interaction ComPPI
PCBP2 HNRNPD 14525934 25348397 9234743 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PCBP2 CNBP 14525934 17327219 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
PCBP2 SRSF7 25348397 N/A two hybrid,in vivo ComPPI
PCBP2 MEPCE 25348397 N/A physical interaction ComPPI
PCBP2 RUVBL2 25348397 N/A physical interaction ComPPI
PCBP2 POLR3H 25348397 N/A physical interaction ComPPI
PCBP2 H2AX 20000738 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PCBP2 MAVS 25348397 N/A physical interaction ComPPI
PCBP2 IFIH1 25348397 N/A physical interaction ComPPI
PCBP2 FBXO6 25348397 N/A physical interaction ComPPI
PCBP2 EEF1A1P5 25348397 N/A physical interaction ComPPI
PCBP2 FN1 25348397 N/A physical interaction ComPPI
PCBP2 SF3B2 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PCBP2 NKAP 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PCBP2 BRCA1 25348397 N/A physical interaction ComPPI
PCBP2 IGSF8 25348397 N/A physical interaction ComPPI
PCBP2 HMGA2 25348397 N/A physical interaction ComPPI
PCBP2 TARDBP 25348397 N/A physical interaction ComPPI
PCBP2 CEP250 25348397 N/A physical interaction ComPPI
PCBP2 FUS 25348397 N/A physical interaction ComPPI
PCBP2 PHF6 25348397 N/A physical interaction ComPPI
PCBP2 OBSL1 25348397 N/A physical interaction ComPPI
PCBP2 CCDC8 25348397 N/A physical interaction ComPPI
PCBP2 HNRNPA1 25348397 N/A physical interaction ComPPI
PCBP2 ANXA2P2 25348397 N/A physical interaction ComPPI
PCBP2 ARF5 25348397 N/A physical interaction ComPPI
PCBP2 MIX23 25348397 N/A physical interaction ComPPI
PCBP2 DAZAP1 25348397 N/A physical interaction ComPPI
PCBP2 FUBP3 25348397 N/A physical interaction ComPPI
PCBP2 KIF2C 25348397 N/A physical interaction ComPPI
PCBP2 LGALS1 25348397 N/A physical interaction ComPPI
PCBP2 TIA1 25348397 N/A physical interaction ComPPI
PCBP2 UBE2M 25348397 N/A physical interaction ComPPI
PCBP2 CYLD 25348397 N/A physical interaction ComPPI
PCBP2 AGO1 17932509 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PCBP2 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PCBP2 CPSF3 21623344 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PCBP2 CPSF2 21623344 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PCBP2 DUX4 24234451 25348397 26816005 association pull down ComPPI,IntAct
PCBP2 DUX4L9 24234451 25348397 26816005 association pull down ComPPI,IntAct
PCBP2 IGF2BP1 19029303 24234451 25348397 colocalization,association anti tag coimmunoprecipitation,confocal microscopy ComPPI,IntAct
PCBP2 RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PCBP2 EZR 24234451 25348397 29568061 association pull down ComPPI,IntAct
ARF4 PCBP2 25348397 N/A physical interaction ComPPI
CPSF1 PCBP2 21623344 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
DDX41 PCBP2 24234451 25348397 25920683 association anti tag coimmunoprecipitation ComPPI,IntAct
GNPNAT1 PCBP2 25348397 N/A physical interaction ComPPI
PCBP2 PCBP2 10772858 14525934 16186123 22365833 24234451 physical association two hybrid,experimental interaction detection,two hybrid HPRD,IntAct
METTL3 PCBP2 24234451 29507755 association anti tag coimmunoprecipitation IntAct
WTAP PCBP2 24234451 29507755 association anti tag coimmunoprecipitation IntAct
METTL14 PCBP2 24234451 29507755 association anti tag coimmunoprecipitation IntAct
PCBP2 VCP 24234451 30021884 physical association cross-linking study IntAct
MAVS PCBP2 19881509 27898060 N/A N/A OmniPath
DDX58 PCBP2 19881509 27898060 N/A N/A OmniPath
PCBP2 IFIH1 19881509 27898060 N/A N/A OmniPath
IFNAR2 PCBP2 18687895 27898060 N/A N/A OmniPath

Visualization










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