Gene Information gene info

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GENE：PRDX1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRDX1
FullNmae peroxiredoxin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9352
EnsembleID ENSG00000117450
Uniprot Q06830

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRDX1 cuproptosis 36550822 Next, 11 hub CAGs(cuproptosis-associated genes), including COPB2, MRPL39, PGK1, PRDX1, PCMT1, MPZL3, LACTB2, HSPH1, DIP2B, DLG3, and NFKBIA, were applied to construct a novel prognostic risk signature for BR. cuproptosis-associated gene

Go Annotation:

GeneSymbol Go id
PRDX1 GO:0001501,GO:0001895,GO:0003723,GO:0004601,GO:0004601,GO:0005515,GO:0005615,GO:0005634,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0006979,GO:0008283,GO:0008379,GO:0008379,GO:0019430,GO:0030101,GO:0032872,GO:0033554,GO:0034101,GO:0042267,GO:0042470,GO:0042744,GO:0042744,GO:0042802,GO:0045296,GO:0045321,GO:0045454,GO:0048144,GO:0070062,GO:1901222

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRDX1 hsa:5052 path:hsa04146 Peroxisome - Homo sapiens (human)
PRDX1 hsa:5052 path:hsa05146 Amoebiasis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NFE2L2 PRDX1 10441483 10821856 10874044 11279008 11909699 12356737 12511571 15521073 16219762 17512463 18761713 19027064 19747488 23850759 26192618 interaction type N/A ACSN
ELP1 PRDX1 18303054 23180781 physical association anti tag coimmunoprecipitation InnateDB
ISG15 PRDX1 16009940 23180781 physical association unspecified method InnateDB
SUZ12 PRDX1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
PRDX1 DUSP1 23334324 interaction type,stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PRDX1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PRDX1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PRDX1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PRDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PRDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PRDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PRDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PRDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PRDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PRDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PRDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PRDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 PRDX1 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS000035CC3E PRDX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE PRDX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000183BED PRDX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B PRDX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC4BD PRDX1 23971998 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 PRDX1 22135298 phosphorylation N/A PhosphoSite
LCK PRDX1 22135298 phosphorylation N/A PhosphoSite
STK4 PRDX1 22135298 phosphorylation N/A PhosphoSite
PBK PRDX1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CDC73 PRDX1 25348397 N/A physical interaction ComPPI
CUL5 PRDX1 25348397 N/A physical interaction ComPPI
TSNAX PRDX1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC42 PRDX1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ISG15 PRDX1 25348397 N/A physical interaction ComPPI
CFL1 PRDX1 25348397 N/A physical interaction ComPPI
PPP2R1A PRDX1 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
UBL4A PRDX1 25348397 N/A physical interaction ComPPI
MCM5 PRDX1 25348397 N/A physical interaction ComPPI
GABARAPL2 PRDX1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CALM1 PRDX1 25348397 N/A physical interaction ComPPI
DCUN1D1 PRDX1 25348397 N/A physical interaction ComPPI
KEAP1 PRDX1 25348397 N/A physical interaction ComPPI
MCM2 PRDX1 25348397 N/A physical interaction ComPPI
MAP1LC3B PRDX1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NF2 PRDX1 25348397 N/A physical interaction ComPPI
DAB2 PRDX1 25348397 N/A physical interaction ComPPI
SHC1 PRDX1 25348397 N/A physical interaction ComPPI
PRKDC PRDX1 25348397 N/A physical interaction ComPPI
GRB2 PRDX1 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN PRDX1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
AR PRDX1 17909037 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
SMARCD1 PRDX1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
COPS5 PRDX1 25348397 N/A physical interaction ComPPI
ARHGEF2 PRDX1 25348397 N/A physical interaction ComPPI
U2AF2 PRDX1 25348397 N/A physical interaction ComPPI
CUL3 PRDX1 25348397 N/A physical interaction ComPPI
GAPDH PRDX1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
YWHAZ PRDX1 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
NTRK1 PRDX1 25348397 N/A physical interaction ComPPI
RNH1 PRDX1 25348397 N/A physical interaction ComPPI
CDH1 PRDX1 25348397 N/A physical interaction ComPPI
BTRC PRDX1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRF3 PRDX1 14525934 16189514 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
AXIN2 PRDX1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RPA1 PRDX1 25348397 N/A physical interaction ComPPI
MSH6 PRDX1 25348397 N/A physical interaction ComPPI
PRDX4 PRDX1 14525934 21988832 24234451 25348397 27898060 9388242 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
PRDX1 MT-RNR2 25348397 N/A two hybrid ComPPI
PRDX1 SESN2 14525934 15105503 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRDX1 SESN1 14525934 15105503 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRDX1 MYC 12196529 14525934 21988832 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
PRDX1 PPP2R1B 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PRDX1 EGFR 20029029 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
PRDX1 UCHL5 25348397 N/A physical interaction ComPPI
PRDX1 AGO4 19167051 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRDX1 UBE3A 25348397 N/A physical interaction ComPPI
PRDX1 CLEC4G 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRDX1 PIDD1 25348397 N/A physical interaction ComPPI
PRDX1 TERF1 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PRDX1 CUL4A 25348397 N/A physical interaction ComPPI
PRDX1 CUL4B 25348397 N/A physical interaction ComPPI
PRDX1 CUL2 25348397 N/A physical interaction ComPPI
PRDX1 CDK2 25348397 N/A physical interaction ComPPI
PRDX1 CUL1 25348397 N/A physical interaction ComPPI
PRDX1 COPS6 25348397 N/A physical interaction ComPPI
PRDX1 CAND1 25348397 N/A physical interaction ComPPI
PRDX1 NEDD8 25348397 N/A physical interaction ComPPI
PRDX1 EPS15 25348397 N/A physical interaction ComPPI
PRDX1 MTRNR2L1 25348397 N/A physical interaction ComPPI
PRDX1 SNCA 25348397 N/A physical interaction ComPPI
PRDX1 PRDX2 25348397 N/A physical interaction ComPPI
PRDX1 ACAA2 25348397 N/A physical interaction ComPPI
PRDX1 PRDX5 25348397 N/A physical interaction ComPPI
PRDX1 PEBP1 25348397 N/A physical interaction ComPPI
PRDX1 SOD1 25348397 N/A physical interaction ComPPI
PRDX1 URM1 25348397 N/A physical interaction ComPPI
PRDX1 YAP1 25348397 N/A physical interaction ComPPI
PRDX1 TPM3 25348397 N/A physical interaction ComPPI
PRDX1 USP5 25348397 N/A physical interaction ComPPI
PRDX1 TIPRL 25348397 N/A physical interaction ComPPI
PRDX1 DNPH1 25348397 N/A physical interaction ComPPI
PRDX1 ZFR 25348397 N/A physical interaction ComPPI
PRDX1 PRDX6 25348397 N/A physical interaction ComPPI
PRDX1 RAD23A 25348397 N/A physical interaction ComPPI
PRDX1 UBE2H 25348397 N/A physical interaction ComPPI
PRDX1 TKT 25348397 N/A physical interaction ComPPI
PRDX1 SH3BGRL2 25348397 N/A physical interaction ComPPI
PRDX1 MAGOH 25348397 N/A physical interaction ComPPI
PRDX1 ELP1 25348397 N/A physical interaction ComPPI
PRDX1 TXN 17557078 24234451 25348397 physical association cross-linking study,physical interaction ComPPI,IntAct
PRDX1 FN1 25348397 N/A physical interaction ComPPI
PRDX1 VCAM1 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PRDX1 ABL1 17352427 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PRDX1 IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRDX1 ITGA4 25348397 N/A physical interaction ComPPI
PRDX1 MPG 25348397 N/A physical interaction ComPPI
PRDX1 RAD52 19338310 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRDX1 LUC7L 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRDX1 ADH5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRDX1 MYD88 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRDX1 SH2D1B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRDX1 VHL 25348397 N/A physical interaction ComPPI
PRDX1 PRKN 25348397 N/A physical interaction ComPPI
PRDX1 CACYBP 25348397 N/A physical interaction ComPPI
PRDX1 HECTD1 25348397 N/A physical interaction ComPPI
PRDX1 METTL1 25348397 N/A physical interaction ComPPI
PRDX1 RPA3 25348397 N/A physical interaction ComPPI
PRDX1 RPA2 25348397 N/A physical interaction ComPPI
PRDX1 FUS 25348397 N/A physical interaction ComPPI
PRDX1 CUL7 25348397 N/A physical interaction ComPPI
PRDX1 OBSL1 25348397 N/A physical interaction ComPPI
PRDX1 SUZ12 25348397 N/A physical interaction ComPPI
PRDX1 PPT1 25348397 N/A physical interaction ComPPI
PRDX1 RPS6KB2 25348397 N/A physical interaction ComPPI
PRDX1 HNRNPA1 25348397 N/A physical interaction ComPPI
PRDX1 BAX 25348397 N/A physical interaction ComPPI
PRDX1 CAT 25348397 N/A physical interaction ComPPI
PRDX1 DAZAP1 25348397 N/A physical interaction ComPPI
PRDX1 FSCN1 25348397 N/A physical interaction ComPPI
PRDX1 LAP3 25348397 N/A physical interaction ComPPI
PRDX1 NANS 25348397 N/A physical interaction ComPPI
PRDX1 SPR 25348397 N/A physical interaction ComPPI
PRDX1 TANGO2 25348397 N/A physical interaction ComPPI
PRDX1 PRDX3 25348397 N/A physical interaction ComPPI
PRDX1 UBE2M 25348397 N/A physical interaction ComPPI
PRDX1 PTEN 19369943 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
PRDX1 CCNB1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRDX1 MPP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRDX1 ANAPC15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRDX1 RAB4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRDX1 MIA 25348397 N/A physical interaction ComPPI
PRDX1 FERMT3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRDX1 GAN 25348397 N/A physical interaction ComPPI
PRDX1 SKI 25348397 N/A physical interaction ComPPI
PRDX1 CRY1 25348397 N/A physical interaction ComPPI
PRDX1 TRIM4 25348397 N/A physical interaction ComPPI
PRDX1 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRDX1 CYLD 25348397 N/A physical interaction ComPPI
PRDX1 TRIM25 25348397 N/A physical interaction ComPPI
PRDX1 G3BP1 25348397 N/A physical interaction ComPPI
PRDX1 BRCA1 25348397 N/A physical interaction ComPPI
PRDX1 DCAF4L2 25348397 N/A physical interaction ComPPI
PRDX1 CFTR 25348397 N/A physical interaction ComPPI
PRDX1 SRXN1 18172504 24234451 25348397 N/A classical fluorescence spectroscopy,x-ray crystallography,physical interaction,enzymatic study ComPPI,IntAct
PRDX1 KDM1A 25348397 N/A pull down,physical interaction ComPPI
PRDX1 RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PRDX1 PPP2R2B 19156129 24234451 25348397 association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
PRDX1 MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRDX1 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRDX1 GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRDX1 STK4 23386615 24234451 25348397 phosphorylation reaction,association,physical association anti tag coimmunoprecipitation,two hybrid,pull down,protein kinase assay,tandem affinity purification ComPPI,IntAct
PRDX1 STK3 23386615 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PRDX1 NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
PRDX1 TUBB3 24234451 25348397 27291054 association pull down ComPPI,IntAct
PRDX1 TUBA1A 24234451 25348397 27291054 association pull down ComPPI,IntAct
PRDX1 NABP2 19683501 24234451 25348397 association pull down ComPPI,IntAct
PRDX1 PPP1CA 24234451 25348397 25593058 association anti bait coimmunoprecipitation ComPPI,IntAct
YWHAQ PRDX1 25348397 N/A physical interaction ComPPI
ASS1 PRDX1 25348397 N/A physical interaction ComPPI
PPP2R5D PRDX1 25348397 N/A physical interaction ComPPI
TIPIN PRDX1 25348397 N/A physical interaction ComPPI
EIF4A3 PRDX1 25348397 N/A physical interaction ComPPI
ADRM1 PRDX1 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PRDX1 PRDX1 14525934 16376335 18172504 24234451 N/A experimental interaction detection,molecular sieving HPRD,IntAct
WTAP PRDX1 24234451 29507755 association anti tag coimmunoprecipitation IntAct
METTL14 PRDX1 24234451 29507755 association anti tag coimmunoprecipitation IntAct
ADRB2 PRDX1 24234451 28298427 physical association ubiquitin reconstruction IntAct
CCR4 PRDX1 24234451 28298427 physical association ubiquitin reconstruction IntAct
PTGER4 PRDX1 24234451 28298427 physical association ubiquitin reconstruction IntAct
TPT1 PRDX1 24234451 27607350 association,physical association anti bait coimmunoprecipitation,bimolecular fluorescence complementation IntAct
LCK PRDX1 20178744 27898060 N/A N/A OmniPath
CDK6 PRDX1 11986303 27898060 inhibition N/A OmniPath
CDK2 PRDX1 11986303 27898060 inhibition N/A OmniPath
CDK1 PRDX1 11986303 16376335 23386615 26150388 27898060 inhibition N/A OmniPath
NFE2L2 PRDX1 15289456 27898060 stimulant N/A OmniPath
CDK4 PRDX1 11986303 27898060 inhibition,stimulant N/A OmniPath
ISG15 PRDX1 16009940 16815975 27898060 N/A N/A OmniPath
PBK PRDX1 20647304 27898060 stimulant N/A OmniPath

Visualization










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