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GENE：PDE3B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDE3B
FullNmae phosphodiesterase 3B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8779
EnsembleID ENSG00000152270
Uniprot Q13370

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDE3B cuproptosis 36882769 In addition, copper can also regulate PDE3B or S6K1 and thus modulates tumor metabolism. regulator
PDE3B cuproptosis 38006800 As for CRG, 19 CRGs(CP,CD274,PDE3B,DLAT,VEGFA,DBH,COX11,COA6,PDK1,SLC31A2,UBE2D1,UlK1,SLC25A3,MTF1,UBE2D3,SLC31A1,MAP2K1,AOC3,CCL8) were significantly differentially expressed in the Control and sepsis induced cardiotoxicity groups in GSE44363 cuproptosis-related genes
PDE3B cuproptosis 38341588 At the same time, copper is also a dynamic signaling metal and metal allosteric regulator, such as copper-dependent phosphodiesterase 3B (PDE3B) in lipolysis, mitogen-activated protein kinase kinase 1 (MEK1) in cell growth and proliferation and MEK2, the kinases ULK1 and ULK2 in autophagy. Cell proliferation that relies on copper is called copper hyperplasia, which corresponds to this article about copper death. These enzymes may have some interactions with FDX1 signaling, which may be a focus of future research. interactions with FDX1
PDE3B cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
PDE3B cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes
PDE3B cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PDE3B GO:0001525,GO:0004114,GO:0004114,GO:0004115,GO:0004115,GO:0004115,GO:0004119,GO:0005515,GO:0005783,GO:0005794,GO:0005829,GO:0007162,GO:0007165,GO:0007186,GO:0016020,GO:0016020,GO:0016020,GO:0016525,GO:0032045,GO:0032869,GO:0033629,GO:0043422,GO:0043422,GO:0043951,GO:0043951,GO:0046872,GO:0047555,GO:0050995

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PDE3B hsa:5140 path:hsa00230 Purine metabolism - Homo sapiens (human)
PDE3B hsa:5140 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PDE3B hsa:5140 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
PDE3B hsa:5140 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
PDE3B hsa:5140 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
PDE3B hsa:5140 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
PDE3B hsa:5140 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
PDE3B hsa:5140 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
PDE3B hsa:5140 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
PDE3B hsa:5140 path:hsa04924 Renin secretion - Homo sapiens (human)
PDE3B hsa:5140 path:hsa05032 Morphine addiction - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PDE3B CEBPD 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
YWHAB PDE3B 20005715 interaction type N/A PSP
YWHAB PDE3B 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GATA2 PDE3B 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PDE3B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PDE3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PDE3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PDE3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PDE3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PDE3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PDE3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PDE3B 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002C0FCB PDE3B 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000DDD35 PDE3B 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA PDE3B 22135298 phosphorylation N/A PhosphoSite
AKT1 PDE3B 25361965 interaction type N/A PTMCode2
PDE3B AKT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HPGDS PDE3B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TEX264 PDE3B 25348397 N/A physical interaction ComPPI
PIK3CG PDE3B 21393242 24234451 25348397 association,physical association anti bait coimmunoprecipitation ComPPI,IntAct
PDGFRB PDE3B 25348397 N/A physical interaction ComPPI
HNRNPL PDE3B 25348397 N/A physical interaction ComPPI
YWHAQ PDE3B 25348397 N/A physical interaction ComPPI
IL9R PDE3B 25348397 N/A physical interaction ComPPI
ANKRA2 PDE3B 25348397 N/A physical interaction ComPPI
RAPGEF3 PDE3B 21393242 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,peptide array,pull down,imaging technique ComPPI,IntAct
CD79B PDE3B 25348397 N/A physical interaction ComPPI
LNX1 PDE3B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GNAI1 PDE3B 25348397 N/A physical interaction ComPPI
KCNS3 PDE3B 25348397 N/A physical interaction ComPPI
SLC8A3 PDE3B 25348397 N/A physical interaction ComPPI
HLA-DRB1 PDE3B 25348397 N/A physical interaction ComPPI
TMPRSS3 PDE3B 25348397 N/A physical interaction ComPPI
TEX28 PDE3B 25348397 N/A physical interaction ComPPI
FAM189A2 PDE3B 25348397 N/A physical interaction ComPPI
SRPRB PDE3B 25348397 N/A physical interaction ComPPI
EVA1C PDE3B 25348397 N/A physical interaction ComPPI
ZNRF4 PDE3B 25348397 N/A physical interaction ComPPI
RNF170 PDE3B 25348397 N/A physical interaction ComPPI
TMEM59 PDE3B 25348397 N/A physical interaction ComPPI
PDE3B SLC39A4 25348397 N/A physical interaction ComPPI
PDE3B CHRNA9 25348397 N/A physical interaction ComPPI
PDE3B LRRTM2 25348397 N/A physical interaction ComPPI
PDE3B LRRTM1 25348397 N/A physical interaction ComPPI
PDE3B PCDHAC2 25348397 N/A physical interaction ComPPI
PDE3B IL17RC 25348397 N/A physical interaction ComPPI
PDE3B FAM189B 25348397 N/A physical interaction ComPPI
PDE3B KCNC4 25348397 N/A physical interaction ComPPI
PDE3B LRRC8B 25348397 N/A physical interaction ComPPI
PDE3B PIK3R6 21393242 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,peptide array ComPPI,IntAct
PDE3B YWHAB 12453887 14525934 27898060 N/A experimental interaction detection,two hybrid HPRD,OmniPath
PRKACA PDE3B 10454575 14525934 8163498 8626720 N/A experimental interaction detection HPRD
AKT1 PDE3B 10454575 14525934 N/A experimental interaction detection HPRD
PRKACA PDE3B 10454575 17255105 26031333 27898060 2839485 8163498 8626720 stimulant N/A OmniPath
LYN PDE3B 17255105 27898060 8163498 8626720 N/A N/A OmniPath
AKT1 PDE3B 10454575 18669648 27898060 stimulant N/A OmniPath

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