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GENE：SARS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SARS2
FullNmae seryl-tRNA synthetase 2, mitochondrial
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17697
EnsembleID ENSG00000104835
Uniprot Q9NP81

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SARS2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SARS2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
SARS2 GO:0000049,GO:0003723,GO:0004828,GO:0004828,GO:0005515,GO:0005524,GO:0005739,GO:0005739,GO:0005759,GO:0006434,GO:0070158

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SARS2 hsa:54938 path:hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SARS2 RBX1 18203720 23180781 physical association anti tag coimmunoprecipitation InnateDB
SARS2 SKP1 18203720 23180781 physical association anti tag coimmunoprecipitation InnateDB
SARS2 CUL1 18203720 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 SARS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC SARS2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 SARS2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D SARS2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
CUL5 SARS2 25348397 N/A physical interaction ComPPI
CHCHD2 SARS2 25348397 N/A physical interaction ComPPI
SKP1 SARS2 25348397 N/A physical interaction ComPPI
FBXO17 SARS2 25348397 N/A physical interaction ComPPI
RAD21 SARS2 25348397 N/A physical interaction ComPPI
HSP90AB1 SARS2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
TUFM SARS2 25348397 N/A physical interaction ComPPI
RACK1 SARS2 25348397 N/A physical interaction ComPPI
CAVIN3 SARS2 25348397 N/A physical interaction ComPPI
NF2 SARS2 25348397 N/A physical interaction ComPPI
NFATC1 SARS2 25348397 N/A physical interaction ComPPI
CASP3 SARS2 11331419 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
JUN SARS2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 SARS2 25348397 N/A physical interaction ComPPI
RBX1 SARS2 25348397 N/A physical interaction ComPPI
CUL3 SARS2 25348397 N/A physical interaction ComPPI
HSP90AA1 SARS2 25348397 N/A physical interaction ComPPI
NTRK1 SARS2 25348397 N/A physical interaction ComPPI
IRF3 SARS2 25348397 N/A physical interaction ComPPI
EEF1A1 SARS2 14525934 15109557 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SPTAN1 SARS2 25348397 N/A physical interaction ComPPI
PPP2CA SARS2 25348397 N/A physical interaction ComPPI
SQSTM1 SARS2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
UBE2B SARS2 25348397 N/A physical interaction ComPPI
COPS2 SARS2 25348397 N/A physical interaction ComPPI
CUL1 SARS2 25348397 N/A physical interaction ComPPI
UBE2A SARS2 25348397 N/A physical interaction ComPPI
COPS3 SARS2 25348397 N/A physical interaction ComPPI
COPS4 SARS2 25348397 N/A physical interaction ComPPI
COPS6 SARS2 25348397 N/A physical interaction ComPPI
PDK1 SARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SARS2 PUF60 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SARS2 USP44 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SARS2 DMWD 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SARS2 MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SARS2 MTHFD1 25348397 N/A physical interaction ComPPI
SARS2 ILF3 25348397 N/A physical interaction ComPPI
SARS2 NENF 25348397 N/A physical interaction ComPPI
SARS2 MATR3 25348397 N/A physical interaction ComPPI
SARS2 CDH2 25348397 N/A physical interaction ComPPI
SARS2 PPT2 25348397 N/A physical interaction ComPPI
SARS2 HSP90AA2P 25348397 N/A physical interaction ComPPI
SARS2 ESR1 25348397 N/A physical interaction ComPPI
SARS2 HSPD1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SARS2 NMT1 25348397 N/A physical interaction ComPPI
SARS2 NMT2 25348397 N/A physical interaction ComPPI
SARS2 NDUFA2 25348397 N/A physical interaction ComPPI
SARS2 COPS7B 25348397 N/A physical interaction ComPPI
SARS2 CLPP 25348397 N/A physical interaction ComPPI
SARS2 FBXW2 25348397 N/A physical interaction ComPPI
SARS2 NDUFS6 25348397 N/A physical interaction ComPPI
SARS2 KCMF1 25348397 N/A physical interaction ComPPI
SARS2 HARS2 25348397 N/A physical interaction ComPPI
SARS2 TARS1 25348397 N/A physical interaction ComPPI
SARS2 SBDS 25348397 N/A physical interaction ComPPI
SARS2 CISD3 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SARS2 SPATA20 25348397 N/A physical interaction ComPPI
SARS2 PPTC7 25348397 N/A physical interaction ComPPI
SARS2 BPNT1 25348397 N/A physical interaction ComPPI
SARS2 TRMT10C 18984158 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
SARS2 TP53 22653443 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SARS2 SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
SARS2 NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SARS2 SPRYD4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SARS2 PRELID1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SARS2 COQ10A 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
ILF2 SARS2 25348397 N/A physical interaction ComPPI
MGST3 SARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CALU SARS2 25348397 N/A physical interaction ComPPI
TRMT61B SARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HSCB SARS2 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct

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