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GENE：POLR2B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLR2B
FullNmae RNA polymerase II subunit B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9188
EnsembleID ENSG00000047315
Uniprot P30876

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLR2B cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
POLR2B GO:0000781,GO:0001055,GO:0001055,GO:0003677,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005665,GO:0005665,GO:0006366,GO:0016020,GO:0032549,GO:0046872

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLR2B hsa:5431 path:hsa03020 RNA polymerase - Homo sapiens (human)
POLR2B hsa:5431 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
POLR2B hsa:5431 path:hsa05016 Huntington disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
POLR2B YTHDC2 23180781 24269672 physical association anti tag coimmunoprecipitation InnateDB
RNF2 POLR2B 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR POLR2B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 POLR2B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 POLR2B 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 POLR2B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 POLR2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF POLR2B 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 POLR2B 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000AD002 POLR2B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 POLR2B 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
POLR2J POLR2B 25361965 interaction type N/A PTMCode2
POLR2B POLR2J 25361965 interaction type N/A PTMCode2
SUPT4H1 POLR2B 25361965 interaction type N/A PTMCode2
POLR2B SUPT4H1 25361965 interaction type N/A PTMCode2
RPAP1 POLR2B 25361965 interaction type N/A PTMCode2
POLR2B RPAP1 25361965 interaction type N/A PTMCode2
POLR2B POLR2L 25361965 interaction type N/A PTMCode2
POLR2L POLR2B 25361965 interaction type N/A PTMCode2
POLR2B GTF2E2 25361965 interaction type N/A PTMCode2
GTF2E2 POLR2B 25361965 interaction type N/A PTMCode2
POLR2B GTF2B 25361965 interaction type N/A PTMCode2
GTF2B POLR2B 25361965 interaction type N/A PTMCode2
POLR2B POLR3A 25361965 interaction type N/A PTMCode2
POLR3A POLR2B 25361965 interaction type N/A PTMCode2
POLR2B POLR3F 25361965 interaction type N/A PTMCode2
POLR3F POLR2B 25361965 interaction type N/A PTMCode2
POLR2B SUPT5H 25361965 interaction type N/A PTMCode2
SUPT5H POLR2B 25361965 interaction type N/A PTMCode2
POLR2B BTF3 25361965 interaction type N/A PTMCode2
BTF3 POLR2B 25361965 interaction type N/A PTMCode2
POLR2B GTF2F1 25361965 interaction type N/A PTMCode2
GTF2F1 POLR2B 25361965 interaction type N/A PTMCode2
POLR2B POLR2F 25361965 interaction type N/A PTMCode2
POLR2F POLR2B 25361965 interaction type N/A PTMCode2
POLR2D POLR2B 25361965 interaction type N/A PTMCode2
POLR2B POLR2D 25361965 interaction type N/A PTMCode2
GPN1 POLR2B 25361965 interaction type N/A PTMCode2
POLR2B GPN1 25361965 interaction type N/A PTMCode2
POLR2E POLR2B 25361965 interaction type N/A PTMCode2
POLR2B POLR2E 25361965 interaction type N/A PTMCode2
POLR2C POLR2B 25361965 interaction type N/A PTMCode2
POLR2B POLR2C 25361965 interaction type N/A PTMCode2
POLR2I POLR2B 25361965 interaction type N/A PTMCode2
POLR2B POLR2I 25361965 interaction type N/A PTMCode2
CTDP1 POLR2B 25361965 interaction type N/A PTMCode2
POLR2B CTDP1 25361965 interaction type N/A PTMCode2
POLR2G POLR2B 25361965 interaction type N/A PTMCode2
POLR2B POLR2G 25361965 interaction type N/A PTMCode2
TAF10 POLR2B 25361965 interaction type N/A PTMCode2
POLR2B TAF10 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CCNH POLR2B 25348397 N/A physical interaction ComPPI
CUL5 POLR2B 25348397 N/A physical interaction ComPPI
HSPA8 POLR2B 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
POLR2L POLR2B 14525934 25348397 9201987 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BTF3 POLR2B 14525934 2320128 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TUBB POLR2B 25348397 N/A physical interaction ComPPI
VCP POLR2B 25348397 N/A physical interaction ComPPI
CALM1 POLR2B 25348397 N/A physical interaction ComPPI
INO80B POLR2B 25348397 N/A physical interaction ComPPI
SRC POLR2B 25348397 N/A physical interaction ComPPI
GTF2F2 POLR2B 25348397 N/A physical interaction ComPPI
CPNE2 POLR2B 25348397 N/A physical interaction ComPPI
GSK3B POLR2B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CUL3 POLR2B 25348397 N/A physical interaction ComPPI
NTRK1 POLR2B 25348397 N/A physical interaction ComPPI
RUVBL1 POLR2B 25348397 N/A physical interaction ComPPI
ILK POLR2B 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SUB1 POLR2B 25348397 N/A physical interaction ComPPI
XRN2 POLR2B 25348397 N/A physical interaction ComPPI
PSMB9 POLR2B 25348397 N/A physical interaction ComPPI
MYC POLR2B 17314511 17353931 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
EEF1A1 POLR2B 25348397 N/A physical interaction ComPPI
TUBA4A POLR2B 25348397 N/A physical interaction ComPPI
DCTN1 POLR2B 25348397 N/A physical interaction ComPPI
MAPK6 POLR2B 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
CTR9 POLR2B 25348397 N/A physical interaction ComPPI
XPO1 POLR2B 25348397 N/A physical interaction ComPPI
DNAJC7 POLR2B 25348397 N/A physical interaction ComPPI
LMO2 POLR2B 25348397 N/A physical interaction ComPPI
CTDP1 POLR2B 14525934 15670829 24234451 25348397 physical association affinity chromatography technology,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
MED9 POLR2B 15175163 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RNF2 POLR2B 25348397 N/A physical interaction ComPPI
TCEA1 POLR2B 25348397 N/A physical interaction ComPPI
GTF2F1 POLR2B 25348397 N/A physical interaction ComPPI
URI1 POLR2B 25348397 N/A physical interaction ComPPI
POLR2E POLR2B 24234451 25348397 27193682 physical association physical interaction,electron tomography ComPPI,IntAct
BRD2 POLR2B 25348397 N/A physical interaction ComPPI
CDK7 POLR2B 25348397 N/A physical interaction ComPPI
POLR2A POLR2B 25348397 N/A physical interaction ComPPI
ITCH POLR2B 25348397 N/A physical interaction ComPPI
TUBB4B POLR2B 25348397 N/A physical interaction ComPPI
WWOX POLR2B 16055720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
MDC1 POLR2B 25348397 N/A physical interaction ComPPI
MED28 POLR2B 25348397 N/A physical interaction ComPPI
HIF1AN POLR2B 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
GPN1 POLR2B 25348397 N/A physical interaction ComPPI
MED26 POLR2B 15175163 21729782 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HDAC11 POLR2B 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAND1 POLR2B 25348397 N/A physical interaction ComPPI
SUPT5H POLR2B 25348397 N/A physical interaction ComPPI
NEDD4 POLR2B 25348397 N/A physical interaction ComPPI
BARD1 POLR2B 25348397 N/A physical interaction ComPPI
AIRE POLR2B 25348397 N/A physical interaction ComPPI
SEM1 POLR2B 25348397 N/A physical interaction ComPPI
MAGI2 POLR2B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRIM25 POLR2B 25348397 N/A physical interaction ComPPI
NKX3-1 POLR2B 25348397 N/A physical interaction,tandem affinity purification ComPPI
ELOA POLR2B 25348397 N/A physical interaction ComPPI
ESR1 POLR2B 25348397 N/A physical interaction ComPPI
KDM1A POLR2B 25348397 N/A physical interaction ComPPI
RECQL5 POLR2B 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
POLR2K POLR2B 25348397 N/A physical interaction ComPPI
HECW2 POLR2B 25348397 N/A physical interaction ComPPI
POLR2J POLR2B 25348397 N/A physical interaction ComPPI
TADA2A POLR2B 25348397 N/A physical interaction ComPPI
POLR1A POLR2B 25348397 N/A physical interaction ComPPI
POLR3A POLR2B 25348397 N/A physical interaction ComPPI
RNGTT POLR2B 25348397 N/A physical interaction ComPPI
POLR2F POLR2B 25348397 N/A physical interaction ComPPI
POLR2C POLR2B 14525934 18562274 24234451 25348397 9201987 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
POLR2G POLR2B 25348397 N/A physical interaction ComPPI
POLR3F POLR2B 25348397 N/A physical interaction ComPPI
IFI16 POLR2B 25348397 N/A physical interaction ComPPI
POLR1B POLR2B 25348397 N/A physical interaction ComPPI
SUZ12 POLR2B 25348397 N/A physical interaction ComPPI
MED19 POLR2B 15175163 21729782 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RUVBL2 POLR2B 25348397 N/A physical interaction ComPPI
POLR2D POLR2B 10567706 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NELFA POLR2B 25348397 N/A physical interaction ComPPI
MED4 POLR2B 25348397 N/A physical interaction ComPPI
ERCC2 POLR2B 24234451 25348397 27193682 physical association electron tomography ComPPI,IntAct
POLR2H POLR2B 14525934 25348397 9201987 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
POLR2B MEN1 14525934 14992727 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
POLR2B MED10 15175163 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2B MED29 15175163 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2B RPAP2 25348397 N/A physical interaction ComPPI
POLR2B RPAP3 25348397 N/A physical interaction ComPPI
POLR2B RPAP1 25348397 N/A physical interaction ComPPI
POLR2B IKBKG 25348397 N/A physical interaction ComPPI
POLR2B ZSCAN1 25348397 N/A physical interaction ComPPI
POLR2B INTS3 25348397 N/A physical interaction ComPPI
POLR2B INTS5 25348397 N/A physical interaction ComPPI
POLR2B INTS6 25348397 N/A physical interaction ComPPI
POLR2B INTS1 25348397 N/A physical interaction ComPPI
POLR2B ZC3H13 25348397 N/A physical interaction ComPPI
POLR2B WDR82 25348397 N/A physical interaction ComPPI
POLR2B SEM1 25348397 N/A physical interaction ComPPI
POLR2B INTS10 25348397 N/A physical interaction ComPPI
POLR2B PIDD1 25348397 N/A physical interaction ComPPI
POLR2B POLR2I 25348397 N/A physical interaction ComPPI
POLR2B CDK20 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
POLR2B FBXO6 25348397 N/A physical interaction ComPPI
POLR2B RABEP2 25348397 N/A physical interaction ComPPI
POLR2B OBSL1 25348397 N/A physical interaction ComPPI
POLR2B RPRD1B 25348397 N/A physical interaction ComPPI
POLR2B GPN2 25348397 N/A physical interaction ComPPI
POLR2B MYZAP 25348397 N/A physical interaction ComPPI
POLR2B POLR2M 25348397 N/A physical interaction ComPPI
POLR2B EEF1A1P5 25348397 N/A physical interaction ComPPI
POLR2B EEFSEC 25348397 N/A physical interaction ComPPI
POLR2B RPS5 25348397 N/A physical interaction ComPPI
POLR2B GPN3 25348397 N/A physical interaction ComPPI
POLR2B PIH1D1 25348397 N/A physical interaction ComPPI
POLR2B ASB6 25348397 N/A physical interaction ComPPI
POLR2B NCL 25348397 N/A physical interaction ComPPI
POLR2B AAR2 25348397 N/A physical interaction ComPPI
POLR2B DNAAF10 25348397 N/A physical interaction ComPPI
POLR2B ZNHIT2 25348397 N/A physical interaction ComPPI
POLR2B G3BP1 25348397 N/A physical interaction ComPPI
POLR2B TET3 23353889 24234451 25348397 association pull down ComPPI,IntAct
POLR2B RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
POLR2B NBEAL2 24234451 25348397 29187380 association tandem affinity purification ComPPI,IntAct
LZTR1 POLR2B 25348397 N/A physical interaction ComPPI
ATP6V1B2 POLR2B 25348397 N/A physical interaction ComPPI
ABL2 POLR2B 27898060 7504297 N/A N/A OmniPath
ABL1 POLR2B 27898060 7504297 N/A N/A OmniPath

Visualization










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