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GENE：PPP1R15A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPP1R15A
FullNmae protein phosphatase 1 regulatory subunit 15A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14375
EnsembleID ENSG00000087074
Uniprot O75807

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPP1R15A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP1R15A apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP1R15A apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PPP1R15A cuproptosis 38365764 In our study, we demonstrated that elesclomol, as a carrier of copper ions, caused an upregulation of protein phosphatase 1 regulatory subunit 15 A (PPP1R15A), which plays a role in regulating substrate selectivity of protein phosphatase 1 during cuproptosis. regulator

Go Annotation:

GeneSymbol Go id
PPP1R15A GO:0000164,GO:0000164,GO:0005515,GO:0005737,GO:0005739,GO:0005741,GO:0005783,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006915,GO:0006974,GO:0008157,GO:0008157,GO:0016020,GO:0019888,GO:0019888,GO:0019901,GO:0032058,GO:0032515,GO:0032516,GO:0032516,GO:0034976,GO:0034976,GO:0035308,GO:0036496,GO:0051726,GO:0070059,GO:0070972,GO:0072542,GO:1902310,GO:1903898,GO:1903917,GO:1903917

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPP1R15A hsa:23645 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PPP1R15A TSC1 17273797 23180781 physical association anti tag coimmunoprecipitation InnateDB
PPP1R15A CUEDC2 18362886 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
CUEDC2 PPP1R15A 18362886 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKB PPP1R15A 18362886 23180781 physical association anti tag coimmunoprecipitation InnateDB
DDIT3 PPP1R15A 20038797 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAD21 PPP1R15A 22145905 23180781 physical association two hybrid InnateDB
PPP1R15A POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB
CTBP2 PPP1R15A 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
JUN PPP1R15A 23180781 25204313 physical association anti tag coimmunoprecipitation InnateDB
SMAD7 PPP1R15A 14718519 23331499 stimulation N/A SignaLink
PPP1R15A PPP1CC 11564868 14670976 14718519 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PPP1R15A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PPP1R15A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PPP1R15A 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 PPP1R15A 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 PPP1R15A 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PPP1R15A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PPP1R15A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPP1R15A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PPP1R15A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 PPP1R15A N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002075FA PPP1R15A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001DABC0 PPP1R15A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F PPP1R15A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D PPP1R15A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000204177 PPP1R15A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000521626 PPP1R15A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 PPP1R15A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 PPP1R15A 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 PPP1R15A 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AB32B PPP1R15A 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000027352D PPP1R15A 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003D4175 PPP1R15A 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003FBC84 PPP1R15A 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000006372A PPP1R15A 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001496AE PPP1R15A 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PPP1R15A BAG1 25361965 interaction type N/A PTMCode2
BAG1 PPP1R15A 25361965 interaction type N/A PTMCode2
PPP1R15A EIF2S1 25361965 interaction type N/A PTMCode2
EIF2S1 PPP1R15A 25361965 interaction type N/A PTMCode2
PPP1R15A PPP1R1A 25361965 interaction type N/A PTMCode2
PPP1R1A PPP1R15A 25361965 interaction type N/A PTMCode2
PPP1R15A SMARCB1 25361965 interaction type N/A PTMCode2
SMARCB1 PPP1R15A 25361965 interaction type N/A PTMCode2
PPP1R15A PPP1CA 25361965 interaction type N/A PTMCode2
PPP1CA PPP1R15A 25361965 interaction type N/A PTMCode2
PPP1R15A KIF3A 25361965 interaction type N/A PTMCode2
KIF3A PPP1R15A 25361965 interaction type N/A PTMCode2
PPP1R15A TSN 25361965 interaction type N/A PTMCode2
TSN PPP1R15A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSPA8 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA2 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
KRT2 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1CC PPP1R15A 25348397 N/A physical interaction ComPPI
PSMC6 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
CLNS1A PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1CB PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD21 PPP1R15A 25348397 N/A physical interaction ComPPI
ZNF512B PPP1R15A 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KEAP1 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
SMN1 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
H2AC11 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
SMAD7 PPP1R15A 25348397 N/A physical interaction ComPPI
LYN PPP1R15A 11517336 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PPP1R15A BAG1 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
PPP1R15A SMARCB1 10490642 12016208 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PPP1R15A EIF2S1 12556489 14525934 24234451 25348397 27898060 29109149 association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
PPP1R15A TSN 10434033 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PPP1R15A HABP4 14525934 16455055 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PPP1R15A PPP1R1A 11564868 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PPP1R15A POU3F3 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PPP1R15A HSPA1A 12724406 14525934 24234451 25348397 29109149 association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
PPP1R15A HSPA1B 25348397 N/A anti tag coimmunoprecipitation,in vivo ComPPI
PPP1R15A PPP1CA 14525934 15231748 24234451 25348397 29109149 association,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
PPP1R15A KMT2A 10490642 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PPP1R15A BCAR1 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PPP1R15A CUEDC2 25348397 N/A physical interaction ComPPI
PPP1R15A IKBKB 25348397 N/A physical interaction ComPPI
PPP1R15A CUL3 25348397 N/A physical interaction ComPPI
PPP1R15A COPS5 25348397 N/A physical interaction ComPPI
PPP1R15A CAND1 25348397 N/A physical interaction ComPPI
PPP1R15A CTBP2 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
PPP1R15A PLEKHA1 25348397 N/A physical interaction ComPPI
PPP1R15A MINK1 25348397 N/A physical interaction ComPPI
PPP1R15A ZNF92 25348397 N/A physical interaction ComPPI
PPP1R15A POP4 25348397 N/A physical interaction ComPPI
PPP1R15A PWWP3A 25348397 N/A physical interaction ComPPI
PPP1R15A BBX 25348397 N/A physical interaction ComPPI
PPP1R15A MYC 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PPP1R15A CEP290 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A TRAFD1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A GTSE1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A HADHA 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A TRIM28 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A EEF2 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A TUBB8 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A ACTBL2 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A COPB1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A HSPA5 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A KRT9 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A GTPBP1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A KRT10 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A KIF11 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A AIFM1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A TRAP1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A AKAP8L 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A DAP3 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A CCT8 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A PPP2R2A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A STOML2 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A DDX3X 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A CHEK1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A YME1L1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A SNX18 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A IGKV2-29 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A HSPH1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A MAGED4 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A NUFIP1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A DDX52 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A ZNF629 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A LAS1L 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A GTF3C3 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A TUBB2B 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A ESYT2 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A MAGED2 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A TARS2 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A GTF3C4 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A SLC25A13 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A SLFN11 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A THAP4 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A TMEM183A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A NACA 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A PSMC5 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A TARDBP 24234451 25348397 29109149 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct
PPP1R15A NOM1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A SSRP1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A KRT1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A IRS4 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A TOMM70 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A ABCF1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A NCAPH2 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A CBX4 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A KNOP1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A PARP1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A HNRNPA2B1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A ERAL1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A NOP56 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A TIMM50 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A DNAJA2 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A HNRNPM 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A IPO5 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A CNP 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A RNF138 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A PRPSAP2 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A TRIP13 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A EIF2S3 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A MYO1C 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A PRC1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A NR2F1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A ABCE1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A ALDOA 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A PRPSAP1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A CKAP4 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A PSMD11 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A HNRNPH1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A ATAD3A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A SPTLC1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A DUSP11 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A HADHB 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A SGPL1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A PDCD2 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A ZNF281 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A LIMA1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A MICU1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A PRKCE 24234451 25348397 29109149 physical association anti tag coimmunoprecipitation ComPPI,IntAct
CSNK2A2 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
TCP1 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
HNRNPF PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
WDR5 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
OBI1 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
ALDH18A1 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1R15A KIF3A 10631107 14525934 27898060 N/A experimental interaction detection,two hybrid HPRD,OmniPath
PLEC PPP1R15A 24234451 30021884 physical association cross-linking study IntAct
LYN PPP1R15A 11517336 27898060 stimulant N/A OmniPath
BAG1 PPP1R15A 12724406 27898060 inhibition N/A OmniPath
MAPK14 PPP1R15A 11163539 27898060 stimulant N/A OmniPath
PPP1R15A TSC1 17273797 27898060 N/A N/A OmniPath
IKBKB PPP1R15A 18362886 27898060 N/A N/A OmniPath
SMAD7 PPP1R15A 14718519 27898060 stimulant N/A OmniPath
PPP1R15A PPP1CC 11564868 12016208 14670976 14718519 27898060 stimulant N/A OmniPath

Visualization










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