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GENE：PFKP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PFKP
FullNmae phosphofructokinase, platelet
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8878
EnsembleID ENSG00000067057
Uniprot Q01813

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PFKP cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PFKP GO:0003872,GO:0003872,GO:0003872,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005945,GO:0006002,GO:0016020,GO:0016020,GO:0016208,GO:0016310,GO:0030388,GO:0042802,GO:0044877,GO:0045296,GO:0046872,GO:0048029,GO:0061621,GO:0070062,GO:0070095,GO:1990830

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PFKP hsa:5214 path:hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human)
PFKP hsa:5214 path:hsa00030 Pentose phosphate pathway - Homo sapiens (human)
PFKP hsa:5214 path:hsa00051 Fructose and mannose metabolism - Homo sapiens (human)
PFKP hsa:5214 path:hsa00052 Galactose metabolism - Homo sapiens (human)
PFKP hsa:5214 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PFKP hsa:5214 path:hsa01200 Carbon metabolism - Homo sapiens (human)
PFKP hsa:5214 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)
PFKP hsa:5214 path:hsa03018 RNA degradation - Homo sapiens (human)
PFKP hsa:5214 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
PFKP hsa:5214 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
PFKP hsa:5214 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
PFKP hsa:5214 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
PFKP hsa:5214 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PFKP 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 PFKP 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PFKP 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PFKP 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PFKP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
KLF4 PFKP 21586797 trascriptional regulation,stimulation inferred by curator TFlink
ZBTB7A PFKP 25184678 trascriptional regulation,stimulation inferred by curator TFlink
SP3 PFKP N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 PFKP 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000AD002 PFKP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 PFKP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 PFKP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA PFKP 20371350 21572407 22012620 22473208 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F PFKP 20371350 21572407 22012620 22473208 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 PFKP 20371350 21572407 22012620 22473208 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 PFKP 20371350 21572407 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA PFKP 20371350 21572407 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 PFKP 20371350 21572407 22012620 22473208 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 PFKP 20371350 21572407 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 PFKP 20371350 21572407 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C PFKP 20371350 21572407 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 PFKP 20371350 21572407 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 PFKP 20371350 21572407 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 PFKP 20371350 21572407 22012620 22473208 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PFKP 20371350 21572407 22012620 22473208 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 PFKP 20371350 21572407 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA PFKP 20371350 21572407 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B PFKP 20371350 21572407 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003BD367 PFKP 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TXLNA PFKP 25348397 N/A physical interaction ComPPI
SNW1 PFKP 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L PFKP 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNLL1 PFKP 14525934 14760703 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPIB PFKP 25348397 N/A physical interaction ComPPI
OXSR1 PFKP 25348397 N/A physical interaction ComPPI
PCBP1 PFKP 25348397 N/A physical interaction ComPPI
NUTF2 PFKP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRAF6 PFKP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GABARAPL2 PFKP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CCDC22 PFKP 25348397 N/A physical interaction ComPPI
PTPN6 PFKP 25348397 N/A physical interaction ComPPI
KEAP1 PFKP 25348397 N/A physical interaction ComPPI
MCM2 PFKP 25348397 N/A physical interaction ComPPI
CD81 PFKP 25348397 N/A physical interaction ComPPI
COPS5 PFKP 25348397 N/A physical interaction ComPPI
ARHGDIA PFKP 25348397 N/A physical interaction ComPPI
ARHGAP1 PFKP 25348397 N/A physical interaction ComPPI
CUL3 PFKP 25348397 N/A physical interaction ComPPI
YWHAZ PFKP 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
PFKP MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PFKP DMWD 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PFKP WIPI2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PFKP SIRT7 25348397 N/A physical interaction ComPPI
PFKP PARD3 25348397 N/A physical interaction ComPPI
PFKP FBXO25 25348397 N/A physical interaction ComPPI
PFKP TERF1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PFKP TINF2 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PFKP ACD 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PFKP POT1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PFKP PFKL 25348397 N/A physical interaction ComPPI
PFKP PFKM 25348397 N/A physical interaction ComPPI
PFKP TMPO 25348397 N/A physical interaction ComPPI
PFKP TMPO 25348397 N/A physical interaction ComPPI
PFKP EPRS1 25348397 N/A physical interaction ComPPI
PFKP FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PFKP ITGA4 25348397 N/A physical interaction ComPPI
PFKP HDAC6 25348397 N/A physical interaction ComPPI
PFKP EGFR 25348397 N/A physical interaction ComPPI
PFKP WNK1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PFKP AGO2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PFKP FBXO6 25348397 N/A physical interaction ComPPI
PFKP EEF1A1 25348397 N/A physical interaction ComPPI
PFKP TUBB4B 25348397 N/A physical interaction ComPPI
PFKP ILK 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PFKP CUL7 25348397 N/A physical interaction ComPPI
PFKP FAF2 25348397 N/A physical interaction ComPPI
PFKP ARFIP1 25348397 N/A physical interaction ComPPI
PFKP DNAJC9 25348397 N/A physical interaction ComPPI
PFKP MCMBP 25348397 N/A physical interaction ComPPI
PFKP MTHFD1 25348397 N/A physical interaction ComPPI
PFKP NMD3 25348397 N/A physical interaction ComPPI
PFKP ELAC2 25348397 N/A physical interaction ComPPI
PFKP FUS 25348397 N/A physical interaction ComPPI
PFKP PYGL 25348397 N/A physical interaction ComPPI
PFKP RSU1 25348397 N/A physical interaction ComPPI
PFKP PLCG1 25348397 N/A physical interaction ComPPI
PFKP NTRK1 25348397 N/A physical interaction ComPPI
PFKP SKI 25348397 N/A physical interaction ComPPI
PFKP SENP3 25348397 N/A physical interaction ComPPI
PFKP CDH1 25348397 N/A physical interaction ComPPI
PFKP IFT122 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
PFKP WDR19 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
PFKP TRIM25 25348397 N/A physical interaction ComPPI
PFKP BRCA1 25348397 N/A physical interaction ComPPI
PFKP YAP1 25348397 N/A physical interaction ComPPI
PFKP TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PFKP ARF6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PFKP BCAR3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PFKP HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PFKP PRKAB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PFKP MAX 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PFKP VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
PFKP LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
PFKP NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
PFKP TUBA1A 24234451 25348397 29568061 association pull down ComPPI,IntAct
PFKP TGOLN2 24234451 25348397 29568061 association pull down ComPPI,IntAct
PKM PFKP 25348397 N/A physical interaction ComPPI
SOX2 PFKP 25348397 N/A physical interaction ComPPI
SMARCB1 PFKP 24234451 30108113 association pull down,proximity-dependent biotin identification IntAct
STK38L PFKP 24234451 30108113 association pull down IntAct

Visualization










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