Gene Information gene info

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GENE：PDE12

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDE12
FullNmae phosphodiesterase 12
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25386
EnsembleID ENSG00000174840
Uniprot Q6L8Q7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDE12 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PDE12 GO:0000175,GO:0000175,GO:0000288,GO:0000288,GO:0000958,GO:0004527,GO:0004535,GO:0005739,GO:0005759,GO:0005759,GO:0005829,GO:0006397,GO:0034611,GO:0035457,GO:0044528,GO:0045070,GO:0046872,GO:0051607,GO:0071346,GO:0071359,GO:0090305,GO:0140374

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 PDE12 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A PDE12 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 PDE12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PDE12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PDE12 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 PDE12 17699775 18668040 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,clip TarBase
URS0000338542 PDE12 18668040 22473208 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS000003ABC4 PDE12 19088304 23824327 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS0000070B1D PDE12 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE PDE12 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000052E1A6 PDE12 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 PDE12 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 PDE12 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 PDE12 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 PDE12 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D PDE12 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD PDE12 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 PDE12 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000037E170 PDE12 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 PDE12 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004F24A9 PDE12 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004AF715 PDE12 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003D8730 PDE12 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000F7766 PDE12 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000CBE63 PDE12 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000081E1F PDE12 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B PDE12 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005CCD18 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002B2B5C PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002A71AD PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000260A3A PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 PDE12 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 PDE12 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E PDE12 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 PDE12 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A PDE12 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 PDE12 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 PDE12 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D PDE12 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C PDE12 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F PDE12 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 PDE12 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C7662 PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000038718E PDE12 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CUL5 PDE12 25348397 N/A physical interaction ComPPI
CHCHD2 PDE12 25348397 N/A physical interaction ComPPI
COPS5 PDE12 25348397 N/A physical interaction ComPPI
PGGT1B PDE12 25348397 N/A physical interaction ComPPI
CUL3 PDE12 25348397 N/A physical interaction ComPPI
UBC PDE12 25348397 N/A physical interaction ComPPI
NTRK1 PDE12 25348397 N/A physical interaction ComPPI
BAG6 PDE12 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APEX2 PDE12 25348397 N/A physical interaction ComPPI
PDLIM5 PDE12 25348397 N/A physical interaction ComPPI
UBQLN2 PDE12 25348397 N/A physical interaction ComPPI
SAE1 PDE12 25348397 N/A physical interaction ComPPI
UBA2 PDE12 25348397 N/A physical interaction ComPPI
CUL1 PDE12 25348397 N/A physical interaction ComPPI
STAT6 PDE12 25348397 N/A physical interaction ComPPI
RAD23B PDE12 25348397 N/A physical interaction ComPPI
PDK1 PDE12 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DNAJB1 PDE12 25348397 N/A physical interaction ComPPI
BRCA1 PDE12 25348397 N/A physical interaction ComPPI
SORT1 PDE12 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NPLOC4 PDE12 25348397 N/A physical interaction ComPPI
EHD1 PDE12 25348397 N/A physical interaction ComPPI
HSPD1 PDE12 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
WDR4 PDE12 25348397 N/A physical interaction ComPPI
APEX1 PDE12 25348397 N/A physical interaction ComPPI
ADSL PDE12 25348397 N/A physical interaction ComPPI
PDE12 SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
TRMT61B PDE12 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NCBP3 PDE12 24234451 26382858 association pull down IntAct

Visualization










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