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GENE：PDHX

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDHX
FullNmae pyruvate dehydrogenase complex component X
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21350
EnsembleID ENSG00000110435
Uniprot O00330

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDHX cuproptosis 38348451 unknown CRGs in the cuproptosis pathway
PDHX cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PDHX GO:0005515,GO:0005739,GO:0005739,GO:0005759,GO:0005967,GO:0005967,GO:0006086,GO:0006086,GO:0006086,GO:0016746,GO:0034604,GO:0045254,GO:0045254

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PDHX hsa:8050 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PDHX 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 PDHX 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PDHX 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PDHX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PDHX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PDHX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PDHX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 PDHX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PDHX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PDHX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PDHX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PDHX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PDHX 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF6 PDHX 18450959 trascriptional regulation,stimulation inferred by curator TFlink
KLF11 PDHX 19843526 trascriptional regulation,stimulation inferred by curator TFlink
PAX6 PDHX 12783165 trascriptional regulation,stimulation inferred by curator TFlink
SREBF1 PDHX 16091421 trascriptional regulation,stimulation inferred by curator TFlink
USF2 PDHX 10393088 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000272A3D PDHX 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000003ABC4 PDHX 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000324096 PDHX 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000236310 PDHX 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 PDHX 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD PDHX 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000171CD1 PDHX 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004719AB PDHX 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 PDHX 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 PDHX 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F PDHX 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 PDHX 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DLD PDHX 25361965 interaction type N/A PTMCode2
PDHX DLD 25361965 interaction type N/A PTMCode2
PDHX DLAT 25361965 interaction type N/A PTMCode2
DLAT PDHX 25361965 interaction type N/A PTMCode2
PDHX PDHA1 25361965 interaction type N/A PTMCode2
PDHA1 PDHX 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LGALS3 PDHX 25348397 N/A physical interaction ComPPI
CDKN1A PDHX 25348397 N/A physical interaction ComPPI
NF2 PDHX 25348397 N/A physical interaction ComPPI
JUN PDHX 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
EP300 PDHX 11756538 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DLD PDHX 14525934 16263718 16442803 24234451 25348397 27898060 physical association experimental interaction detection,isothermal titration calorimetry,x-ray crystallography,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct,OmniPath
ACTN1 PDHX 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
STAT5A PDHX 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STAT5B PDHX 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AGTRAP PDHX 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EWSR1 PDHX 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EIF3C PDHX 25348397 N/A physical interaction ComPPI
PDHB PDHX 14525934 25348397 7864652 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PDHX PDK2 12573248 12816949 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PDHX DLAT 14525934 14638692 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
PDHX PDHA1 25348397 N/A physical interaction ComPPI
PDHX OGDH 25348397 N/A physical interaction ComPPI
PDHX SLC25A3 25348397 N/A physical interaction ComPPI
PDHX ABCC1 25348397 N/A physical interaction ComPPI
PDHX MTARC1 25348397 N/A physical interaction ComPPI
PDHX LGR4 25348397 N/A physical interaction ComPPI
PDHX NXF1 25348397 N/A physical interaction ComPPI
PDHX NEUROD1 25348397 N/A physical interaction ComPPI
PDHX PDK1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PDHX CS 25348397 N/A physical interaction ComPPI
PDHX HDAC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDHX HSD17B10 25348397 N/A physical interaction ComPPI
PDHX PDK3 25348397 N/A physical interaction ComPPI
PDHX FOXD4 25348397 N/A physical interaction ComPPI
PDHX MTIF2 25348397 N/A physical interaction ComPPI
PDHX PREPL 25348397 N/A physical interaction ComPPI
PDHX SIRT4 24234451 25348397 25525879 lipoprotein cleavage reaction,colocalization,association anti tag coimmunoprecipitation,confocal microscopy,lipoprotein cleavage assay ComPPI,IntAct
PDHX CIDEB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSCB PDHX 24234451 24606901 25348397 28380382 association,physical association anti bait coimmunoprecipitation,two hybrid ComPPI,IntAct
STK38L PDHX 24234451 30108113 association proximity-dependent biotin identification IntAct
PDHX PAX6 12783165 27898060 inhibition N/A OmniPath
PDHX CDX2 12783165 27898060 inhibition N/A OmniPath

Visualization










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