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GENE：PRC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRC1
FullNmae protein regulator of cytokinesis 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9341
EnsembleID ENSG00000198901
Uniprot O43663

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRC1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRC1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PRC1 GO:0000022,GO:0000226,GO:0000922,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005819,GO:0005819,GO:0005829,GO:0005876,GO:0005886,GO:0008017,GO:0008284,GO:0015630,GO:0019894,GO:0019901,GO:0030496,GO:0032465,GO:0045171,GO:0051256,GO:0051301,GO:0070938,GO:1990023

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PRC1 TRIM37 16189514 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 PRC1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 PRC1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PRC1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PRC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PRC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PRC1 12889596 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000508C13 PRC1 N/A 15685193 rna interference,inhibition array technology miRSponge
URS0000508C13 PRC1 15685193 25416803 mrna cleavage,inhibition array technology,array technology,experimental interaction detection TarBase
URS000039A25B PRC1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000017EA6A PRC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001F0C23 PRC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000239117 PRC1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000D6C3F PRC1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C PRC1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 PRC1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C PRC1 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 PRC1 22135298 phosphorylation N/A PhosphoSite
PLK1 PRC1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SH3KBP1 PRC1 25348397 N/A physical interaction ComPPI
KRT20 PRC1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
H2BC4 PRC1 25348397 N/A physical interaction ComPPI
CCDC85B PRC1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
IFI30 PRC1 25348397 N/A physical interaction ComPPI
RACGAP1 PRC1 14525934 14744859 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
PPP1R15A PRC1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PLK1 PRC1 14525934 17351640 19468300 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PKIA PRC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DCTN1 PRC1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
GTPBP1 PRC1 25348397 N/A physical interaction ComPPI
CDK2 PRC1 14525934 25348397 9885575 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CCNB1 PRC1 25348397 N/A physical interaction ComPPI
H3C1 PRC1 25348397 N/A physical interaction ComPPI
KAT6B PRC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM25 PRC1 25348397 N/A physical interaction ComPPI
LTBR PRC1 25348397 N/A physical interaction ComPPI
BRCA1 PRC1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
CCNA2 PRC1 25348397 N/A physical interaction ComPPI
MAT2A PRC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM37 PRC1 14525934 16189514 19447967 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid pooling approach,two hybrid ComPPI,HPRD,IntAct
KIF23 PRC1 25348397 N/A physical interaction ComPPI
TACC2 PRC1 25348397 N/A physical interaction ComPPI
EXOSC2 PRC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KIF4A PRC1 25348397 N/A physical interaction,fluorescence microscopy ComPPI
USHBP1 PRC1 14525934 16189514 19447967 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CCNE1 PRC1 25348397 N/A physical interaction ComPPI
WDR5 PRC1 25348397 N/A physical interaction ComPPI
PRC1 CENPE 25348397 N/A physical interaction ComPPI
PRC1 CDK1 25348397 N/A physical interaction ComPPI
PRC1 H2BC11 25348397 N/A physical interaction ComPPI
PRC1 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
PRC1 NANOGP8 25348397 N/A physical interaction ComPPI
PRC1 NANOG 25348397 N/A physical interaction ComPPI
PRC1 ACSM1 25348397 N/A physical interaction ComPPI
PRC1 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PRC1 CINP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CHCHD3 PRC1 24234451 30021884 physical association cross-linking study IntAct
SHANK3 PRC1 24234451 30021884 physical association cross-linking study IntAct
EPB41L2 PRC1 24234451 30021884 physical association cross-linking study IntAct
PRC1 ERN1 21775630 21852455 27898060 N/A N/A OmniPath
PRC1 SYVN1 16619026 22298424 24292014 27898060 N/A N/A OmniPath
PRC1 DERL1 16619026 21486563 24292014 27898060 N/A N/A OmniPath
PLK1 PRC1 17351640 22621898 23940115 25512391 27898060 N/A N/A OmniPath
TTK PRC1 12686615 14657364 27898060 inhibition N/A OmniPath
CDK2 PRC1 18212344 18691976 20068230 27898060 9885575 N/A N/A OmniPath
KIF4A PRC1 15297875 15625105 27898060 stimulant N/A OmniPath
TP53 PRC1 15531928 27898060 inhibition N/A OmniPath
CDK1 PRC1 16603632 16964243 17351640 17438553 17512944 18691976 27898060 9885575 stimulant N/A OmniPath

Visualization










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