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GENE：RAD9A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RAD9A
FullNmae RAD9 checkpoint clamp component A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9827
EnsembleID ENSG00000172613
Uniprot Q99638

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RAD9A parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RAD9A mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RAD9A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RAD9A apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RAD9A cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
RAD9A GO:0000076,GO:0000077,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0006281,GO:0006974,GO:0008311,GO:0008408,GO:0008630,GO:0017124,GO:0019899,GO:0019901,GO:0030896,GO:0031573,GO:0042826,GO:0071479,GO:0071479,GO:1902231

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RAD9A hsa:5883 path:hsa04218 Cellular senescence - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ABL1 RAD9A 11971963 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 RAD9A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP53 RAD9A 18922183 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RAD9A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RAD9A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RAD9A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RAD9A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RAD9A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RAD9A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RAD9A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
YBX1 RAD9A 20596676 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000A07C1 RAD9A 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 RAD9A 22135298 phosphorylation N/A PhosphoSite
TLK1 RAD9A 22135298 phosphorylation N/A PhosphoSite
CDK1 RAD9A 22135298 phosphorylation N/A PhosphoSite
ABL1 RAD9A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
CDK2 RAD9A 22135298 phosphorylation N/A PhosphoSite
ATM RAD9A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RPA1 RAD9A 25361965 interaction type N/A PTMCode2
RAD9A RPA1 25361965 interaction type N/A PTMCode2
RAD9A ATM 25361965 interaction type N/A PTMCode2
BCL2L1 RAD9A 25361965 interaction type N/A PTMCode2
RAD9A BCL2L1 25361965 interaction type N/A PTMCode2
TOPBP1 RAD9A 25361965 interaction type N/A PTMCode2
RAD9A TOPBP1 25361965 interaction type N/A PTMCode2
RAD9A CLSPN 25361965 interaction type N/A PTMCode2
CLSPN RAD9A 25361965 interaction type N/A PTMCode2
RAD9A BCL2 25361965 interaction type N/A PTMCode2
BCL2 RAD9A 25361965 interaction type N/A PTMCode2
RAD9A RAD1 25361965 interaction type N/A PTMCode2
RAD1 RAD9A 25361965 interaction type N/A PTMCode2
RAD9A ABL1 25361965 interaction type N/A PTMCode2
RAD9A PCNA 25361965 interaction type N/A PTMCode2
PCNA RAD9A 25361965 interaction type N/A PTMCode2
RAD9A RAD17 25361965 interaction type N/A PTMCode2
RAD17 RAD9A 25361965 interaction type N/A PTMCode2
RAD9A HUS1B 25361965 interaction type N/A PTMCode2
HUS1B RAD9A 25361965 interaction type N/A PTMCode2
RAD9A CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 RAD9A 25361965 interaction type N/A PTMCode2
RAD9A RAD9B 25361965 interaction type N/A PTMCode2
RAD9B RAD9A 25361965 interaction type N/A PTMCode2
RAD9A DNAJC7 25361965 interaction type N/A PTMCode2
DNAJC7 RAD9A 25361965 interaction type N/A PTMCode2
HUS1 RAD9A 25361965 interaction type N/A PTMCode2
RAD9A HUS1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PCNA RAD9A 11994305 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MSH3 RAD9A 25348397 N/A physical interaction ComPPI
TP53BP1 RAD9A 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
BCL2L1 RAD9A 10620799 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
ATR RAD9A 25348397 N/A physical interaction ComPPI
AR RAD9A 14525934 14966297 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
COPS5 RAD9A 25348397 N/A physical interaction ComPPI
RPA1 RAD9A 14525934 15897895 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FEN1 RAD9A 25348397 N/A physical interaction ComPPI
HUS1 RAD9A 10359610 14525934 14624239 19464297 24234451 25348397 9872989 physical association anti bait coimmunoprecipitation,two hybrid,cosedimentation through density gradient,experimental interaction detection,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
RAD9A CHEK2 12049741 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RAD9A ATM 11278446 12709442 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RAD9A DNAJC7 25348397 N/A physical interaction,in vitro,in vivo ComPPI
RAD9A RAD17 10884395 12578958 14525934 20424596 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RAD9A CLSPN 12766152 14525934 20424596 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RAD9A HUS1B 11944979 14525934 14611806 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RAD9A ATAD5 14525934 15983387 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
RAD9A MLH1 14525934 18842633 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
RAD9A RPA2 14525934 15897895 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RAD9A BCL2 10620799 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
RAD9A NR3C1 25348397 N/A physical interaction ComPPI
RAD9A RAD1 10359610 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD9A HDAC1 10846170 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
RAD9A ABL1 11971963 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
RAD9A TOPBP1 11395493 14525934 17006541 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
RAD9A SETMAR 25348397 N/A physical interaction ComPPI
RAD9A DNMT1 25348397 N/A physical interaction ComPPI
RAD9A SF3B3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RAD9A FEM1B 25348397 N/A physical interaction ComPPI
RAD9A MSH2 25348397 N/A physical interaction ComPPI
RAD9A MSH6 25348397 N/A physical interaction ComPPI
RAD9A ATRX 25348397 N/A physical interaction ComPPI
RAD9A RHNO1 25348397 N/A physical interaction ComPPI
RAD9A TWNK 25348397 N/A physical interaction ComPPI
RAD9A TRIM25 25348397 N/A physical interaction ComPPI
RAD9A BRCA1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
ITSN2 RAD9A 12766152 14525934 N/A experimental interaction detection HPRD
RAD9B RAD9A 14500360 14525934 N/A experimental interaction detection HPRD
ATM RAD9A 11278446 12709442 18669648 22453082 27898060 stimulant N/A OmniPath
RAD17 RAD9A 10884395 11572977 12578958 14611806 18082599 20424596 27898060 stimulant N/A OmniPath
ABL1 RAD9A 11971963 20841568 27898060 inhibition,stimulant N/A OmniPath
CDK1 RAD9A 12709442 12734188 18940270 20021694 20305300 23028682 24098381 24376897 27898060 stimulant N/A OmniPath
TLK1 RAD9A 12709442 18940270 24376897 27898060 stimulant N/A OmniPath
TOPBP1 RAD9A 11395493 12941802 17006541 17575048 19652550 27898060 stimulant N/A OmniPath
RAD9A TOPBP1 11395493 12941802 17006541 17575048 18594563 27898060 stimulant N/A OmniPath
CSNK2A1 RAD9A 20724438 20858457 22925454 25091155 26088138 27898060 N/A N/A OmniPath

Visualization










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