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GENE：RANGAP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RANGAP1
FullNmae Ran GTPase activating protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9854
EnsembleID ENSG00000100401
Uniprot P46060

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RANGAP1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RANGAP1 cuproptosis 37243753 However, there are very few studies of cuproptosis in GC. In this paper, a prediction model related to cuproptosis was established and verified through data mining, and the six genes related to cuproptosis were ACLY, FGD6, SERPINE1, SPATA13, RANGAP1, and ADGRE5. genes related to cuproptosis

Go Annotation:

GeneSymbol Go id
RANGAP1 GO:0000776,GO:0003723,GO:0005096,GO:0005096,GO:0005515,GO:0005634,GO:0005635,GO:0005635,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0006913,GO:0007165,GO:0016235,GO:0016925,GO:0030425,GO:0031267,GO:0031267,GO:0031625,GO:0031965,GO:0043231,GO:0044614,GO:0045296,GO:0046826,GO:0048471,GO:0048471,GO:0048678,GO:0051168,GO:0072686,GO:0090630,GO:0090630,GO:0106068,GO:1904115,GO:1904117,GO:1990723

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RANGAP1 hsa:5905 path:hsa03013 Nucleocytoplasmic transport - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RANGAP1 SUMO1 18093978 23180781 physical association anti tag coimmunoprecipitation InnateDB
WAS RANGAP1 23180781 24872192 physical association anti tag coimmunoprecipitation InnateDB
RNF2 RANGAP1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR RANGAP1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 RANGAP1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 RANGAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RANGAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RANGAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RANGAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RANGAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 RANGAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 RANGAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 RANGAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000FC8EB RANGAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC RANGAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000001EB3 RANGAP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003ACE11 RANGAP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 RANGAP1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000018D2BE RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000035CC3E RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000005481D RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000016FD1A RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000021D7C8 RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS0000021D08 RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS0000508C13 RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000041E949 RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000027080C RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS0000346991 RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS0000070CD2 RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00000DDD35 RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS0000298BA3 RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00002B3783 RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS0000042E1F RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00002075FA RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00000600E6 RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000039E1E1 RANGAP1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00003AA845 RANGAP1 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 RANGAP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 RANGAP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 RANGAP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB RANGAP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002FB065 RANGAP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005C1F22 RANGAP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 RANGAP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 RANGAP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CC005 RANGAP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 RANGAP1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000101787 RANGAP1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000040FA88 RANGAP1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000003575B RANGAP1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000259AE4 RANGAP1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 RANGAP1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002EF20A RANGAP1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000010BD8D RANGAP1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D15B RANGAP1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000209F04 RANGAP1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041FA2C RANGAP1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 RANGAP1 22135298 phosphorylation N/A PhosphoSite
CDK1 RANGAP1 22135298 phosphorylation N/A PhosphoSite
SUMO1 RANGAP1 25361965 interaction type N/A PTMCode2
RANGAP1 SUMO1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GNAI3 RANGAP1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2I RANGAP1 11853669 14525934 15931224 16732283 17036045 17353931 19549727 21988832 23395904 24234451 25348397 26496610 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,in vitro,confocal microscopy ComPPI,HPRD,IntAct
SNW1 RANGAP1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L RANGAP1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SH3GLB1 RANGAP1 25348397 N/A physical interaction ComPPI
TPD52L2 RANGAP1 25348397 N/A physical interaction ComPPI
PPIB RANGAP1 25348397 N/A physical interaction ComPPI
TRAF6 RANGAP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
LMNA RANGAP1 25348397 N/A physical interaction ComPPI
GABARAPL2 RANGAP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FOXB1 RANGAP1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RAN RANGAP1 10394366 14525934 25348397 7744835 9219684 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
POLR3C RANGAP1 25348397 N/A physical interaction ComPPI
KEAP1 RANGAP1 25348397 N/A physical interaction ComPPI
PCGF2 RANGAP1 25348397 N/A physical interaction ComPPI
UBE2E3 RANGAP1 25348397 N/A physical interaction ComPPI
NLK RANGAP1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
JUN RANGAP1 24234451 25348397 25609649 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
SUMO1 RANGAP1 10961991 14525934 15576338 15931224 16428860 16732283 17000644 17036045 17099698 17099700 20414307 23395904 24234451 25348397 9019411 9442102 covalent binding,association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,molecular sieving,x-ray crystallography,covalent binding,physical interaction,enzymatic study,in vitro,in vivo,comigration in sds page ComPPI,HPRD,IntAct
U2AF2 RANGAP1 25348397 N/A physical interaction ComPPI
KPNB1 RANGAP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUP85 RANGAP1 25348397 N/A physical interaction ComPPI
DYNC1LI1 RANGAP1 25348397 N/A physical interaction ComPPI
DLD RANGAP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NTRK1 RANGAP1 25348397 N/A physical interaction ComPPI
CDH1 RANGAP1 25348397 N/A physical interaction ComPPI
BAG1 RANGAP1 25348397 N/A physical interaction ComPPI
NCOA6 RANGAP1 25348397 N/A physical interaction ComPPI
CCL5 RANGAP1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AXIN2 RANGAP1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SUB1 RANGAP1 25348397 N/A physical interaction ComPPI
CSNK2A1 RANGAP1 14525934 16428860 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DBNL RANGAP1 25348397 N/A physical interaction ComPPI
UBR5 RANGAP1 25348397 N/A physical interaction ComPPI
MYO18A RANGAP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDHA1 RANGAP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RCC1 RANGAP1 25348397 N/A physical interaction ComPPI
XPO1 RANGAP1 25348397 N/A physical interaction ComPPI
ATP6AP2 RANGAP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HUWE1 RANGAP1 25348397 N/A physical interaction ComPPI
TOPORS RANGAP1 25348397 N/A physical interaction ComPPI
IPO11 RANGAP1 25348397 N/A physical interaction ComPPI
SUMO2 RANGAP1 14525934 16620772 17099698 17099700 24234451 25348397 27898060 9556629 physical association experimental interaction detection,molecular sieving,enzymatic study,in vivo ComPPI,HPRD,IntAct,OmniPath
SAE1 RANGAP1 25348397 N/A physical interaction ComPPI
SUMO3 RANGAP1 14525934 16620772 17000644 24234451 25348397 association affinity chromatography technology,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
RANGAP1 RANBP2 11854305 12192048 14525934 25348397 9019411 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RANGAP1 IPO8 14525934 25348397 9214382 N/A experimental interaction detection,in vitro ComPPI,HPRD
RANGAP1 BABAM1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RANGAP1 MEPCE 25348397 N/A physical interaction ComPPI
RANGAP1 PMS1 25348397 N/A physical interaction ComPPI
RANGAP1 ARRB2 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RANGAP1 SIRT7 25348397 N/A physical interaction ComPPI
RANGAP1 USPL1 25348397 N/A physical interaction ComPPI
RANGAP1 NXF1 18596238 20123736 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RANGAP1 PRDX6 25348397 N/A physical interaction ComPPI
RANGAP1 NDUFA7 25348397 N/A physical interaction ComPPI
RANGAP1 SORD 25348397 N/A physical interaction ComPPI
RANGAP1 PRPF8 25348397 N/A physical interaction ComPPI
RANGAP1 EFTUD2 25348397 N/A physical interaction ComPPI
RANGAP1 PPIF 25348397 N/A physical interaction ComPPI
RANGAP1 PNPT1 25348397 N/A physical interaction ComPPI
RANGAP1 MMS19 25348397 N/A physical interaction ComPPI
RANGAP1 EGFR 25348397 N/A physical interaction ComPPI
RANGAP1 GNAI1 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
RANGAP1 SENP1 16553580 17099698 24234451 25027693 25348397 27898060 physical association isothermal titration calorimetry,x-ray crystallography,physical interaction,enzymatic study ComPPI,IntAct,OmniPath
RANGAP1 MIB1 25348397 N/A physical interaction ComPPI
RANGAP1 KIFBP 25348397 N/A physical interaction ComPPI
RANGAP1 ACTR2 25348397 N/A physical interaction ComPPI
RANGAP1 ACTR3 25348397 N/A physical interaction ComPPI
RANGAP1 ARPC1B 25348397 N/A physical interaction ComPPI
RANGAP1 ARPC2 25348397 N/A physical interaction ComPPI
RANGAP1 EEF2K 25348397 N/A physical interaction ComPPI
RANGAP1 EFL1 25348397 N/A physical interaction ComPPI
RANGAP1 LPP 25348397 N/A physical interaction ComPPI
RANGAP1 NIF3L1 25348397 N/A physical interaction ComPPI
RANGAP1 NSUN2 25348397 N/A physical interaction ComPPI
RANGAP1 OSGEP 25348397 N/A physical interaction ComPPI
RANGAP1 PANK4 25348397 N/A physical interaction ComPPI
RANGAP1 RPRD1B 25348397 N/A physical interaction ComPPI
RANGAP1 TPRKB 25348397 N/A physical interaction ComPPI
RANGAP1 UFM1 25348397 N/A physical interaction ComPPI
RANGAP1 SENP2 17099700 24234451 25348397 physical association molecular sieving,x-ray crystallography,physical interaction,enzymatic study ComPPI,IntAct
RANGAP1 CUL7 25348397 N/A physical interaction ComPPI
RANGAP1 OBSL1 25348397 N/A physical interaction ComPPI
RANGAP1 RNF2 25348397 N/A physical interaction ComPPI
RANGAP1 SMAP 25348397 N/A physical interaction ComPPI
RANGAP1 CERT1 25348397 N/A physical interaction ComPPI
RANGAP1 CPSF4 25348397 N/A physical interaction ComPPI
RANGAP1 EEF1G 25348397 N/A physical interaction ComPPI
RANGAP1 GNL1 25348397 N/A physical interaction ComPPI
RANGAP1 GTF3C3 25348397 N/A physical interaction ComPPI
RANGAP1 IPO5 25348397 N/A physical interaction ComPPI
RANGAP1 KDM2A 25348397 N/A physical interaction ComPPI
RANGAP1 NCL 25348397 N/A physical interaction ComPPI
RANGAP1 PCF11 25348397 N/A physical interaction ComPPI
RANGAP1 RALY 25348397 N/A physical interaction ComPPI
RANGAP1 PTBP1 25348397 N/A physical interaction ComPPI
RANGAP1 RGPD2 25348397 N/A physical interaction ComPPI
RANGAP1 RGPD5 25348397 N/A physical interaction ComPPI
RANGAP1 SUPT5H 25348397 N/A physical interaction ComPPI
RANGAP1 UBR4 25348397 N/A physical interaction ComPPI
RANGAP1 NUP107 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RANGAP1 NUP35 25348397 N/A physical interaction ComPPI
RANGAP1 NUP153 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RANGAP1 SEH1L 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RANGAP1 RBPJ 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RANGAP1 FOXE1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RANGAP1 FOXJ3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RANGAP1 TMUB1 25348397 N/A physical interaction ComPPI
RANGAP1 FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RANGAP1 FOXQ1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RANGAP1 CTDSPL2 25348397 N/A physical interaction ComPPI
RANGAP1 B2M 25348397 N/A physical interaction ComPPI
RANGAP1 NEMP1 25348397 N/A physical interaction ComPPI
RANGAP1 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RANGAP1 TRIM25 25348397 N/A physical interaction ComPPI
RANGAP1 BRCA1 25348397 N/A physical interaction ComPPI
RANGAP1 CLEC14A 25348397 N/A physical interaction ComPPI
RANGAP1 URM1 21209336 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RANGAP1 MED19 15175163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RANGAP1 TMBIM4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RANGAP1 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RANGAP1 PRKAB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RANGAP1 SLX4 19596235 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RANGAP1 DLC1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RANGAP1 PDGFRL 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RANGAP1 STK4 23386615 24234451 25348397 association tandem affinity purification ComPPI,IntAct
RANGAP1 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
RANGAP1 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
RANGAP1 NBEAL2 24234451 25348397 29187380 association tandem affinity purification ComPPI,IntAct
SOX2 RANGAP1 25348397 N/A physical interaction ComPPI
TP53RK RANGAP1 25348397 N/A physical interaction ComPPI
PPP2R5D RANGAP1 25348397 N/A physical interaction ComPPI
CPSF1 RANGAP1 25348397 N/A physical interaction ComPPI
THG1L RANGAP1 25348397 N/A physical interaction ComPPI
CALU RANGAP1 25348397 N/A physical interaction ComPPI
RANGAP1 RANGAP1 14525934 8146159 N/A experimental interaction detection HPRD
RANGAP1 NEUROD6 24234451 30021884 physical association cross-linking study IntAct
RANGAP1 KAT6A 24234451 30021884 physical association cross-linking study IntAct
RANGAP1 PPP2R5A 24234451 30021884 physical association cross-linking study IntAct
RANGAP1 WT1-AS 18591351 27898060 N/A N/A OmniPath
MAP3K8 RANGAP1 15037602 27898060 N/A N/A OmniPath
CDK2 RANGAP1 15037602 27898060 N/A N/A OmniPath
CDK1 RANGAP1 15037602 27898060 stimulant N/A OmniPath
UBE2I RANGAP1 11792325 11853669 12821332 12924945 14578449 15094046 15931224 16194093 16732283 16820290 17036045 17353931 18538659 18691969 18706886 19549727 20501649 20719936 21098080 21139563 21988832 22194619 23395904 24753249 26496610 27898060 9497385 stimulant N/A OmniPath
CSNK2A1 RANGAP1 16428860 18669648 27898060 stimulant N/A OmniPath
RANBP2 RANGAP1 11709548 11854305 12192048 15388847 15931224 16524884 19526197 21518904 22194619 22464730 26344197 27898060 9019411 stimulant N/A OmniPath
WAS RANGAP1 24872192 27898060 N/A N/A OmniPath

Visualization










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