GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
PPA2
FullNmae
inorganic pyrophosphatase 2
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:28883
EnsembleID
ENSG00000138777
Uniprot
Q9H2U2
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
PPA2
cuproptosis
36010978
Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1.
Cuproptosis-related genes
Go Annotation:
GeneSymbol
Go id
PPA2
GO:0000287,GO:0004427,GO:0004427,GO:0004722,GO:0005739,GO:0005739,GO:0005759,GO:0006796,GO:0045202,GO:0051881,GO:0071344
KEGG Annotation:
GeneSymbol
GeneID
Pathway
Pathway Name
PPA2
hsa:27068
path:hsa00190
Oxidative phosphorylation - Homo sapiens (human)
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
AR
PPA2
20610535
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
E2F4
PPA2
17531812
18971253
trascriptional regulation,stimulation
chromatin immunoprecipitation array,inferred by curator
TFlink
ETS1
PPA2
18971253
20019798
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
GATA1
PPA2
19941826
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
GATA2
PPA2
18971253
19941826
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
PRDM14
PPA2
18971253
20953172
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
SMARCA4
PPA2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CTCF
PPA2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
E2F1
PPA2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
EGR1
PPA2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOXP1
PPA2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOS
PPA2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOXA1
PPA2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
HNF4A
PPA2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
URS00000AA464
PPA2
21512034
25416803
mrna cleavage,inhibition
experimental interaction detection
TarBase
Source
Target
Pmid
Interactiontype
Methods
Database
CHCHD2
PPA2
25348397
N/A
physical interaction
ComPPI
BAG3
PPA2
25348397
N/A
physical interaction
ComPPI
CD2AP
PPA2
25348397
N/A
physical interaction
ComPPI
DUT
PPA2
25348397
N/A
physical interaction
ComPPI
AIP
PPA2
25348397
N/A
physical interaction
ComPPI
MYC
PPA2
21150319
24234451
25348397
association
tandem affinity purification
ComPPI,IntAct
NEDD8
PPA2
25348397
N/A
physical interaction
ComPPI
HTT
PPA2
17500595
24234451
25348397
physical association
two hybrid
ComPPI,IntAct
PLIN3
PPA2
25348397
N/A
physical interaction
ComPPI
PDK1
PPA2
24234451
25348397
29568061
association
proximity-dependent biotin identification
ComPPI,IntAct
CLPP
PPA2
25348397
N/A
physical interaction
ComPPI
SYNC
PPA2
25348397
N/A
physical interaction
ComPPI
METTL1
PPA2
25348397
N/A
physical interaction
ComPPI
ZWINT
PPA2
24234451
25348397
26496610
association
anti tag coimmunoprecipitation,physical interaction
ComPPI,IntAct
CAT
PPA2
25348397
N/A
physical interaction
ComPPI
COMT
PPA2
24234451
25348397
26496610
association
anti tag coimmunoprecipitation,physical interaction
ComPPI,IntAct
EZR
PPA2
25348397
N/A
physical interaction
ComPPI
HSPD1
PPA2
24234451
25348397
29568061
association
proximity-dependent biotin identification
ComPPI,IntAct
NIPSNAP3A
PPA2
25348397
N/A
physical interaction
ComPPI
GLS
PPA2
25348397
N/A
physical interaction
ComPPI
UFM1
PPA2
25348397
N/A
physical interaction
ComPPI
TRMT61B
PPA2
24234451
25348397
29568061
association
proximity-dependent biotin identification
ComPPI,IntAct
FKBP14
PPA2
25348397
N/A
physical interaction
ComPPI
H1-3
PPA2
25348397
N/A
physical interaction
ComPPI
SIRT4
PPA2
24234451
25348397
25525879
association
anti tag coimmunoprecipitation
ComPPI,IntAct
PNPT1
PPA2
25348397
N/A
physical interaction
ComPPI
PDPR
PPA2
25348397
N/A
physical interaction
ComPPI
LYRM7
PPA2
25348397
N/A
physical interaction
ComPPI
Visualization