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GENE：PDK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDK1
FullNmae pyruvate dehydrogenase kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8809
EnsembleID ENSG00000152256
Uniprot Q15118

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDK1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PDK1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PDK1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PDK1 cuproptosis 36882769 Copper directly binds or activates EGFR, PDK1 or PI3K to promotes tumorigenesis. regulator
PDK1 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
PDK1 cuproptosis 38348451 Genes related to pyruvate metabolism. Changes in pyruvate metabolism can influence cellular energetics and contribute to cell death. CRGs in the cuproptosis pathway
PDK1 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
PDK1 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PDK1 GO:0004672,GO:0004740,GO:0004740,GO:0004740,GO:0004740,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0006468,GO:0008283,GO:0008631,GO:0010510,GO:0010906,GO:0010906,GO:0016310,GO:0097411

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PDK1 hsa:5163 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
PDK1 hsa:5163 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PDK1 DLD 26192618 interaction type N/A ACSN
HIF1A PDK1 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 26192618 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622 interaction type N/A ACSN
MYC PDK1 11274345 11283613 11283614 11704864 16517405 16517406 17055429 17558397 17785433 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 26192618 28536364 interaction type N/A ACSN
AKT1 PDK1 23180781 9512493 phosphorylation reaction protein kinase assay InnateDB
AKT2 PDK1 23180781 9512493 phosphorylation reaction protein kinase assay InnateDB
RPS6KB1 PDK1 16286006 23180781 physical association anti tag coimmunoprecipitation InnateDB
NPRL2 PDK1 18616680 23180781 physical association anti tag coimmunoprecipitation InnateDB
SRC PDK1 18616680 23180781 phosphorylation reaction protein kinase assay InnateDB
PDK1 AKT1 11344272 11752451 11943559 21071413 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
RPTOR PDK1 20005715 interaction type N/A PSP
YWHAQ PDK1 20005715 interaction type N/A PSP
RPTOR PDK1 12150926 20005715 20005715 21071413 N/A N/A SignaLink
YWHAQ PDK1 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
E2F4 PDK1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 PDK1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PDK1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PDK1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PDK1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PDK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PDK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PDK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PDK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PDK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PDK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PDK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PDK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PDK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
JUN PDK1 19910471 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 PDK1 20215506 21533613 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS00000ED600 PDK1 18591395 18927107 20215506 21533613 22743998 24137444 24481267 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,miRDeathDB,TarBase
URS0000338542 PDK1 18668040 22473208 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS000003ABC4 PDK1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000324096 PDK1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001B341F PDK1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 PDK1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000040780F PDK1 25416803 26084420 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004F2EB0 PDK1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 PDK1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000007F792 PDK1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 PDK1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001CC4BD PDK1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 PDK1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004407DC PDK1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000B0E50 PDK1 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ABL1 PDK1 22135298 phosphorylation N/A PhosphoSite
PGK1 PDK1 22135298 phosphorylation N/A PhosphoSite
JAK2 PDK1 22135298 phosphorylation N/A PhosphoSite
FGFR1 PDK1 22135298 phosphorylation N/A PhosphoSite
PDK1 PDHA1 22135298 phosphorylation N/A PhosphoSite
PDK1 PDHA2 22135298 phosphorylation N/A PhosphoSite
AKT2 PDK1 22135298 phosphorylation N/A PhosphoSite
FLT3 PDK1 22135298 phosphorylation N/A PhosphoSite
AKT1 PDK1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
ATP5PO PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX5B PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATPAF2 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATP5F1B PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFAF3 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL28 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPS6 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRM3 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL27 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL40 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SUPV3L1 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COL4A5 PDK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HIF1A PDK1 25348397 N/A physical interaction ComPPI
KAT2B PDK1 25348397 N/A physical interaction ComPPI
PKN1 PDK1 25348397 N/A physical interaction ComPPI
PKN2 PDK1 17110931 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
DUT PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DAP3 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PIK3CA PDK1 25348397 N/A physical interaction ComPPI
ITGB3 PDK1 25348397 N/A physical interaction ComPPI
NECTIN3 PDK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SSBP1 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
POLG PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
POLDIP2 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CBFA2T3 PDK1 25348397 N/A physical interaction ComPPI
XRCC6 PDK1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDP1 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDHB PDK1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PDHX PDK1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PDHA1 PDK1 11485553 11486000 12676647 14525934 24234451 25348397 29568061 7782287 phosphorylation reaction,association experimental interaction detection,physical interaction,enzymatic study,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct
RIMS1 PDK1 25348397 N/A physical interaction ComPPI
YWHAQ PDK1 14525934 19010391 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
USP4 PDK1 22347420 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RPS6KB1 PDK1 11279232 14525934 17110931 24234451 25348397 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
STXBP2 PDK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TSFM PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ACAA2 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
EGFR PDK1 25348397 N/A physical interaction ComPPI
TNK2 PDK1 25348397 N/A physical interaction ComPPI
PDK2 PDK1 12573248 14525934 24234451 25348397 26496610 29568061 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct
DLAT PDK1 11978179 14525934 24234451 25348397 29568061 association experimental interaction detection,physical interaction,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct
BCKDHB PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BCKDHA PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
IDH3A PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
IDH3B PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
LRPPRC PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
APLNR PDK1 25348397 N/A physical interaction ComPPI
TIMM13 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SUCLG2 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SUCLA2 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TIMM44 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 RALGDS 25348397 N/A physical interaction ComPPI
PDK1 RPTOR 25348397 N/A physical interaction ComPPI
PDK1 SGK1 25348397 N/A physical interaction ComPPI
PDK1 LAMTOR5 25348397 N/A physical interaction ComPPI
PDK1 HLA-DPA1 25348397 N/A physical interaction ComPPI
PDK1 HLA-B 25348397 N/A physical interaction ComPPI
PDK1 PDK3 24234451 25348397 26496610 29568061 association anti tag coimmunoprecipitation,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PDK1 OXLD1 25348397 N/A physical interaction ComPPI
PDK1 MTOR 25348397 N/A physical interaction ComPPI
PDK1 HMGN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDK1 CCDC93 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDK1 SPG7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDK1 MKNK1 25348397 N/A physical interaction ComPPI
PDK1 CELF2 25348397 N/A physical interaction ComPPI
PDK1 SRCAP 25348397 N/A physical interaction ComPPI
PDK1 RASSF8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDK1 VWA8 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PDK1 COG4 25348397 N/A physical interaction ComPPI
PDK1 PYCR2 24234451 25348397 26496610 29568061 association anti tag coimmunoprecipitation,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PDK1 NSFL1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDK1 ZNFX1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDK1 VKORC1 25348397 N/A physical interaction ComPPI
PDK1 ILKAP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDK1 TRIM47 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDK1 ATG4A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDK1 NRBP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDK1 FOXD4 25348397 N/A physical interaction ComPPI
PDK1 PDK4 25348397 N/A physical interaction ComPPI
PDK1 CRBN 25348397 N/A physical interaction ComPPI
PDK1 NDUFS7 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PDK1 ACAD9 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PDK1 SLC18A1 25348397 N/A physical interaction ComPPI
PDK1 LAMP3 25348397 N/A physical interaction ComPPI
PDK1 DENR 25348397 N/A physical interaction ComPPI
PDK1 ARNT 25348397 N/A physical interaction ComPPI
PDK1 SGK3 16888620 24234451 25348397 phosphorylation reaction,colocalization fluorescence microscopy,protein kinase assay ComPPI,IntAct
PDK1 EPAS1 17024177 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PDK1 MRPS18A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL32 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 HINT2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 SPRYD4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL50 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 THEM4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL42 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NFS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS18B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 AFG3L2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS16 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFAF1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ACOT9 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS7 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS33 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 AK3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFA12 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 WARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MTRF1L 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 AASS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL39 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 OXSM 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 UQCC1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ABHD10 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 SIRT3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 IARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS30 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 SARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 LYRM4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL47 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 CARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NT5DC2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL46 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PPA2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ISCU 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 QRSL1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 SLIRP 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL37 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS26 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL13 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 TARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ISCA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 C17ORF80 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 TACO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 UQCC2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL45 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MGME1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ELAC2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ACO2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 HSD17B10 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 GFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PYURF 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 DHTKD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 FMC1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PTCD3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS24 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL38 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL24 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 GTPBP3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS31 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS27 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 HSD17B8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 RTN4IP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PNPT1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 FLAD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PDPR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL43 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 GUF1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFAF2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 THNSL1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL41 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NT5DC3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ACOT1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 GLRX5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL10 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 TRMT11 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL21 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFAF7 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 TRMT10C 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 HSDL2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MTHFD1L 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 DARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 C8ORF82 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 HIBCH 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PDE12 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 LYPLAL1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ANGEL2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 LYRM7 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFAF5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ATPAF1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 IBA57 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 VARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 AARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 COQ5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PREPL 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 TRMT5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFA9 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 HAGH 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 CLPP 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFA5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 KARS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 LARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL58 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL49 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 GRSF1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PMPCA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 OGDH 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS9 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS34 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS11 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS36 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS35 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS10 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS25 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS22 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFA6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 OXCT1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 SUCLG1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL12 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFV1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ACOT2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ACADVL 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 HARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MTIF2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ACADSB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 HADHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ETFB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 DLST 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 LONP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ATP5F1C 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 SHMT2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PYCR1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 SDHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ALDH1B1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PPIF 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ECHS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ATP5F1D 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PRDX3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 GATD3B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ALDH4A1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 AK4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ACAT1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ATP5PB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ME2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MMUT 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 SDHB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFV2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ATP5PF 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MTHFD2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ETFA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ALAS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ACADM 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPL3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ALDH2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 OAT 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 GLUD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 LETM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFA7 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 GLS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 CLPX 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ATP5PD 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 GATB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ERAL1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 ECI2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFS3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PMPCB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFS6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 PTCD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 MRPS14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFS5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NRDC 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFA2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NDUFS4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NME4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PDK1 NUDT19 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MYH1 PDK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MMAB PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL44 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ECH1 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
THG1L PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL4 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MALSU1 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
YARS2 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ALDH18A1 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL53 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TRMT61B PDK1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MRPS23 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL1 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL15 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GATC PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HSCB PDK1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
BETATUB60D PDK1 25348397 N/A physical interaction ComPPI
14-3-3EPSILON PDK1 25348397 N/A two hybrid,two hybrid,physical interaction ComPPI
RPLP1 PDK1 25348397 N/A physical interaction ComPPI
RPL18A PDK1 25348397 N/A physical interaction ComPPI
MST57DA PDK1 25348397 N/A two hybrid,two hybrid,physical interaction,physical interaction ComPPI
EIF3M PDK1 25348397 N/A physical interaction ComPPI
RACK1 PDK1 25348397 N/A physical interaction ComPPI
NUP98-96 PDK1 25348397 N/A physical interaction ComPPI
RPT2 PDK1 25348397 N/A physical interaction ComPPI
AKT1 PDK1 24234451 25348397 physical association experimental interaction detection ComPPI,IntAct
RPS9 PDK1 25348397 N/A physical interaction ComPPI
AKAP200 PDK1 25348397 N/A physical interaction ComPPI
CKIALPHA PDK1 25348397 N/A physical interaction ComPPI
RPL28 PDK1 25348397 N/A physical interaction ComPPI
RPL10 PDK1 25348397 N/A physical interaction ComPPI
MAHJ PDK1 25348397 N/A physical interaction ComPPI
SHV PDK1 25348397 N/A physical interaction ComPPI
RPS17 PDK1 25348397 N/A physical interaction ComPPI
RPT6 PDK1 25348397 N/A physical interaction ComPPI
RPS15AA PDK1 25348397 N/A physical interaction ComPPI
CHC PDK1 25348397 N/A physical interaction ComPPI
BOCKS PDK1 25348397 N/A anti tag coimmunoprecipitation ComPPI
NUP50 PDK1 25348397 N/A physical interaction ComPPI
EIF3C PDK1 25348397 N/A physical interaction ComPPI
PSC PDK1 25348397 N/A anti tag coimmunoprecipitation ComPPI
RPS7 PDK1 25348397 N/A physical interaction ComPPI
RM62 PDK1 25348397 N/A physical interaction ComPPI
KCMF1 PDK1 25348397 N/A physical interaction ComPPI
RPL31 PDK1 25348397 N/A physical interaction ComPPI
MASK PDK1 25348397 N/A physical interaction ComPPI
SAM-S PDK1 25348397 N/A physical interaction ComPPI
EIF3A PDK1 25348397 N/A physical interaction ComPPI
RPL9 PDK1 25348397 N/A physical interaction ComPPI
NCD PDK1 25348397 N/A physical interaction ComPPI
CLU PDK1 25348397 N/A physical interaction ComPPI
L(2)TID PDK1 25348397 N/A physical interaction ComPPI
EIF4A PDK1 25348397 N/A physical interaction ComPPI
ACT57B PDK1 25348397 N/A physical interaction ComPPI
GNF1 PDK1 25348397 N/A physical interaction ComPPI
PDK1 PP2A-29B 25348397 N/A physical interaction ComPPI
PDK1 RPS6 25348397 N/A physical interaction ComPPI
PDK1 HSC70-3 25348397 N/A physical interaction ComPPI
PDK1 EIF2ALPHA 25348397 N/A physical interaction ComPPI
PDK1 EIF3I 25348397 N/A physical interaction ComPPI
PDK1 RPS26 25348397 N/A physical interaction ComPPI
PDK1 RPS11 25348397 N/A physical interaction ComPPI
PDK1 RPS23 25348397 N/A physical interaction ComPPI
PDK1 RPS16 25348397 N/A physical interaction ComPPI
PDK1 FIB 25348397 N/A physical interaction ComPPI
PDK1 AGO2 25348397 N/A physical interaction ComPPI
PDK1 RPL13A 25348397 N/A physical interaction ComPPI
PDK1 SQD 25348397 N/A physical interaction ComPPI
PDK1 SERCA 25348397 N/A physical interaction ComPPI
PDK1 LARP 25348397 N/A physical interaction ComPPI
PDK1 PDK1 17683942 24234451 N/A x-ray crystallography IntAct
SRC PDK1 18616680 27898060 N/A N/A OmniPath
PRKCA PDK1 12177059 27898060 N/A N/A OmniPath
FGFR1 PDK1 22195962 27898060 stimulant N/A OmniPath
PDK1 AKT1 11278835 16341064 27898060 9512493 stimulant N/A OmniPath
PDK1 PRKCG 17053865 27898060 stimulant N/A OmniPath
PDK1 PAK1 10995762 27898060 stimulant N/A OmniPath
PDK1 SGK1 17684529 27898060 stimulant N/A OmniPath
PDK1 AKT2 27898060 9512493 stimulant N/A OmniPath
PDK1 PKN2 10753910 17110931 18669648 18835241 27898060 stimulant N/A OmniPath
PDK1 RPS6KB1 11279232 16286006 17110931 18669648 20068231 27898060 stimulant N/A OmniPath
PDK1 ITGB3 10896934 18578522 27898060 N/A N/A OmniPath
PDK1 PDHA2 16436377 27898060 inhibition N/A OmniPath
PDK1 PDHA1 11485553 11486000 12676647 15302935 16436377 18088087 18212344 18691976 18767875 19415658 20058876 20068231 20166139 27898060 7782287 inhibition N/A OmniPath

Visualization










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