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GENE：POLE

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLE
FullNmae DNA polymerase epsilon, catalytic subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9177
EnsembleID ENSG00000177084
Uniprot Q07864

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLE mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLE cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes
POLE cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
POLE GO:0000082,GO:0000166,GO:0000278,GO:0000731,GO:0003677,GO:0003677,GO:0003682,GO:0003887,GO:0003887,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005886,GO:0006260,GO:0006261,GO:0006272,GO:0006287,GO:0006287,GO:0006297,GO:0006297,GO:0008270,GO:0008310,GO:0008622,GO:0008622,GO:0008622,GO:0045004,GO:0048568,GO:0051539

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLE hsa:5426 path:hsa03030 DNA replication - Homo sapiens (human)
POLE hsa:5426 path:hsa03410 Base excision repair - Homo sapiens (human)
POLE hsa:5426 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PCNA POLE 10858306 11756412 11900249 11948190 12637553 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16442856 16697054 17088286 17116881 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19208614 19258535 19364882 1974050 19748837 19772495 19793801 19809470 19847258 20211143 20227374 20478261 20510258 20603072 21251944 21270334 21282463 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506 26192618 8264637 8978692 interaction type N/A ACSN
POLE POLK 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 26192618 8264637 8978692 interaction type N/A ACSN
RPA2 POLE 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 26192618 8264637 8978692 interaction type N/A ACSN
XRCC1 POLE 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 26192618 8264637 8978692 interaction type N/A ACSN
PARP1 POLE 10858306 11756412 11948190 12637553 14624239 14726013 15703371 16442856 16697054 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506 26192618 interaction type N/A ACSN
POLB POLE 10858306 11756412 11948190 12637553 14624239 14726013 15703371 16442856 16697054 17088286 17116881 18087292 18584027 18809224 19208614 19364882 1974050 19748837 19772495 19847258 20478261 20510258 20603072 21251944 21270334 21376743 22021614 22055391 22469522 22713970 22743550 22921416 23145148 23414611 23562323 23568489 24050180 24210699 24684389 24976506 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ESR1 POLE 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 POLE 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 POLE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF POLE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 POLE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 POLE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A POLE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 POLE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 POLE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 POLE 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 POLE 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS000005481D POLE 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 POLE 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 POLE 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004AC389 POLE 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001BCAC5 POLE 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 POLE 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000072B4C8 POLE 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000355E82 POLE 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001012BC POLE 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FEN1 POLE 25361965 interaction type N/A PTMCode2
POLE FEN1 25361965 interaction type N/A PTMCode2
POLE POLE3 25361965 interaction type N/A PTMCode2
POLE3 POLE 25361965 interaction type N/A PTMCode2
POLE POLA1 25361965 interaction type N/A PTMCode2
POLA1 POLE 25361965 interaction type N/A PTMCode2
POLE PCNA 25361965 interaction type N/A PTMCode2
PCNA POLE 25361965 interaction type N/A PTMCode2
POLE RFC5 25361965 interaction type N/A PTMCode2
RFC5 POLE 25361965 interaction type N/A PTMCode2
POLE POLE4 25361965 interaction type N/A PTMCode2
POLE4 POLE 25361965 interaction type N/A PTMCode2
RFC4 POLE 25361965 interaction type N/A PTMCode2
POLE RFC4 25361965 interaction type N/A PTMCode2
POLD1 POLE 25361965 interaction type N/A PTMCode2
POLE POLD1 25361965 interaction type N/A PTMCode2
POLE2 POLE 25361965 interaction type N/A PTMCode2
POLE POLE2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 POLE 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CIAO1 POLE 25348397 N/A physical interaction ComPPI
HSPA8 POLE 25348397 N/A physical interaction ComPPI
CIAO2B POLE 25348397 N/A physical interaction ComPPI
PCNA POLE 12171929 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
POLE4 POLE 10801849 14525934 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
FOXB1 POLE 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
POLE3 POLE 10801849 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOXG1 POLE 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
EIF4G1 POLE 25348397 N/A physical interaction ComPPI
POLA1 POLE 14525934 25348397 9563011 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PSMD11 POLE 25348397 N/A physical interaction ComPPI
PEX19 POLE 25348397 N/A physical interaction ComPPI
NTRK1 POLE 25348397 N/A physical interaction ComPPI
XRCC5 POLE 12393188 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
POLE STK19 14525934 14667819 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
POLE RAD17 14500819 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
POLE MDM2 10982879 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,OmniPath
POLE MYC 17314511 17353931 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
POLE TOPBP1 11395493 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD
POLE SIRT7 25348397 N/A physical interaction ComPPI
POLE POLE2 10801849 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
POLE POLD4 25348397 N/A physical interaction ComPPI
POLE GINS4 25348397 N/A physical interaction ComPPI
POLE PRIM1 25348397 N/A physical interaction ComPPI
POLE MMS19 25348397 N/A physical interaction ComPPI
POLE CIAO2A 25348397 N/A physical interaction ComPPI
POLE DTWD2 25348397 N/A physical interaction ComPPI
POLE LRRC46 25348397 N/A physical interaction ComPPI
POLE TGOLN2 25348397 N/A physical interaction ComPPI
POLE FBXW11 25348397 N/A physical interaction ComPPI
POLE MSH6 25348397 N/A physical interaction ComPPI
POLE PABPC1 25348397 N/A physical interaction ComPPI
POLE PABPC4 25348397 N/A physical interaction ComPPI
POLE PSMD4 25348397 N/A physical interaction ComPPI
POLE SMC1A 25348397 N/A physical interaction ComPPI
POLE SSB 25348397 N/A physical interaction ComPPI
POLE FOXE1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
POLE FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
POLE FOXQ1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
POLE BMERB1 25348397 N/A physical interaction ComPPI
POLE LGALS3BP 25348397 N/A physical interaction ComPPI
POLE DNAJC7 25348397 N/A physical interaction ComPPI
POLE RPL28 25348397 N/A physical interaction ComPPI
POLE DKKL1 25348397 N/A physical interaction ComPPI
POLE ZBBX 25348397 N/A physical interaction ComPPI
POLE LYPD4 25348397 N/A physical interaction ComPPI
POLE ZUP1 25348397 N/A physical interaction ComPPI
POLE KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
POLE LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
POLE RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
POLE BRCA1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
POLE UHRF1BP1 24234451 30021884 physical association cross-linking study IntAct

Visualization










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