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GENE：TONSL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TONSL
FullNmae tonsoku like, DNA repair protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7801
EnsembleID ENSG00000160949
Uniprot Q96HA7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TONSL necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TONSL GO:0000724,GO:0000724,GO:0000724,GO:0005515,GO:0005654,GO:0005737,GO:0006325,GO:0016604,GO:0031297,GO:0031297,GO:0031297,GO:0035861,GO:0042393,GO:0043596,GO:0043596,GO:0071168,GO:0140566

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 TONSL 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TONSL 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TONSL 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TONSL 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TONSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TONSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TONSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TONSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TONSL 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003D5391 TONSL 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD TONSL 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003E2232 TONSL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031B6ED TONSL 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MCM5 TONSL 25348397 N/A physical interaction ComPPI
MCM6 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MCM2 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
H4C1 TONSL 25348397 N/A physical interaction ComPPI
ASF1A TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
GSK3B TONSL 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NTRK1 TONSL 25348397 N/A physical interaction ComPPI
XRCC5 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MYC TONSL 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
XRCC6 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
EWSR1 TONSL 25348397 N/A physical interaction ComPPI
H3-4 TONSL 25348397 N/A physical interaction ComPPI
H1-5 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SUPT16H TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
H3C1 TONSL 24234451 25348397 29568061 association pull down,physical interaction ComPPI,IntAct
ASF1B TONSL 17353931 21113133 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
SSRP1 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
H2AX TONSL 25348397 N/A physical interaction ComPPI
MCM3 TONSL 25348397 N/A physical interaction ComPPI
MCM4 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
BRCA1 TONSL 24234451 25348397 29656893 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
H2AC4 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
H1-2 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MCM7 TONSL 25348397 N/A physical interaction ComPPI
SUGT1 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SLC25A5 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
AIFM1 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SLC25A3 TONSL 21113133 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TONSL H2BC1 25348397 N/A physical interaction ComPPI
TONSL MACROH2A2 25348397 N/A physical interaction ComPPI

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