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GENE：POLG

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLG
FullNmae DNA polymerase gamma, catalytic subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9179
EnsembleID ENSG00000140521
Uniprot P54098

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLG cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
POLG GO:0002020,GO:0003677,GO:0003682,GO:0003887,GO:0003887,GO:0003887,GO:0005515,GO:0005739,GO:0005739,GO:0005759,GO:0005760,GO:0005760,GO:0006259,GO:0006261,GO:0006264,GO:0006264,GO:0006264,GO:0006287,GO:0008408,GO:0008408,GO:0008408,GO:0032991,GO:0042645,GO:0043231,GO:0071897

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLG hsa:5428 path:hsa03410 Base excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 POLG 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 POLG 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 POLG 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
AR POLG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 POLG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA POLG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF POLG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 POLG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 POLG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 POLG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 POLG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS POLG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A POLG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 POLG 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 POLG 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001C3AC1 POLG 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 POLG 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE POLG 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000170CF4 POLG 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000075BDA4 POLG 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004D84DB POLG 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004505E4 POLG 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000017EA6A POLG 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 POLG 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC POLG 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004407DC POLG 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 POLG 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D POLG 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D793 POLG 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000007340 POLG 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000057FDB8 POLG 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SSBP1 POLG 10827171 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
POLG NFATC2 25348397 N/A physical interaction ComPPI
POLG OTC 25348397 N/A physical interaction ComPPI
POLG NDUFS7 25348397 N/A physical interaction ComPPI
POLG SDHB 25348397 N/A physical interaction ComPPI
POLG HNRNPL 25348397 N/A physical interaction ComPPI
POLG MYC 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
POLG E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
POLG HSPD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
POLG PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL4 POLG 25348397 N/A physical interaction ComPPI
TRMT61B POLG 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
POLG DNAJA3 16327803 27898060 N/A N/A OmniPath

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