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GENE：SAMM50

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SAMM50
FullNmae SAMM50 sorting and assembly machinery component
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24276
EnsembleID ENSG00000100347
Uniprot Q9Y512

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SAMM50 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
SAMM50 GO:0001401,GO:0001401,GO:0001401,GO:0005515,GO:0005739,GO:0005739,GO:0005741,GO:0005741,GO:0007007,GO:0016020,GO:0033108,GO:0033108,GO:0042407,GO:0045040,GO:0045040,GO:0045040,GO:0070062,GO:0140275

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SAMM50 hsa:25813 path:hsa04137 Mitophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SUZ12 SAMM50 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 SAMM50 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SAMM50 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SAMM50 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SAMM50 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SAMM50 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SAMM50 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SAMM50 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SAMM50 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SAMM50 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CHCHD3 SAMM50 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HSPA8 SAMM50 25348397 N/A physical interaction ComPPI
NPM1 SAMM50 25348397 N/A physical interaction ComPPI
TOMM22 SAMM50 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MEOX2 SAMM50 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TIMMDC1 SAMM50 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDUFAF4 SAMM50 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SAMM50 MICOS10 25348397 N/A physical interaction ComPPI
SAMM50 NDUFS8 25348397 N/A physical interaction ComPPI
SAMM50 MRPL11 25348397 N/A physical interaction ComPPI
SAMM50 NDUFS3 25348397 N/A physical interaction ComPPI
SAMM50 SSBP1 25348397 N/A physical interaction ComPPI
SAMM50 SDHA 25348397 N/A physical interaction ComPPI
SAMM50 MRPS11 25348397 N/A physical interaction ComPPI
SAMM50 CYC1 25348397 N/A physical interaction ComPPI
SAMM50 SURF1 25348397 N/A physical interaction ComPPI
SAMM50 RPS23 25348397 N/A physical interaction ComPPI
SAMM50 NDUFB8 25348397 N/A physical interaction ComPPI
SAMM50 TOMM40 15644312 18358813 21680715 22939629 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SAMM50 HNRNPM 25348397 N/A physical interaction ComPPI
SAMM50 SQOR 25348397 N/A physical interaction ComPPI
SAMM50 SERINC1 25348397 N/A physical interaction ComPPI
SAMM50 HNRNPUL1 25348397 N/A physical interaction ComPPI
SAMM50 RHOT2 25348397 N/A physical interaction ComPPI
SAMM50 SLC25A17 25348397 N/A physical interaction ComPPI
SAMM50 CLN3 25348397 N/A physical interaction ComPPI
SAMM50 SUZ12 25348397 N/A physical interaction ComPPI
SAMM50 EGFR 25348397 N/A physical interaction ComPPI
SAMM50 MTX2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SAMM50 MICOS13 25348397 N/A physical interaction ComPPI
SAMM50 APOOL 25348397 N/A physical interaction ComPPI
SAMM50 NMES1 25348397 N/A physical interaction ComPPI
SAMM50 NDUFA4 25348397 N/A physical interaction ComPPI
SAMM50 DUSP22 25348397 N/A physical interaction ComPPI
SAMM50 MTM1 25348397 N/A physical interaction ComPPI
SAMM50 RAB8A 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
SAMM50 HNRNPL 25348397 N/A physical interaction ComPPI
SAMM50 MTX1 17510655 24234451 25348397 colocalization blue native page ComPPI,IntAct
SAMM50 IMMT 17624330 22009199 22496419 22575891 22918945 24234451 25348397 27898060 association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
SAMM50 MFN2 24234451 25348397 27059175 physical association anti tag coimmunoprecipitation ComPPI,IntAct
SAMM50 DNM1L 24234451 25348397 27059175 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
SAMM50 CHCHD6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SAMM50 AIFM1 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
SAMM50 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SAMM50 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SAMM50 SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SAMM50 PRELID3B 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SAMM50 ATP5F1A 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SAMM50 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
COX4I1 SAMM50 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PLGRKT SAMM50 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct

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