Gene Information gene info

GENE:PPA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPA2
FullNmae inorganic pyrophosphatase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:28883
EnsembleID ENSG00000138777
Uniprot Q9H2U2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPA2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PPA2 GO:0000287,GO:0004427,GO:0004427,GO:0004722,GO:0005739,GO:0005739,GO:0005759,GO:0006796,GO:0045202,GO:0051881,GO:0071344

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPA2 hsa:27068 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PPA2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 PPA2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 PPA2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PPA2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PPA2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 PPA2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PPA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 PPA2 21512034 25416803 mrna cleavage,inhibition experimental interaction detection TarBase

Source Target Pmid Interactiontype Methods Database
CHCHD2 PPA2 25348397 N/A physical interaction ComPPI
BAG3 PPA2 25348397 N/A physical interaction ComPPI
CD2AP PPA2 25348397 N/A physical interaction ComPPI
DUT PPA2 25348397 N/A physical interaction ComPPI
AIP PPA2 25348397 N/A physical interaction ComPPI
MYC PPA2 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
NEDD8 PPA2 25348397 N/A physical interaction ComPPI
HTT PPA2 17500595 24234451 25348397 physical association two hybrid ComPPI,IntAct
PLIN3 PPA2 25348397 N/A physical interaction ComPPI
PDK1 PPA2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPP PPA2 25348397 N/A physical interaction ComPPI
SYNC PPA2 25348397 N/A physical interaction ComPPI
METTL1 PPA2 25348397 N/A physical interaction ComPPI
ZWINT PPA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAT PPA2 25348397 N/A physical interaction ComPPI
COMT PPA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EZR PPA2 25348397 N/A physical interaction ComPPI
HSPD1 PPA2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NIPSNAP3A PPA2 25348397 N/A physical interaction ComPPI
GLS PPA2 25348397 N/A physical interaction ComPPI
UFM1 PPA2 25348397 N/A physical interaction ComPPI
TRMT61B PPA2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FKBP14 PPA2 25348397 N/A physical interaction ComPPI
H1-3 PPA2 25348397 N/A physical interaction ComPPI
SIRT4 PPA2 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
PNPT1 PPA2 25348397 N/A physical interaction ComPPI
PDPR PPA2 25348397 N/A physical interaction ComPPI
LYRM7 PPA2 25348397 N/A physical interaction ComPPI

Visualization