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GENE：POLD1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLD1
FullNmae DNA polymerase delta 1, catalytic subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9175
EnsembleID ENSG00000062822
Uniprot P28340

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLD1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLD1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLD1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLD1 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
POLD1 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
POLD1 GO:0000109,GO:0000166,GO:0000731,GO:0000731,GO:0000781,GO:0003677,GO:0003682,GO:0003684,GO:0003887,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005829,GO:0006260,GO:0006261,GO:0006261,GO:0006281,GO:0006287,GO:0006287,GO:0006297,GO:0006297,GO:0006297,GO:0008296,GO:0009411,GO:0016020,GO:0016235,GO:0019899,GO:0034644,GO:0043625,GO:0043625,GO:0043625,GO:0045004,GO:0046872,GO:0051539,GO:0055089,GO:0070987,GO:0071897

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLD1 hsa:5424 path:hsa03030 DNA replication - Homo sapiens (human)
POLD1 hsa:5424 path:hsa03410 Base excision repair - Homo sapiens (human)
POLD1 hsa:5424 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
POLD1 hsa:5424 path:hsa03430 Mismatch repair - Homo sapiens (human)
POLD1 hsa:5424 path:hsa03440 Homologous recombination - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PCNA POLD1 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 26192618 interaction type N/A ACSN
POLD1 POLD3 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 26192618 27760120 27760777 interaction type N/A ACSN
POLD4 POLD1 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 26192618 27760120 27760777 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
E2F4 POLD1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 POLD1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 POLD1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF POLD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 POLD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 POLD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A POLD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 POLD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 POLD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 POLD1 11375983 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 POLD1 11375983 trascriptional regulation,stimulation inferred by curator TFlink
TP53 POLD1 11375983 trascriptional regulation,stimulation inferred by curator TFlink
NFIC POLD1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A POLD1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 POLD1 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 POLD1 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000005481D POLD1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 POLD1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
MSH2 POLD1 25361965 interaction type N/A PTMCode2
POLD1 MSH2 25361965 interaction type N/A PTMCode2
POLD1 POLD3 25361965 interaction type N/A PTMCode2
POLD3 POLD1 25361965 interaction type N/A PTMCode2
POLD1 MCM2 25361965 interaction type N/A PTMCode2
MCM2 POLD1 25361965 interaction type N/A PTMCode2
POLD1 CDK2 25361965 interaction type N/A PTMCode2
CDK2 POLD1 25361965 interaction type N/A PTMCode2
POLD1 RFC4 25361965 interaction type N/A PTMCode2
RFC4 POLD1 25361965 interaction type N/A PTMCode2
POLD1 MGMT 25361965 interaction type N/A PTMCode2
MGMT POLD1 25361965 interaction type N/A PTMCode2
POLD1 FEN1 25361965 interaction type N/A PTMCode2
FEN1 POLD1 25361965 interaction type N/A PTMCode2
POLD1 POLD4 25361965 interaction type N/A PTMCode2
POLD4 POLD1 25361965 interaction type N/A PTMCode2
POLD1 POLE 25361965 interaction type N/A PTMCode2
POLE POLD1 25361965 interaction type N/A PTMCode2
POLD1 POLA1 25361965 interaction type N/A PTMCode2
POLA1 POLD1 25361965 interaction type N/A PTMCode2
POLD1 PCNA 25361965 interaction type N/A PTMCode2
PCNA POLD1 25361965 interaction type N/A PTMCode2
POLD1 WRNIP1 25361965 interaction type N/A PTMCode2
WRNIP1 POLD1 25361965 interaction type N/A PTMCode2
POLD1 ERCC2 25361965 interaction type N/A PTMCode2
ERCC2 POLD1 25361965 interaction type N/A PTMCode2
POLD1 POLD2 25361965 interaction type N/A PTMCode2
POLD2 POLD1 25361965 interaction type N/A PTMCode2
POLD1 RFC5 25361965 interaction type N/A PTMCode2
RFC5 POLD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MFAP1 POLD1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SNW1 POLD1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L POLD1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 POLD1 24234451 25348397 28178521 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO2B POLD1 24234451 25348397 28178521 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PCNA POLD1 12171929 12403614 14525934 15805117 16510448 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,far western blotting,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MAGEA6 POLD1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GABARAPL2 POLD1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MYH7 POLD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DDX20 POLD1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SRC POLD1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
ATR POLD1 25348397 N/A physical interaction ComPPI
GRB2 POLD1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
DHX9 POLD1 25348397 N/A physical interaction ComPPI
COPS5 POLD1 25348397 N/A physical interaction ComPPI
CUL3 POLD1 25348397 N/A physical interaction ComPPI
NTRK1 POLD1 25348397 N/A physical interaction ComPPI
XRCC1 POLD1 25348397 N/A physical interaction ComPPI
XRCC5 POLD1 12393188 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RBM14 POLD1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPA1 POLD1 25348397 N/A physical interaction ComPPI
POLD3 POLD1 10852724 12403614 14525934 16510448 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,molecular sieving,chromatography technology,physical interaction,ion exchange chromatography,in vivo ComPPI,HPRD,IntAct
POLD2 POLD1 12403614 16510448 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,molecular sieving,chromatography technology,pull down,physical interaction,ion exchange chromatography ComPPI,IntAct
MYC POLD1 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CD247 POLD1 24234451 24502978 25348397 association pull down ComPPI,IntAct
MAPK6 POLD1 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP2R5C POLD1 25348397 N/A physical interaction ComPPI
XPO1 POLD1 25348397 N/A physical interaction ComPPI
RPA2 POLD1 25348397 N/A physical interaction ComPPI
RPA3 POLD1 25348397 N/A physical interaction ComPPI
TRIP10 POLD1 25348397 N/A physical interaction ComPPI
UPF2 POLD1 25348397 N/A physical interaction ComPPI
ARF6 POLD1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDK2 POLD1 14525934 25348397 9545286 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CUL1 POLD1 25348397 N/A physical interaction ComPPI
WRNIP1 POLD1 14525934 15670210 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
POLD1 TREX2 12806015 25348397 27898060 N/A in vitro ComPPI,OmniPath
POLD1 CHGB 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLD1 CEP126 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
POLD1 PTP4A3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
POLD1 NCAPG 25348397 N/A physical interaction ComPPI
POLD1 UPF1 25348397 N/A physical interaction ComPPI
POLD1 MGMT 25348397 N/A physical interaction ComPPI
POLD1 TERF2 25348397 N/A physical interaction ComPPI
POLD1 ERCC6 25348397 N/A physical interaction ComPPI
POLD1 ERCC6 25348397 N/A physical interaction ComPPI
POLD1 POLK 25348397 N/A physical interaction ComPPI
POLD1 PIDD1 25348397 N/A physical interaction ComPPI
POLD1 GINS4 25348397 N/A physical interaction ComPPI
POLD1 TERF2IP 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
POLD1 COPS6 25348397 N/A physical interaction ComPPI
POLD1 MCM3 25348397 N/A physical interaction ComPPI
POLD1 PURB 25348397 N/A physical interaction ComPPI
POLD1 CDK4 25348397 N/A physical interaction ComPPI
POLD1 CCND3 25348397 N/A physical interaction ComPPI
POLD1 CCNE1 25348397 N/A physical interaction ComPPI
POLD1 MMS19 24234451 25348397 28178521 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLD1 POLD4 12403614 16510448 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,molecular sieving,chromatography technology,pull down,physical interaction,ion exchange chromatography ComPPI,IntAct
POLD1 TSEN2 25348397 N/A physical interaction ComPPI
POLD1 WASF2 25348397 N/A physical interaction ComPPI
POLD1 TBC1D2 25348397 N/A physical interaction ComPPI
POLD1 TBC1D4 25348397 N/A physical interaction ComPPI
POLD1 WDR44 25348397 N/A physical interaction ComPPI
POLD1 SPRTN 25348397 N/A physical interaction ComPPI
POLD1 RNF2 25348397 N/A physical interaction ComPPI
POLD1 GFOD1 25348397 N/A physical interaction ComPPI
POLD1 ARHGAP25 25348397 N/A physical interaction ComPPI
POLD1 CNOT2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLD1 USP43 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLD1 GAR1 25348397 N/A physical interaction ComPPI
POLD1 CEP192 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLD1 YOD1 25348397 N/A physical interaction ComPPI
POLD1 CRTC3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLD1 RNF126 25348397 N/A physical interaction ComPPI
POLD1 ZNF746 25348397 N/A physical interaction ComPPI
POLD1 EAF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
POLD1 AP3B1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
POLD1 NAF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
POLD1 EIF2AK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
POLD1 ATRX 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
POLD1 NOLC1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
POLD1 MCPH1 25348397 N/A physical interaction ComPPI
POLD1 GSTK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
POLD1 ABL1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
POLD1 FYN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
POLD1 CDC45 23910567 24234451 25348397 association pull down ComPPI,IntAct
POLD1 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
POLD1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
POLD1 CAT 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
POLD1 BRCA1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
POLD1 MDC1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
HSCB POLD1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
POLD1 HAUS7 12806015 14525934 N/A experimental interaction detection HPRD
METTL3 POLD1 24234451 29507755 association anti tag coimmunoprecipitation IntAct

Visualization










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