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GENE：MAP3K12

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP3K12
FullNmae mitogen-activated protein kinase kinase kinase 12
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6851
EnsembleID ENSG00000139625
Uniprot Q12852

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP3K12 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP3K12 GO:0004672,GO:0004674,GO:0004706,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007254,GO:0016020,GO:0018105,GO:0019901,GO:0030426,GO:0035556,GO:0042803,GO:0043507,GO:0043539,GO:0043687,GO:0045860,GO:0045893,GO:0046777,GO:0070374,GO:0106310,GO:2000672

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP3K12 hsa:7786 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP3K12 MAP2K4 23331499 8637721 stimulation N/A SignaLink
MAPK8IP1 MAP3K12 10490659 23331499 9868371 stimulation N/A SignaLink
MBIP MAP3K12 10801814 23331499 stimulation N/A SignaLink
SH3RF1 MAP3K12 12514131 23331499 stimulation N/A SignaLink
MAP3K12 MAP2K7 15749080 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
MAPK8IP1 MAP3K12 20005715 interaction type N/A PSP
MAPK8IP2 MAP3K12 20005715 interaction type N/A PSP
MAPK8IP1 MAP3K12 20005715 20005715 N/A N/A SignaLink
MAPK8IP2 MAP3K12 10490659 10490659 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MAP3K12 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MAP3K12 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MAP3K12 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C MAP3K12 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MAP3K12 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA MAP3K12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP3K12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MAP3K12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP3K12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MAP3K12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR MAP3K12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP3 MAP3K12 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002075FA MAP3K12 19666108 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000042E1F MAP3K12 19666108 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000042E1F MAP3K12 19666108 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002075FA MAP3K12 19666108 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000003ABC4 MAP3K12 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000427B68 MAP3K12 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB MAP3K12 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 MAP3K12 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 MAP3K12 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 MAP3K12 25416803 25999017 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAP3K12 MYL12B 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
FTL MAP3K12 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HSP90AB1 MAP3K12 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
RPL18A MAP3K12 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TGM2 MAP3K12 25348397 N/A in vitro ComPPI
HSP90AA1 MAP3K12 25348397 N/A physical interaction ComPPI
MAP2K4 MAP3K12 25348397 N/A in vitro ComPPI
HNRNPL MAP3K12 25348397 N/A physical interaction ComPPI
MAPK6 MAP3K12 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP1 MAP3K12 25348397 N/A physical interaction,in vivo ComPPI
MAPK8IP2 MAP3K12 25348397 N/A physical interaction,in vivo ComPPI
MAP3K11 MAP3K12 25348397 N/A in vitro,in vivo ComPPI
EGFR MAP3K12 20029029 24234451 25348397 association,physical association anti bait coimmunoprecipitation,ubiquitin reconstruction,physical interaction ComPPI,IntAct
MAP3K12 MAP2K7 25348397 N/A physical interaction,in vitro,in vivo ComPPI
MAP3K12 MBIP 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
MAP3K12 SH3RF1 25348397 N/A in vitro ComPPI
MAP3K12 TSC22D1 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP3K12 FRA10AC1 16169070 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP3K12 RGS1 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP3K12 ELAVL1 25348397 N/A physical interaction ComPPI
MAP3K12 HSP90AA2P 25348397 N/A physical interaction ComPPI
SH3RF1 MAP3K12 11416147 12514131 14504284 27898060 stimulant N/A OmniPath
MAP3K12 MAP2K4 10187804 19369195 27898060 stimulant N/A OmniPath
MAP3K12 MAP2K6 16728640 19369195 27898060 N/A N/A OmniPath
MAPK8IP1 MAP3K12 10490659 11432832 27898060 inhibition N/A OmniPath
MAP3K12 MYL12B 11781833 27898060 stimulant N/A OmniPath

Visualization










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